Trans-sulfuration pathway (WP2333)

Homo sapiens

Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.


Liang Zhao and Martina Summer-Kutmon


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Homo sapiens



Pathway Ontology

glutathione metabolic pathway


Label Type Compact URI Comment
Tetrahydrofolate (THF) Metabolite kegg.compound:C00101
L-Methionine Metabolite kegg.compound:C00073
5-Methyl-THF Metabolite kegg.compound:C00440
L-Homocysteine Metabolite kegg.compound:C00155
S-Adenosylmethionine (SAMe) Metabolite kegg.compound:C00019
S-Adenosylhomocysteine (SAH) Metabolite kegg.compound:C00021
L-Cysteine Metabolite kegg.compound:C00097
Glutathione Metabolite kegg.compound:C00051
Taurine Metabolite kegg.compound:C00245
L-Glutamate Metabolite kegg.compound:C00025
Pyruvate Metabolite kegg.compound:C00022
ATP Metabolite kegg.compound:C00002
ADP Metabolite kegg.compound:C00008
Phosphate Metabolite kegg.compound:C00009
MTR GeneProduct ncbigene:4548
MAT2B GeneProduct ncbigene:27430
DNMT1 GeneProduct ncbigene:1786
AHCY GeneProduct ncbigene:191
CBS GeneProduct ncbigene:875
CTH GeneProduct ncbigene:1491
CTH GeneProduct ncbigene:1491
GOT1 GeneProduct ncbigene:2805
MPST GeneProduct ncbigene:4357
GCLM GeneProduct ncbigene:2730
CSAD GeneProduct ncbigene:51380
GCLM GeneProduct ncbigene:2730


  1. Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity. Beger RD, Sun J, Schnackenberg LK. Toxicol Appl Pharmacol. 2010 Mar 1;243(2):154–66. PubMed Europe PMC Scholia