Kennedy pathway (WP1771)

Mus musculus

The CDP-choline pathway, first identified by Eugene Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway represents one half of what is known as the Kennedy pathway. The other half is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid product phosphatidylethanolamine (PE). Source: [ Wikipedia]


Kristina Hanspers , Thomas Kelder , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , and Denise Slenter


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Mus musculus



Pathway Ontology

phospholipid metabolic pathway CDP-choline pathway of phosphatidylcholine biosynthesis


Label Type Compact URI Comment
Ethanolamine Metabolite kegg.compound:C00189
SAM Metabolite kegg.compound:C00019
PPi Metabolite chebi:18361
Phosphocholine Metabolite chebi:18132
Sphingolipids Metabolite chebi:26739
Phosphatidylserine Metabolite kegg.compound:C02737
Phosphatidylethanolamine Metabolite kegg.compound:C00350
SAH Metabolite kegg.compound:C00021
CMP Metabolite chebi:17361
ATP Metabolite cas:1927-31-7
Phosphatidylcholines Metabolite cas:8002-43-5
Ethanolamine Metabolite kegg.compound:C00189
L-Serine Metabolite kegg.compound:C00065
ADP Metabolite cas:58-64-0
CDP-choline Metabolite kegg.compound:C00307
L-Serine Metabolite kegg.compound:C00065
Choline Metabolite kegg.compound:C00114
Choline Metabolite kegg.compound:C00114
O-Phosphoethanolamine Metabolite kegg.compound:C00346
AAG Metabolite chebi:73318
CDP-Ethanolamine Metabolite kegg.compound:C00570
CTP Metabolite cas:2056-98-6
Pisd GeneProduct ncbigene:320951
Cept1 GeneProduct ncbigene:99712
Pemt GeneProduct ncbigene:18618
Chkb GeneProduct ncbigene:12651
Sgpl1 GeneProduct ncbigene:20397
Ptdss1 GeneProduct ncbigene:19210
Chka GeneProduct ncbigene:12660
Pcyt1b GeneProduct ncbigene:236899
Pcyt2 GeneProduct ncbigene:68671
Etnk1 GeneProduct ncbigene:75320
Pcyt1a GeneProduct ncbigene:13026
Etnk2 GeneProduct ncbigene:214253
Chpt1 GeneProduct ncbigene:212862
Ptdss2 GeneProduct ncbigene:27388


  1. The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. Gibellini F, Smith TK. IUBMB Life. 2010 Jun;62(6):414–28. PubMed Europe PMC Scholia