Adipogenesis (WP1331)

Danio rerio

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The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.

Authors

Martijn Van Iersel , Kristina Hanspers , Martina Summer-Kutmon , and Egon Willighagen

Activity

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to development

Participants

Label Type Compact URI Comment
igf1 GeneProduct ncbigene:114433
ptgisl GeneProduct ncbigene:559148
ppardb GeneProduct ncbigene:30754
creb1 GeneProduct ncbigene:573207
GH1 GeneProduct ncbigene:407639
ID3 GeneProduct ncbigene:246093
wnt10b GeneProduct ncbigene:30308
nr3c1 GeneProduct ncbigene:553740
cebpb GeneProduct ncbigene:140814
cyp26a1 GeneProduct ncbigene:30381
cyp26c1 GeneProduct ncbigene:554036
rxraa GeneProduct ncbigene:555578
nr1h3 GeneProduct ncbigene:548341
LPL GeneProduct ncbigene:30354
srebf1 GeneProduct ncbigene:793274
fas GeneProduct ncbigene:768248
rbl1 GeneProduct ncbigene:795522
GATA3 GeneProduct ncbigene:30458
gata2a GeneProduct ncbigene:30480
pparg GeneProduct ncbigene:557037
mef2a GeneProduct ncbigene:30564
MEF2B GeneProduct ncbigene:558180
mef2cb GeneProduct ncbigene:798771
mef2d GeneProduct ncbigene:30580
mif GeneProduct ncbigene:751093
TGFB1 GeneProduct ncbigene:359834
serpine1 GeneProduct ncbigene:100136840
scdb GeneProduct ncbigene:553734
LEP GeneProduct ncbigene:100150233
zgc:109940 GeneProduct ncbigene:553553
gtf3aa GeneProduct ncbigene:445389
rb1 GeneProduct ncbigene:777733
LOC557385 GeneProduct ncbigene:557385
adipoql GeneProduct ncbigene:751715
adfp GeneProduct ncbigene:794841
agt GeneProduct ncbigene:322485
CDKN1A GeneProduct ncbigene:100151416
LOC567485 GeneProduct ncbigene:567485
sp1 GeneProduct ncbigene:324109
LOC100001938 GeneProduct ncbigene:100001938
GADD45A GeneProduct ncbigene:431763
GADD45B GeneProduct ncbigene:406304
cebpd GeneProduct ncbigene:140817
bmp1a GeneProduct ensembl:ENSDARG00000028071
bmp2b GeneProduct ncbigene:30632
zgc:153939 GeneProduct ncbigene:777717
bmp4 GeneProduct ncbigene:30612
FOXO1A GeneProduct ncbigene:768121
LOC100006043 GeneProduct ncbigene:100006043
ppargc1al GeneProduct ncbigene:553418
ncoa1 GeneProduct ncbigene:563288
ncoa2 GeneProduct ncbigene:81884
pparab GeneProduct ncbigene:557714
stat3 GeneProduct ncbigene:30767
STAT2 GeneProduct ncbigene:565200
stat1a GeneProduct ncbigene:30768
LOC566983 GeneProduct ncbigene:566983
socs1 GeneProduct ncbigene:445073
cntfr GeneProduct ncbigene:368438
il6st GeneProduct ncbigene:100006778
mbnl1 GeneProduct ncbigene:767696
ctnnb1 GeneProduct ncbigene:30265
wnt5b GeneProduct ncbigene:30105
wnt1 GeneProduct ncbigene:30128
smad3b GeneProduct ncbigene:326283
FZD1 GeneProduct ncbigene:30365
LOC560032 GeneProduct ncbigene:560032
hnf1a GeneProduct ncbigene:266961
frzb GeneProduct ncbigene:30119
ins GeneProduct ncbigene:30262
LOC797300 GeneProduct ncbigene:797300
zgc:76966 GeneProduct ncbigene:405805
gata4 GeneProduct ncbigene:30483
nr2f1a GeneProduct ncbigene:30418
roraa GeneProduct ncbigene:564951
cugbp1 GeneProduct ncbigene:58137
hif1ab GeneProduct ncbigene:393202
copeb GeneProduct ncbigene:280650
KLF7 GeneProduct ncbigene:553670
ncor1 GeneProduct ncbigene:393246
ncor2 GeneProduct ncbigene:561503
zgc:111859 GeneProduct ncbigene:335901
egr2b GeneProduct ncbigene:30190
LOC565310 GeneProduct ncbigene:565310
epas1 GeneProduct ncbigene:555192
ahr1b GeneProduct ncbigene:554265
wwtr1 GeneProduct ncbigene:568008
si:ch211-134j6.3 GeneProduct ncbigene:563003
LOC559281 GeneProduct ncbigene:559281
zgc:123260 GeneProduct ncbigene:567403
lmna GeneProduct ncbigene:195815
AGPAT2 GeneProduct ncbigene:777624
zmpste24 GeneProduct ncbigene:334380
lpin1 GeneProduct ncbigene:799099
LOC558422 GeneProduct ncbigene:558422
pck1 GeneProduct ncbigene:378727
zgc:77867 GeneProduct ncbigene:406473
cebpa GeneProduct ncbigene:140815
e2f4 GeneProduct ncbigene:406741

References

  1. Molecular regulation of adipogenesis. Rosen ED, Spiegelman BM. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia