Estrogen metabolism (WP1302)

Rattus norvegicus

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads

Authors

Kristina Hanspers , Martina Summer-Kutmon , and Susan Coort

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

steroid metabolic pathway

Participants

Label Type Compact URI Comment
2-Hydroxyestrone Metabolite hmdb:HMDB0000343
Estrone Metabolite hmdb:HMDB0000145
2-Hydroxyestradiol Metabolite hmdb:HMDB0000338
Estrone sulfate Metabolite hmdb:HMDB0001425
Oxygen Metabolite hmdb:HMDB0001377
Oxygen Metabolite hmdb:HMDB0001377
Oxygen Metabolite hmdb:HMDB0001377
Oxygen Metabolite hmdb:HMDB0001377
Estrone-2,3-quinone Metabolite pubchem.compound:148381
16a-Hydroxyestrone Metabolite hmdb:HMDB0000335
2-Methoxyestrone 3-glucuronide Metabolite hmdb:HMDB0004482
Estradiol-3-glucuronide Metabolite hmdb:HMDB0006224
Superoxide Metabolite hmdb:HMDB0002168
Superoxide Metabolite hmdb:HMDB0002168
2-Methoxyestradiol Metabolite hmdb:HMDB0000405
Superoxide Metabolite hmdb:HMDB0002168
Estrone-17-glucuronide Metabolite hmdb:HMDB0004483
4-Methoxyestradiol Metabolite hmdb:HMDB0000405
Estrone-3-glucuronide Metabolite hmdb:HMDB0004483
Superoxide Metabolite hmdb:HMDB0002168
2-Methoxyestrone Metabolite hmdb:HMDB0000010
Estrone-3,4-quinone Metabolite pubchem.compound:114862
Comt GeneProduct ensembl:ENSRNOG00000001889
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Cyp1a2 GeneProduct ensembl:ENSRNOG00000016173
Ugt1a1 GeneProduct ncbigene:24861
Ugt1a1 GeneProduct ncbigene:24861
Ste GeneProduct ensembl:ENSRNOG00000001957
Comt GeneProduct ensembl:ENSRNOG00000001889
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
Arse GeneProduct ensembl:ENSRNOG00000028350
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Nqo1 GeneProduct ensembl:ENSRNOG00000012772
Ugt1a1 GeneProduct ncbigene:24861
Cyp1a1 GeneProduct ensembl:ENSRNOG00000019500
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Comt GeneProduct ensembl:ENSRNOG00000001889
UGT1A9 GeneProduct ncbigene:396552
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Ugt1a1 GeneProduct ncbigene:24861
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Comt GeneProduct ensembl:ENSRNOG00000001889
UGT1A9 GeneProduct ncbigene:396552
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Cyp1a2 GeneProduct ensembl:ENSRNOG00000016173
Ugt1a1 GeneProduct ncbigene:24861
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Ugt1a2 GeneProduct ncbigene:396527
GSTM1 GeneProduct ncbigene:24423
Sts GeneProduct ncbigene:24800
Cyp1a1 GeneProduct ensembl:ENSRNOG00000019500
Nqo1 GeneProduct ensembl:ENSRNOG00000012772
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Ugt1a1 GeneProduct ncbigene:24861
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
Cyp1b1 GeneProduct ensembl:ENSRNOG00000040287

References

  1. Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10937–42. PubMed Europe PMC Scholia
  2. Estrogen metabolism by conjugation. Raftogianis R, Creveling C, Weinshilboum R, Weisz J. J Natl Cancer Inst Monogr. 2000;(27):113–24. PubMed Europe PMC Scholia
  3. 2-Methoxyestradiol, a promising anticancer agent. Lakhani NJ, Sarkar MA, Venitz J, Figg WD. Pharmacotherapy. 2003 Feb;23(2):165–72. PubMed Europe PMC Scholia
  4. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM. Mol Endocrinol. 2003 Jul;17(7):1344–55. PubMed Europe PMC Scholia
  5. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, et al. Carcinogenesis. 2003 Apr;24(4):697–702. PubMed Europe PMC Scholia
  6. Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Guillemette C, Bélanger A, Lépine J. Breast Cancer Res. 2004;6(6):246–54. PubMed Europe PMC Scholia
  7. Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. Abel EL, Lyon RP, Bammler TK, Verlinde CLMJ, Lau SS, Monks TJ, et al. Chem Biol Interact. 2004 Dec 30;151(1):21–32. PubMed Europe PMC Scholia
  8. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL. Breast Cancer Res. 2005;7(6):R909-21. PubMed Europe PMC Scholia