Synaptic vesicle pathway (WP2267)

Homo sapiens

Pathway depicting synaptic transmission of neurotransmitters from the presynaptic nerve terminal to the synaptic cleft upon depolarization. Synaptotagmin mediated transport along the nerve cell cytoskeleton indicates the initial step of this process. Originally created by Joanna S. Fong and Nathan Salomonis in the Bruce Conklin laboratory 5/12/2000 for use in GenMAPP. Genes associated with neurotransmitter reuptake from the synaptic left were obtained from the Gene Ontology term GO:0001504. For additional information see: Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal].


Nathan Salomonis , Egon Willighagen , Friederike Ehrhart , Kristina Hanspers , and Eric Weitz


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Homo sapiens



Pathway Ontology

synaptic vesicle cycle pathway

Cell Type Ontology



Label Type Compact URI Comment
L-Glutamine Metabolite hmdb:HMDB0000641
Dopamine Metabolite hmdb:HMDB0000073
ATP Metabolite chebi:15422
Ca2+ Metabolite chebi:29108
ADP Metabolite chebi:16761
Ca2+ Metabolite chebi:29108
Serotonin Metabolite hmdb:HMDB0000259
Glutamate Metabolite chebi:29987
SYN1 GeneProduct ensembl:ENSG00000008056
RAB3A GeneProduct ensembl:ENSG00000105649
SYN2 GeneProduct ensembl:ENSG00000157152
SYN3 GeneProduct ensembl:ENSG00000185666
SYT1 GeneProduct ensembl:ENSG00000067715
VAMP2 GeneProduct ensembl:ENSG00000220205
STX1B GeneProduct ensembl:ENSG00000099365
STX2 GeneProduct ensembl:ENSG00000111450
STX1A GeneProduct ensembl:ENSG00000106089
STX3 GeneProduct ensembl:ENSG00000166900
SNAP25 GeneProduct ensembl:ENSG00000132639
RIMS1 GeneProduct ensembl:ENSG00000079841
STXBP1 GeneProduct ensembl:ENSG00000136854
RAB3A GeneProduct ensembl:ENSG00000105649
UNC13C GeneProduct ensembl:ENSG00000137766
UNC13B GeneProduct ensembl:ENSG00000198722
UNC13A GeneProduct ensembl:ENSG00000130477
CPLX3 GeneProduct ensembl:ENSG00000213578
CPLX2 GeneProduct ensembl:ENSG00000145920
CPLX1 GeneProduct ensembl:ENSG00000168993
NAPA GeneProduct ensembl:ENSG00000105402
NSF GeneProduct ensembl:ENSG00000073969
CACNA1A GeneProduct ensembl:ENSG00000141837
CACNA1B GeneProduct ensembl:ENSG00000148408
RAB3A GeneProduct ensembl:ENSG00000105649
SYP GeneProduct ensembl:ENSG00000102003
DNM1 GeneProduct ensembl:ENSG00000106976
DNM1L GeneProduct ensembl:ENSG00000087470
DNM2 GeneProduct ensembl:ENSG00000079805
DNM3 GeneProduct ensembl:ENSG00000197959
CLTA GeneProduct ensembl:ENSG00000122705
CLTC GeneProduct ensembl:ENSG00000141367
CLTCL1 GeneProduct ensembl:ENSG00000070371
AP2S1 GeneProduct ensembl:ENSG00000042753
AP2A1 GeneProduct ensembl:ENSG00000196961
AP2A2 GeneProduct ensembl:ENSG00000183020
AP2B1 GeneProduct ensembl:ENSG00000006125
AP2M1 GeneProduct ensembl:ENSG00000161203
SLC32A1 GeneProduct ensembl:ENSG00000101438
SLC17A8 GeneProduct ensembl:ENSG00000179520
SLC17A7 GeneProduct ensembl:ENSG00000104888
SLC17A6 GeneProduct ensembl:ENSG00000091664
SLC18A1 GeneProduct ensembl:ENSG00000036565
SLC18A2 GeneProduct ensembl:ENSG00000165646
SLC18A3 GeneProduct ensembl:ENSG00000187714
SLC32A1 GeneProduct ensembl:ENSG00000101438
SLC22A3 GeneProduct ensembl:ENSG00000146477
SLC38A1 GeneProduct ensembl:ENSG00000111371
PARK7 GeneProduct ensembl:ENSG00000116288
SLC1A3 GeneProduct ensembl:ENSG00000079215
CLN8 GeneProduct ensembl:ENSG00000182372
SLC6A4 GeneProduct ensembl:ENSG00000108576
SLC25A4 GeneProduct ensembl:ENSG00000151729
ATP1A2 GeneProduct ensembl:ENSG00000018625