Macrophage markers (WP2271)

Mus musculus

Overview of macrophage markers. Based on [ this list] and tissue-specific gene expression from [ GeneAtlas].


Thomas Kelder


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Mus musculus



Cell Type Ontology



Label Type Compact URI Comment
Cd14 GeneProduct ncbigene:12475
Cd83 GeneProduct ncbigene:12522
Cd68 GeneProduct ncbigene:12514
F3 GeneProduct ncbigene:14066
Cd163 GeneProduct ncbigene:93671
Cd86 GeneProduct ncbigene:12524
Cd74 GeneProduct ncbigene:16149
Cd52 GeneProduct ncbigene:23833
Rac2 GeneProduct ncbigene:19354
Lyz2 GeneProduct ncbigene:17105


  1. CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide. Mahnke K, Becher E, Ricciardi-Castagnoli P, Luger TA, Schwarz T, Grabbe S. Adv Exp Med Biol. 1997;417:145–59. PubMed Europe PMC Scholia
  2. Synergistic effects of colony-stimulating factor 1 and leukemia inhibitory factor in inducing early myeloid cell differentiation. Aperlo C, Sevilla L, Guerin S, Pognonec P, Boulukos KE. Cell Growth Differ. 1998 Nov;9(11):929–37. PubMed Europe PMC Scholia
  3. Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments. Fonseca JE, Edwards JCW, Blades S, Goulding NJ. Arthritis Rheum. 2002 May;46(5):1210–6. PubMed Europe PMC Scholia
  4. The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b. Brettschneider J, Ecker D, Bitsch A, Bahner D, Bogumil T, Dressel A, et al. J Neuroimmunol. 2002 Dec;133(1–2):193–7. PubMed Europe PMC Scholia
  5. CD163: a specific marker of macrophages in paraffin-embedded tissue samples. Lau SK, Chu PG, Weiss LM. Am J Clin Pathol. 2004 Nov;122(5):794–801. PubMed Europe PMC Scholia
  6. Expression of CD163 in the liver of patients with viral hepatitis. Hiraoka A, Horiike N, Akbar SMF, Michitaka K, Matsuyama T, Onji M. Pathol Res Pract. 2005;201(5):379–84. PubMed Europe PMC Scholia
  7. Identification of factor XIII-A as a marker of alternative macrophage activation. Töröcsik D, Bárdos H, Nagy L, Adány R. Cell Mol Life Sci. 2005 Sep;62(18):2132–9. PubMed Europe PMC Scholia
  8. The “classical” macrophage marker CD68 is strongly expressed in primary human fibroblasts. Kunz-Schughart LA, Weber A, Rehli M, Gottfried E, Brockhoff G, Krause SW, et al. Verh Dtsch Ges Pathol. 2003;87:215–23. PubMed Europe PMC Scholia