RalA downstream regulated genes (WP2290)

Homo sapiens

Downstream genes of RalA signaling pathways, including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell division cycle 42), RAC1 (ras-related C3 botulinum toxin substrate 1), RAC2, RAC3, the Y-box transcription factor ZO-1-associated nucleic acidbinding protein (ZONAB, also known as cold shock domain protein A (CSDA)), and two subunits of the exocyst complex, SEC5 (also known as exocyst complex component 2 (EXOC2)) and EXO84 (also known as EXOC8), which are involved in regulating cell proliferation, apoptosis and migration


Martina Summer-Kutmon , Daniela Digles , and Zahra Roudbari


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

Ras family mediated signaling pathway

Disease Ontology

chronic myeloid leukemia


Label Type Compact URI Comment
ZONAB GeneProduct ncbigene:8531
SEC5 GeneProduct ncbigene:55770
EXOC84 GeneProduct ncbigene:149371
RALBP1 GeneProduct ncbigene:10928
CDC42 GeneProduct ncbigene:998
RAC3 GeneProduct ncbigene:5881
RAC2 GeneProduct ncbigene:5880
RAC1 GeneProduct ncbigene:5879
HRAS GeneProduct ncbigene:3265
KRAS GeneProduct ncbigene:3845
NRAS GeneProduct ncbigene:4893
RalA GeneProduct ncbigene:5898


  1. miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML). Fei J, Li Y, Zhu X, Luo X. PLoS One. 2012;7(3):e32834. PubMed Europe PMC Scholia