Integrin-mediated cell adhesion (WP1386)

Danio rerio

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]


Thomas Kelder and Daniela Digles


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Danio rerio



Pathway Ontology

integrin mediated signaling pathway


Label Type Compact URI Comment
cdc42l GeneProduct ncbigene:793158 CDC42; cell division cycle 42 (GTP binding protein 25kD)
LOC563639 GeneProduct ncbigene:563639 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
LOC100007176 GeneProduct ncbigene:100007176 SHC3; neuronal Sh
zgc:92074 GeneProduct ncbigene:403063 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
braf GeneProduct ncbigene:403065 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
raf1 GeneProduct ncbigene:30716 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
mapk4 GeneProduct ncbigene:406782 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
mapk7 GeneProduct ncbigene:541323 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2 GeneProduct ncbigene:100169950 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
rac1 GeneProduct ncbigene:327204 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
rac2 GeneProduct ncbigene:415151 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3 GeneProduct ncbigene:437027 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
zgc:153787 GeneProduct ncbigene:768202 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
wu:fk86g11 GeneProduct ncbigene:559145 VAV3; vav 3 oncogene
rock2a GeneProduct ncbigene:317747 ROCK2; Rho-associated coiled-coil containing protein kinase
LOC100002756 GeneProduct ncbigene:100002756 SH3D5; SH3-domain protein 5 (ponsin
DKEY-234H16.4 GeneProduct ncbigene:793882 GIT2; G protein-coupled receptor kinase-interactor 2
pik3r2 GeneProduct ncbigene:404211 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
zgc:171680 GeneProduct ncbigene:564246 ZYX; zyxin
cav1 GeneProduct ncbigene:323695 CAV1; caveolin 1 caveolae protein 22kD
cav2 GeneProduct ncbigene:415240 CAV2; caveolin 2
cav3 GeneProduct ncbigene:449679 CAV3; caveolin 3
fynb GeneProduct ncbigene:574422 FYN; FYN oncogene related to SRC FGR YES [EC:]
grb2 GeneProduct ncbigene:406308 GRB2; growth factor receptor-bound protein 2
sepp1a GeneProduct ncbigene:352931 SEPP1; selenoprotein P plasma
HRAS GeneProduct ncbigene:550286
ptk2.1 GeneProduct ncbigene:142986 PTK2; PTK2 protein tyrosine kinase 2 [EC:
ptk2.1 GeneProduct ncbigene:142986 PTK2; PTK2 protein tyrosine kinase 2 [EC:
rho GeneProduct ncbigene:30295 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
CSK GeneProduct ncbigene:556454 CSK; c-src tyrosine kinase [EC:]
zgc:175192 GeneProduct ncbigene:568309 BCAR1; breast cancer anti-estrogen resistance 1
src GeneProduct ncbigene:325084 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
LOC792354 GeneProduct ncbigene:792354 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
akt2 GeneProduct ncbigene:378972 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
capn2l GeneProduct ncbigene:550505 CAPN2; calpain 2 (m/II) large subunit [EC:]
capn3 GeneProduct ncbigene:447832 CAPN3; calpain 3 (p94) [EC:]
capn7 GeneProduct ncbigene:556792 CAPN7; calpain 7 [EC:
capn9 GeneProduct ncbigene:445107 CAPN9; calpain 9 (nCL-4) [EC:
LOC570311 GeneProduct ncbigene:570311 CAPN10; calpain 10 [EC:
pak2a GeneProduct ncbigene:266749 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
zgc:92014 GeneProduct ncbigene:431769 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
tln1 GeneProduct ncbigene:494453 TLN1; talin 1
zgc:172137 GeneProduct ncbigene:100007679 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
map2k6 GeneProduct ncbigene:65239 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK12 GeneProduct ncbigene:30681 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
LOC560549 GeneProduct ncbigene:560549 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
dock1 GeneProduct ncbigene:572187 DOCK1; dedicator of cyto-kinesis
crk GeneProduct ncbigene:445234 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CH211-127H20.2 GeneProduct ncbigene:558635 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
rap1a GeneProduct ncbigene:415242 RAP1A; RAP1A member of RAS oncogene family
rap1b GeneProduct ncbigene:321107 RAP1B; RAP1B member of RAS oncogene family
mapk1 GeneProduct ncbigene:360144 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
mapk6 GeneProduct ncbigene:565830 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
map2k1 GeneProduct ncbigene:406728 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
zgc:172250 GeneProduct ncbigene:100002225 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
CAPN1 GeneProduct ncbigene:553353 CAPN1; calpain 1 (mu/I) large subunit [EC:]
LOC100151619 GeneProduct ncbigene:100151619
LOC407685 GeneProduct ncbigene:407685
itga5 GeneProduct ncbigene:386787
itga6 GeneProduct ncbigene:503893
zgc:63474 GeneProduct ncbigene:394012
LOC572348 GeneProduct ncbigene:572348
itga2b GeneProduct ncbigene:445380
LOC557935 GeneProduct ncbigene:557935
itgav GeneProduct ncbigene:100151255
LOC557797 GeneProduct ncbigene:557797
itgb3b GeneProduct ncbigene:100001836
ITGB4 GeneProduct ncbigene:335269
itgb5 GeneProduct ncbigene:563556
LOC571984 GeneProduct ncbigene:571984
LOC797491 GeneProduct ncbigene:797491
itgb8 GeneProduct ncbigene:556752
src GeneProduct ncbigene:325084 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
vcl GeneProduct ncbigene:552980 VCL; vinculin
mapk10 GeneProduct ncbigene:569698
pxn GeneProduct ncbigene:399546 PXN; paxillin
ilk GeneProduct ncbigene:393543 ILK; integrin-linked kinase [EC:2.7.1.-]
pak1 GeneProduct ncbigene:373103 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
zgc:162320 GeneProduct ncbigene:555805 VASP; vasodilator-stimulated phosphoprotein
ITGA7 GeneProduct ncbigene:100006255
LOC570868 GeneProduct ncbigene:570868


  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia