BMP signaling pathway (WP211)

Danio rerio

The bone morphogenetic protein (BMP) signalling pathway play critical roles in germ layer induction and patterning in early zebrafish embryos. Smad2/3 and Smad1/5/8 are intracellular effectors of BMPs. These Smads regulate, in cooperation with other factors, transcription of hundreds of target genes in the nucleus. The activity and stability of Smads are regulated by phosphorylation modifications.


Gabby Krens , Kristina Hanspers , Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , Denise Slenter , Egon Willighagen , Lauren J. Dupuis , and Laurent Winckers


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Danio rerio



Pathway Ontology

Bone morphogenetic proteins signaling pathway


Label Type Compact URI Comment
bmp1b GeneProduct ncbigene:559877
msx a GeneProduct ncbigene:30528
vent GeneProduct ncbigene:64810
bmp6 GeneProduct ensembl:ENSDARG00000015686
tbx2a GeneProduct ncbigene:30247
bmp5l GeneProduct ncbigene:337711
bmp1l GeneProduct ncbigene:30204
bmpr1a GeneProduct ncbigene:58145
bambi GeneProduct ncbigene:431736
hrb GeneProduct ensembl:ENSDART00000043960
smad1 GeneProduct ncbigene:30628
snai2 GeneProduct ensembl:ENSDART00000033566
acvr2b GeneProduct ensembl:ENSDARG00000044422
bmper GeneProduct ensembl:ENSDARG00000040893
bmp5 GeneProduct ncbigene:394026
tbx2b GeneProduct ncbigene:30253
bmp5 GeneProduct ncbigene:394026
follistatin GeneProduct ncbigene:30235
bmp1a GeneProduct ensembl:ENSDARG00000069054
gata5 GeneProduct ncbigene:30482
twsg1a GeneProduct ensembl:ENSDART00000049963
snai1a GeneProduct ensembl:ENSDARG00000056995
smad6a GeneProduct ensembl:ENSDARG00000053209
id3 GeneProduct ncbigene:246093
bmpr1bb GeneProduct ensembl:ENSDARG00000075729
bmp2b/swirl(swr) GeneProduct uniprot:O93369
msx c GeneProduct ncbigene:30526
smurf-1(WWP1) GeneProduct ensembl:ENSDART00000004923
bmp2b GeneProduct uniprot:O93369
rack1 (gnb2l1) GeneProduct ncbigene:30722
smad1 GeneProduct ncbigene:30628
smad6 GeneProduct ensembl:ENSDARG00000031763
bmp4 GeneProduct ncbigene:30612
gata6 GeneProduct ncbigene:58076
deltaNP63/tp73l GeneProduct ncbigene:325581
crim1 GeneProduct ncbigene:404210
deltaNP63/tp73l GeneProduct ncbigene:335185
rpl15 GeneProduct ensembl:ENSDARG00000009285
smad8 GeneProduct ensembl:ENSDART00000028618
bmp15 GeneProduct ensembl:ENSDARG00000037491
deltaNP63/tp73l GeneProduct ncbigene:325581
bmp3 GeneProduct ncbigene:335252
bmp1b/tolloid GeneProduct ncbigene:335826
gata2 GeneProduct ncbigene:30480
smad4 GeneProduct ensembl:ENSDARG00000045094
gata3 GeneProduct ncbigene:30458
follistatin-like 1 GeneProduct ensembl:ENSDARG00000015559
smad7 GeneProduct ensembl:ENSDARG00000016858
bmp1b/tolloid GeneProduct ncbigene:559877
bmp1a/tolloid GeneProduct wikidata:Q29772966
prdc GeneProduct ncbigene:378455
bambi GeneProduct ncbigene:83496
smurf2 GeneProduct ensembl:ENSDARG00000038067
msx d GeneProduct ncbigene:30531
acvr1/lost a fin (laf) GeneProduct ncbigene:30615
acvr2b GeneProduct ensembl:ENSDARG00000044422
gata4 GeneProduct ncbigene:30483
pcca GeneProduct ncbigene:437019
Nucleoporin like protein RAB GeneProduct ncbigene:393560
follistatin GeneProduct ncbigene:557352
bambi GeneProduct ncbigene:83496
Ubiquitin carrier protein GeneProduct ncbigene:565498
smad4 GeneProduct ncbigene:30640
msx e GeneProduct uniprot:Q90455
chordin/dino(din) GeneProduct ensembl:ENSDART00000045110
noggin2 GeneProduct ensembl:ENSDART00000063231
deltaNP63/tp73l GeneProduct ncbigene:260407
bmp8 GeneProduct ncbigene:378445
bmp2a GeneProduct ncbigene:30631
goosecoid GeneProduct ensembl:ENSDARG00000059073
gremlin 1 GeneProduct ncbigene:405778
smad1 GeneProduct ncbigene:323405
twsg1b GeneProduct ncbigene:259304
bmpr2 GeneProduct ncbigene:562822
crim1 GeneProduct ensembl:ENSDARG00000029668
bmp4 GeneProduct ncbigene:30612
gremlin 1 GeneProduct ncbigene:405778
admp GeneProduct ncbigene:140619
msx e GeneProduct ncbigene:30527
bmp7/snailhouse (snh) GeneProduct ncbigene:30584
acvrl1/violet beauregarde (vbg) GeneProduct ncbigene:266753
noggin1 GeneProduct ensembl:ENSDART00000081766
bmpr1ba GeneProduct ensembl:ENSDARG00000104100
gata2 GeneProduct ncbigene:30480
bmpr2 GeneProduct ncbigene:555655
bmpr1ab GeneProduct ensembl:ENSDART00000066309
snip1 GeneProduct ncbigene:474374
kheper/zfhx1 GeneProduct ensembl:ENSDART00000047724
follistatin like GeneProduct ensembl:ENSDART00000080772
smad5/somitabun (sbn) GeneProduct ncbigene:30641
msx b GeneProduct ncbigene:30511
follistatin 2 GeneProduct uniprot:Q2PMI4
snai1b GeneProduct ensembl:ENSDARG00000046019
smad4 GeneProduct ensembl:ENSDARG00000023527
prdc GeneProduct ncbigene:550399
tolloid-like 1/mini fin (mfn) GeneProduct ncbigene:474335
noggin3 GeneProduct ncbigene:30173
deltaNP63/tp73l GeneProduct ncbigene:325581
vox GeneProduct ncbigene:64807
gata1/vlad tepes (vlt) GeneProduct ensembl:ENSDARG00000013477
smad6b GeneProduct ensembl:ENSDARG00000031763


  1. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SFG, Corredor-Adámez M, He S, Snaar-Jagalska BE, Spaink HP. BMC Genomics. 2008 Apr 28;9:196. PubMed Europe PMC Scholia
  2. Detection of Smad Signaling in Zebrafish Embryos. Liu X, Wang Q, Meng A. Methods Mol Biol. 2016;1344:275–86. PubMed Europe PMC Scholia