Splicing factor NOVA regulated synaptic proteins (WP1983)

Mus musculus

Synaptic Communication influenced by NOVA-splicing regulation

Authors

Bahar Taneri , Martina Summer-Kutmon , Daniela Digles , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

cadherin mediated signaling pathway

Participants

Label Type Compact URI Comment
PIP2 Metabolite hmdb:HMDB0010032
Cav2.2 GeneProduct ensembl:ENSMUSG00000000058 Validated target - predicted by splicing microarray
4.1G GeneProduct ncbigene:13822 Validated target - predicted by splicing microarray
NIK/Mapk4 GeneProduct ensembl:ENSMUSG00000024558 Validated target - predicted by splicing microarray
N-Cadherin GeneProduct ncbigene:12558
SKIP GeneProduct ncbigene:66354 Validated target - predicted by splicing microarray
Calsyntenin GeneProduct ncbigene:65945 Validated target - predicted by splicing microarray
GIRK2 GeneProduct ncbigene:16522 CLIP predicted target
Clasp1 GeneProduct ensembl:ENSMUSG00000064302 Validated target - predicted by splicing microarray
Slo GeneProduct ncbigene:16531 Validated target - predicted by splicing microarray
CASK GeneProduct ensembl:ENSMUSG00000031012 Validated target - predicted by splicing microarray
neurochondrin GeneProduct ncbigene:26562 Validated target - predicted by splicing microarray
GABAARg2 GeneProduct ncbigene:14406 Validated target
JNK2 GeneProduct ncbigene:26420 Validated target - predicted by CLIP
PMCA1 GeneProduct ncbigene:67972 Validated target - predicted by splicing microarray
Plcb4 GeneProduct ensembl:ENSMUSG00000039943 Validated target - predicted by splicing microarray
Rap1gap GeneProduct ncbigene:110351 Validated target - predicted by splicing microarray
Syntaxin 2 GeneProduct ncbigene:13852 Validated target - predicted by splicing microarray
Camk2g GeneProduct ensembl:ENSMUSG00000021820 Validated target - predicted by splicing microarray
Igsf4a GeneProduct ncbigene:54725 Validated target - predicted by splicing microarray
Neogenin GeneProduct ncbigene:18007 Validated target - predicted by CLIP
Cask GeneProduct ensembl:ENSMUSG00000031012 Validated target - predicted by splicing microarray
Gephrin GeneProduct ncbigene:268566 Validated target - predicted by splicing microarray
Dab1 GeneProduct ensembl:ENSMUSG00000028519 Validated target - predicted by bioinformatics
Aplp2 GeneProduct ensembl:ENSMUSG00000031996 Validated target - predicted by splicing microarray
Kcnq2 GeneProduct ensembl:ENSMUSG00000016346 Validated target - predicted by splicing microarray
Munc18 GeneProduct ncbigene:20911 Validated target - predicted by splicing microarray
4.1R GeneProduct ncbigene:269587 Validated target - predicted by splicing microarray
4.1B GeneProduct ncbigene:13823 Validated target - predicted by splicing microarray
Chl1 GeneProduct ensembl:ENSMUSG00000030077 Validated target - predicted by splicing microarray
Netrin G1 GeneProduct ncbigene:80883 Validated target - predicted by splicing microarray
Rap1 GeneProduct ncbigene:57321
EphrinA5 GeneProduct ncbigene:13640 Validated target - predicted by splicing microarray
NMDAR2B GeneProduct ncbigene:14812 CLIP predicted target
NMDAR1 GeneProduct ncbigene:14810 Validated target - predicted by splicing microarray
Ankyrin G GeneProduct ncbigene:11735 Validated target - predicted by splicing microarray
GluR6 GeneProduct ncbigene:14806 Validated target - predicted by splicing microarray
PKCz GeneProduct ncbigene:18762 CLIP predicted target
GABAB2R GeneProduct ncbigene:242425 CLIP predicted target
4.1N GeneProduct ncbigene:13821 Validated target - predicted by bioinformatics
Igsf4b GeneProduct ncbigene:94332 Validated target - predicted by bioinformatics
MAP4 Protein uniprot:P27546 Validated target - predicted by bioinformatics
AGRIN Protein uniprot:A2ASQ1 Validated target - predicted by splicing microarray
CASK Protein uniprot:P06796 Validated target - predicted by splicing microarray

References

  1. Nova regulates brain-specific splicing to shape the synapse. Ule J, Ule A, Spencer J, Williams A, Hu JS, Cline M, et al. Nat Genet. 2005 Aug;37(8):844–52. PubMed Europe PMC Scholia
  2. An RNA map predicting Nova-dependent splicing regulation. Ule J, Stefani G, Mele A, Ruggiu M, Wang X, Taneri B, et al. Nature. 2006 Nov 30;444(7119):580–6. PubMed Europe PMC Scholia