Biogenic amine synthesis (WP154)

Danio rerio

Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine. Synthesis pathways for biogenic amines (in blue) follow solid arrows through enzymatic steps, while degradation steps follow the dashed arrows. Source:


Alex Pico , Thomas Kelder , Egon Willighagen , Christine Chichester , Martina Summer-Kutmon , Denise Slenter , and Eric Weitz


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Danio rerio



Pathway Ontology

biogenic amine biosynthetic pathway dopamine degradation pathway


Label Type Compact URI Comment
Acetylserotonin Metabolite wikidata:Q4847704
Epinephrine Metabolite wikidata:Q132621
Tryptophane Metabolite chebi:27897
Choline Metabolite chebi:15354
Serotonin Metabolite chebi:28790
Dopamine Metabolite chebi:18243
Norepinephrine Metabolite chebi:33569
Histamine Metabolite chebi:58432
Melatonin Metabolite chebi:16796
Tyrosine Metabolite chebi:18186
Phenylalanine Metabolite chebi:17295
Acetylcholine Metabolite chebi:15355
Histidine Metabolite chebi:27570
5-Hydroxy-tryptophan Metabolite chebi:17780
L-DOPA Metabolite chebi:15765
GABA Metabolite wikidata:Q210021
Glutamate Metabolite chebi:14321
gad1 GeneProduct ncbigene:378441
HDC GeneProduct ncbigene:793609
aanat1 GeneProduct ncbigene:393677
COMTa GeneProduct ensembl:ENSDARG00000015337
ddc GeneProduct ncbigene:406651
DBH GeneProduct ncbigene:30505
CHAT GeneProduct ncbigene:100170938
tph1 GeneProduct ncbigene:352943
ddc GeneProduct ncbigene:406651
ASMT GeneProduct ensembl:ENSDARG00000098249
pah GeneProduct ncbigene:378962
ache GeneProduct ncbigene:114549
ddc GeneProduct ncbigene:406651
zgc:112198 GeneProduct ncbigene:550403
TH GeneProduct ncbigene:30384
COMPTb GeneProduct ensembl:ENSDARG00000078918