VEGFR-3 signaling (WP1964)

Rattus norvegicus

Vascular endothelial growth factors are crucial for the vascular development and neovascularization in physiological and pathological processes in both embryo and adult. There are three isoforms of the VEGFR receptor found. This figure shows the VEGFR3 pathway as detected in lymphatic endothelial cells. Activation of the receptor results in proliferation, survival, enhanced permeability and migration of the cell.


Misha Vrolijk , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , and Egon Willighagen


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Rattus norvegicus



Pathway Ontology

vascular endothelial growth factor signaling pathway


Label Type Compact URI Comment
Casp9 GeneProduct ensembl:ENSRNOG00000012944
Mapk3 GeneProduct ensembl:ENSRNOG00000053583
Plcg1 GeneProduct ensembl:ENSRNOG00000051490
Akt1 GeneProduct ensembl:ENSRNOG00000028629
Mapk1 GeneProduct ensembl:ENSRNOG00000001849
Flt4 GeneProduct ncbigene:114110
Shc1 GeneProduct ncbigene:85385
Itpkc GeneProduct ensembl:ENSRNOG00000013945
PI3K GeneProduct ensembl:ENSRNOG00000009385
Vegfc GeneProduct ncbigene:114111
Figf GeneProduct ncbigene:360457
Flt4 GeneProduct ncbigene:114110
Grb2 GeneProduct ncbigene:81504
Bad_v1 GeneProduct ensembl:ENSRNOG00000021147
Nos3 GeneProduct ensembl:ENSRNOG00000009348


  1. Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors. Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K. Oncogene. 1994 Dec;9(12):3545–55. PubMed Europe PMC Scholia
  2. VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis. Hamada K, Oike Y, Takakura N, Ito Y, Jussila L, Dumont DJ, et al. Blood. 2000 Dec 1;96(12):3793–800. PubMed Europe PMC Scholia
  3. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. Mäkinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, et al. EMBO J. 2001 Sep 3;20(17):4762–73. PubMed Europe PMC Scholia
  4. VEGF-receptor signal transduction. Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L. Trends Biochem Sci. 2003 Sep;28(9):488–94. PubMed Europe PMC Scholia
  5. Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity. Galvagni F, Pennacchini S, Salameh A, Rocchigiani M, Neri F, Orlandini M, et al. Circ Res. 2010 Jun 25;106(12):1839–48. PubMed Europe PMC Scholia