Serotonin and anxiety (WP2132)

Rattus norvegicus


Helix , Andra Waagmeester , Egon Willighagen , and Linda Rieswijk


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Rattus norvegicus



Pathway Ontology

disease pathway


Label Type Compact URI Comment
THDOC Metabolite pubchem.compound:91475
ketanserin Metabolite chebi:6123
Adra1a GeneProduct ensembl:ENSRNOG00000009522
Grin2d GeneProduct ensembl:ENSRNOG00000021063
Htr2a GeneProduct ensembl:ENSRNOG00000010063
Arc GeneProduct ensembl:ENSRNOG00000043465
Nlgn1 GeneProduct ensembl:ENSRNOG00000032576
Plek GeneProduct ensembl:ENSRNOG00000005214
Ppp3ca GeneProduct ensembl:ENSRNOG00000009882
Plcd4 GeneProduct ensembl:ENSRNOG00000016361
Htr1a GeneProduct ensembl:ENSRNOG00000010254
Htr2c GeneProduct ensembl:ENSRNOG00000030877
KPCB GeneProduct ensembl:ENSRNOG00000012061
Fos GeneProduct ensembl:ENSRNOG00000008015
CRF Protein uniprot:P01143


  1. Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress. Benekareddy M, Vadodaria KC, Nair AR, Vaidya VA. Biol Psychiatry. 2011 Dec 1;70(11):1024–32. PubMed Europe PMC Scholia