Cell engulfment (WP2226)

Caenorhabditis elegans

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A model of apoptotic cell engulfment. Caenorhabditis (from Caeno and rhabditis = rod like stick shaped) elegans is a free living (non parasitic) transparent roundworm (nematode). C. elegans was the first organism to have its whole genome sequenced and it neuronal wiring described. The C. elegans engulfment pathway removes the dying ("corpse") cells by using receptor signals then identifying the dying cells and eventually engulfing them. The final process involves the recycling of the remaining cell particles of the dead engulfed cells.

Authors

Karen Yook , Christine Chichester , Kristina Hanspers , Christian Grove , Egon Willighagen , Martina Summer-Kutmon , Asios Olia , and Friederike Ehrhart

Activity

last edited

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Organisms

Caenorhabditis elegans

Communities

WormBase

Annotations

Pathway Ontology

apoptotic cell death pathway phagocytosis pathway

Participants

Label Type Compact URI Comment
CED-4 GeneProduct ensembl:WBGene00000418
CED-9 GeneProduct ensembl:WBGene00000423
CED-10/Rac1 GeneProduct wormbase:C09G12.8
CED-5/DOCK180 GeneProduct ensembl:WBGene00000419
EGL-1 GeneProduct ensembl:WBGene00001170
CED-6 GeneProduct ensembl:WBGene00000420
CED-1/SREC? GeneProduct ensembl:WBGene00000415
CED-2/CrkII GeneProduct wormbase:Y41D4B.13
Active CED-3Protease GeneProduct ensembl:WBGene00000417
CED-3 GeneProduct ensembl:WBGene00000417
CED-7 GeneProduct ensembl:WBGene00000421
CED-7/ABC1 GeneProduct ensembl:WBGene00000421
PSR-1? GeneProduct ensembl:WBGene00004205

References

  1. How the worm removes corpses: the nematode C. elegans as a model system to study engulfment. Gumienny TL, Hengartner MO. Cell Death Differ. 2001 Jun;8(6):564–8. PubMed Europe PMC Scholia
  2. Programmed cell death. Conradt B, Xue D. WormBook. 2005 Oct 6;1–13. PubMed Europe PMC Scholia