RalA downstream regulated genes (WP2290)
Homo sapiens
Downstream genes of RalA signaling pathways, including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell division cycle 42), RAC1 (ras-related C3 botulinum toxin substrate 1), RAC2, RAC3, the Y-box transcription factor ZO-1-associated nucleic acidbinding protein (ZONAB, also known as cold shock domain protein A (CSDA)), and two subunits of the exocyst complex, SEC5 (also known as exocyst complex component 2 (EXOC2)) and EXO84 (also known as EXOC8), which are involved in regulating cell proliferation, apoptosis and migration
Authors
Martina Summer-Kutmon , Daniela Digles , and Zahra RoudbariActivity
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Cited In
- Identification of high‐dimensional omics‐derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling (2021).
- Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
Ras family mediated signaling pathwayDisease Ontology
chronic myeloid leukemia| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ZONAB | GeneProduct | ncbigene:8531 | |
| SEC5 | GeneProduct | ncbigene:55770 | |
| EXOC84 | GeneProduct | ncbigene:149371 | |
| RALBP1 | GeneProduct | ncbigene:10928 | |
| CDC42 | GeneProduct | ncbigene:998 | |
| RAC3 | GeneProduct | ncbigene:5881 | |
| RAC2 | GeneProduct | ncbigene:5880 | |
| RAC1 | GeneProduct | ncbigene:5879 | |
| HRAS | GeneProduct | ncbigene:3265 | |
| KRAS | GeneProduct | ncbigene:3845 | |
| NRAS | GeneProduct | ncbigene:4893 | |
| RalA | GeneProduct | ncbigene:5898 |
References
- miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML). Fei J, Li Y, Zhu X, Luo X. PLoS One. 2012;7(3):e32834. PubMed Europe PMC Scholia