Serotonin and anxiety-related events (WP2140)

Mus musculus

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Stress and anxiety disorders are risk factors for depression and these behaviours are modulated by corticotropin releasing factor (CRFR1) and serotonin (5-HT2R) receptors. (Source: Berg et al "5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms")

Authors

Yves Slenter , Linda Rieswijk , Martina Summer-Kutmon , Kristina Hanspers , and Egon Willighagen

Activity

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

disease pathway signaling pathway

Cell Type Ontology

neuron cerebral cortex neuron

Disease Ontology

anxiety disorder

Participants

Label Type Compact URI Comment
Serotonin Metabolite hmdb:HMDB0000259
ketanserin Metabolite chebi:6123
Serotonin Receptor Htr2a GeneProduct ensembl:ENSMUSG00000034997
Arc GeneProduct ensembl:ENSMUSG00000022602
Serotonin Receptor Htr2c GeneProduct ensembl:ENSMUSG00000041380
Serotonin Receptor Htr1a GeneProduct ensembl:ENSMUSG00000021721
C-Fos GeneProduct ensembl:ENSMUSG00000021250
Plek GeneProduct ensembl:ENSMUSG00000020120
Ppp3ca GeneProduct mgi:MGI:107164
Prkcb1 GeneProduct ensembl:ENSMUSG00000052889
Plcd4 GeneProduct ensembl:ENSMUSG00000026173
Grin2d GeneProduct ensembl:ENSMUSG00000002771
Nlgn1 GeneProduct ensembl:ENSMUSG00000063887
Crhr1 GeneProduct ensembl:ENSMUSG00000018634
CRF_MOUSE Protein uniprot:Q8CIT0

References

  1. 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Berg KA, Clarke WP, Chen Y, Ebersole BJ, McKay RD, Maayani S. Mol Pharmacol. 1994 May;45(5):826–36. PubMed Europe PMC Scholia
  2. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, et al. Nat Neurosci. 2010 May;13(5):622–9. PubMed Europe PMC Scholia
  3. Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability. Benekareddy M, Goodfellow NM, Lambe EK, Vaidya VA. J Neurosci. 2010 Sep 8;30(36):12138–50. PubMed Europe PMC Scholia