Pentose phosphate metabolism (WP134)
Homo sapiens
Pentose phosphate, phosphogluconate, or hexose monophsphate pathway oxidizes glucose-6-phosphate to fructose-6-phosphate and glyceraldehyde-3-P. NADP+ is the electron acceptor. The pathways yields NADPH as well as 5, 4, and 7 carbon intermediaries for synthesis of nucleotides. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
For a description of pathway objects, see the WikiPathways Legend.
Authors
Kdahlquist , Martijn Van Iersel , Kristina Hanspers , Adrien Defay , Alex Pico , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Friederike Ehrhart , Eric Weitz , and Marvin MartensActivity
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Cited In
- Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
- Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease (2020).
- Transcriptional reprogramming of metabolic pathways in critically ill patients (2016).
- Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma (2015).
- Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury (2025).
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Organisms
Homo sapiensCommunities
ONTOXAnnotations
Pathway Ontology
pentose phosphate pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Sedoheptulose-7-Phosphate | Metabolite | cas:2646-35-7 | |
| Fructose-6-Phosphate | Metabolite | cas:643-13-0 | |
| Xylulose-5-Phosphate | Metabolite | cas:60802-29-1 | |
| Glyceraldehyde-3-phosphate | Metabolite | hmdb:HMDB0001112 | |
| D-Ribose-5-Phosphate | Metabolite | cas:3615-55-2 | |
| 6-Phosphogluconate | Metabolite | hmdb:HMDB0001316 | |
| Erythrose-4-Phosphate | Metabolite | hmdb:HMDB0001321 | |
| Ribulose-5-Phosphate | Metabolite | cas:4151-19-3 | |
| Glucose-6-Phosphate | Metabolite | cas:56-73-5 | |
| 6-Phosphonoglucono-delta-lactone | Metabolite | hmdb:HMDB0001127 | |
| Fructose-6-Phosphate | Metabolite | hmdb:HMDB0000124 | |
| G6PD | GeneProduct | ncbigene:2539 | |
| PGLS | GeneProduct | ncbigene:25796 | |
| RPE | GeneProduct | ncbigene:6120 | |
| TALDO1 | GeneProduct | ncbigene:6888 | |
| RPIA | GeneProduct | ncbigene:22934 | |
| TKT | GeneProduct | ncbigene:7086 | |
| PGD | GeneProduct | ncbigene:5226 |