FGF signaling pathway (WP152)

Danio rerio

Fibroblast growth factors, or FGFs, are a family of growth factors, with members involved in angiogenesis, wound healing, embryonic development and various endocrine signaling pathways. The FGFs are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues. Source: Wikipedia (https://en.wikipedia.org/wiki/Fibroblast_growth_factor)


Gabby Krens , Kristina Hanspers , Thomas Kelder , Lou Shaoke , Christine Chichester , Friederike Ehrhart , Alex Pico , Andra Waagmeester , Denise Slenter , Susan Coort , and Egon Willighagen


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Danio rerio



Pathway Ontology

fibroblast growth factor signaling pathway


Label Type Compact URI Comment
Calcium Metabolite hmdb:HMDB0000464
fgf17b GeneProduct ncbigene:407737
dusp6 / mkp3 GeneProduct ncbigene:353314
flh GeneProduct ncbigene:30260
araf GeneProduct ensembl:ENSDARG00000054533
ets1b GeneProduct ensembl:ENSDARG00000053868
pea3 GeneProduct ensembl:ENSDARG00000018303
fgf20a# GeneProduct ncbigene:559630
il17rd / sef GeneProduct ncbigene:171474
ERK2 / mapk1 GeneProduct ncbigene:360144
fgf14# GeneProduct ncbigene:497642
mapkapk2 GeneProduct ncbigene:327321
erk5 / MAPK7 GeneProduct ncbigene:541323
eIF4EB GeneProduct ncbigene:30738
mkk3 GeneProduct ncbigene:65239
fgf17a GeneProduct ncbigene:65089
usf2 GeneProduct ensembl:ENSDARG00000014463
snai1a GeneProduct ensembl:ENSDARG00000056995
mapkapk5 GeneProduct ncbigene:436608
fgf12# GeneProduct ncbigene:497641
fgf13l GeneProduct ncbigene:403003
fgf16# GeneProduct ncbigene:692065
fgf18a GeneProduct ensembl:ENSDARG00000088048
ptpn11a GeneProduct ensembl:ENSDARG00000020334
fgfr4 GeneProduct ncbigene:30706
fgf22# GeneProduct ncbigene:556999
sh3gl1 GeneProduct ncbigene:378838
eEF2K GeneProduct ncbigene:437013
eIF4Ea GeneProduct ncbigene:79380
spry4 GeneProduct ncbigene:114437
srf GeneProduct ensembl:ENSDARG00000053918
fgf8 GeneProduct ncbigene:30538
spry-rp1# GeneProduct ncbigene:336135
atf7a GeneProduct ensembl:ENSDARG00000011298
fgf21 GeneProduct ensembl:ENSDARG00000100846
fgf18b GeneProduct ensembl:ENSDARG00000043962
shcbp1 / shc GeneProduct ensembl:ENSDARG00000102068
mos GeneProduct ncbigene:402817
kRASa GeneProduct ncbigene:393228
ntl GeneProduct ncbigene:30399
ets1a GeneProduct ncbigene:280651
fgf10 GeneProduct ncbigene:359830
p38a / MAPK14a GeneProduct ncbigene:65237
dusp1 / MKP1 GeneProduct ncbigene:406340
fgf2 GeneProduct ensembl:ENSDARG00000075031
sh3glb1 GeneProduct ncbigene:334911
rps6kal GeneProduct ncbigene:337670
cdh1 GeneProduct ncbigene:114424
rasgrf2 GeneProduct ensembl:ENSDARG00000002816
spry4 GeneProduct ncbigene:114437
fgf4 GeneProduct ncbigene:60311
gata5 GeneProduct ncbigene:30482
SP9 GeneProduct ncbigene:405896
mycn GeneProduct ncbigene:252851
casanova / sox32 GeneProduct ncbigene:116990
sox17 GeneProduct ncbigene:30544
nRAS GeneProduct ncbigene:30380
grb2 GeneProduct ncbigene:406308
atf3 GeneProduct ncbigene:393939
nr2f5 GeneProduct ncbigene:30427 the original source is Craf (Dr:22) which links to nr2f5 Entrez Gene ID 30427, but craf (name) is recorded as alias for raf1a ID 30716
fgfr2 GeneProduct ensembl:ENSDARG00000058115
cPLA2 GeneProduct ensembl:ENSDARG00000024546
sp1 GeneProduct ensembl:ENSDARG00000088347
gsc GeneProduct ncbigene:30212
egr2a GeneProduct ncbigene:368241
PLC-gamma# GeneProduct ncbigene:373867
jun GeneProduct ncbigene:327321
sh3gl3 GeneProduct ncbigene:393150
snai1b# GeneProduct ncbigene:30182
fgf23 GeneProduct ncbigene:494456
jnk1 / MAPK8 GeneProduct ncbigene:65236
fgf1 GeneProduct ncbigene:393733
egr1 GeneProduct ncbigene:30498
rps6kb1 GeneProduct ncbigene:406349
PTP1b GeneProduct ncbigene:30081
tbx6 GeneProduct ncbigene:30254
cbl GeneProduct ensembl:ENSDARG00000009958
fgfr1op2 GeneProduct ncbigene:335511
sip GeneProduct ensembl:ENSDARG00000015638
fgf19# GeneProduct ncbigene:368245
fgf10b GeneProduct zfin:ZDB-GENE-060828-1
PKC / itpkc# GeneProduct ncbigene:334077 inositol 1,4,5-trisphosphate 3-kinase C
spry2 GeneProduct ncbigene:335098
creb1a GeneProduct ensembl:ENSDARG00000053586
RAF1l GeneProduct ncbigene:557109 raf1b
fgf5 GeneProduct ncbigene:494454
snai2 GeneProduct ncbigene:494038
mkk4 GeneProduct ncbigene:403052
elk3 GeneProduct ensembl:ENSDARG00000077092
sef / il17rd GeneProduct ensembl:ENSDARG00000038843
Bad GeneProduct ncbigene:58100
gbx2 GeneProduct ncbigene:245948
tak1 GeneProduct ncbigene:553788
sox17 GeneProduct ncbigene:30544
fgfr3 GeneProduct ncbigene:58129
SP8l GeneProduct ncbigene:324931
egr2b GeneProduct ncbigene:30190
spry2 GeneProduct ncbigene:335098
etv5b GeneProduct ensembl:ENSDARG00000044511
fgf7 GeneProduct ncbigene:493181
elk4 / sap1 GeneProduct ensembl:ENSDARG00000077092
sh3gl2 GeneProduct ncbigene:394091
sos1 GeneProduct ensembl:ENSDARG00000100503
sh3glb2 GeneProduct ncbigene:394094
MNK2 / MKNK2 GeneProduct ncbigene:373121
gbx1 GeneProduct ncbigene:142985
rps6ka3a GeneProduct ncbigene:338219 Changed from rps6ka3# to rps6ka3a - the original UniGene ID Dr.21039 links now to human olfactory receptor
bmp4 GeneProduct ncbigene:30612
fgfr1 GeneProduct ncbigene:30705
p38b / MAPK14b GeneProduct ncbigene:266756
fgf11# GeneProduct ncbigene:497640
fgf3 GeneProduct ncbigene:30549
SAPK3 / ERK6 GeneProduct ncbigene:30681
SP8 GeneProduct ncbigene:321264
braf GeneProduct ncbigene:403065
junb GeneProduct ncbigene:407086
fgf6 GeneProduct ncbigene:30560
fgfrl1b GeneProduct ncbigene:497135
aRAFl GeneProduct ncbigene:403063
mek1l GeneProduct ncbigene:406728
fgf24 GeneProduct ncbigene:359831
mkp3 / dusp6 GeneProduct ncbigene:353314
fgf20b# GeneProduct ncbigene:564770
FRS2 GeneProduct ensembl:ENSDARG00000037353
spry-rp1# GeneProduct ncbigene:336584
chrd GeneProduct ncbigene:30161 alias chd
tbx16 GeneProduct ensembl:ENSDARG00000007329
fgfrl1a# GeneProduct ncbigene:393347
ERK1 / mapk3 GeneProduct ncbigene:399480
sh3glb2 GeneProduct ncbigene:402885
atf7b GeneProduct ncbigene:568197
atf2l# GeneProduct ncbigene:378449
sox32 / cas GeneProduct ncbigene:116990
mek2l GeneProduct ncbigene:563181
fos GeneProduct ncbigene:394198
fgf13 GeneProduct ncbigene:492758
pcdh8 GeneProduct ensembl:ENSDARG00000006467
creb1b GeneProduct ensembl:ENSDARG00000093420


  1. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SFG, Corredor-Adámez M, He S, Snaar-Jagalska BE, Spaink HP. BMC Genomics. 2008 Apr 28;9:196. PubMed Europe PMC Scholia