ErbB signaling pathway (WP1299)

Rattus norvegicus

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors. The ErbB protein family consists of 4 members * ErbB-1, also named epidermal growth factor receptor (EGFR) * ErbB-2, also named HER2 in humans and neu in rodents * ErbB-3, also named HER3 and * ErbB-4, also named HER4 The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


Christine Chichester , Martina Summer-Kutmon , Friederike Ehrhart , Lauren J. Dupuis , and Marvin Martens


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Rattus norvegicus



Disease Ontology

multiple sclerosis Alzheimer's disease cancer

Pathway Ontology

epidermal growth factor/neuregulin signaling pathway


Label Type Compact URI Comment
Shc2 GeneProduct ncbigene:314612
Gsk3b GeneProduct ncbigene:84027
Nrg4 GeneProduct ncbigene:690919
Pik3r5 GeneProduct ncbigene:497931
Erbb4 GeneProduct ncbigene:59323
Akt3 GeneProduct ensembl:ENSRNOG00000021497
Plcg1 GeneProduct ncbigene:25738
Btc GeneProduct ncbigene:64022
Mapk8 GeneProduct ncbigene:116554
Erbb3 GeneProduct ncbigene:29496
Nrg1 GeneProduct ncbigene:112400
Egfr GeneProduct ncbigene:24329
Erbb2 GeneProduct ncbigene:24337
Araf GeneProduct ncbigene:64363
Bad GeneProduct ncbigene:64639
AREG GeneProduct ncbigene:29183
Gab1 GeneProduct ncbigene:361388
Elk1 GeneProduct ncbigene:314436
Tgfa GeneProduct ncbigene:24827
Sos1 GeneProduct ncbigene:313845
Erbb2 GeneProduct ncbigene:24337
Src GeneProduct ncbigene:83805
Grb2 GeneProduct ncbigene:81504
Nrg3 GeneProduct ncbigene:498596
Ereg GeneProduct ncbigene:59325
Erbb2 GeneProduct ncbigene:24337
Grb2 GeneProduct ncbigene:81504
Myc GeneProduct ncbigene:24577
Stat5a GeneProduct ncbigene:24918
Cdkn1a GeneProduct ncbigene:114851
Map2k1 GeneProduct ncbigene:170851
Jun GeneProduct ncbigene:24516
Erbb4 GeneProduct ncbigene:59323
Hbegf GeneProduct ncbigene:25433
Egf GeneProduct ncbigene:25313
Eif4ebp1 GeneProduct ncbigene:116636
Erbb2 GeneProduct ncbigene:24337
Egfr GeneProduct ncbigene:24329
Crk GeneProduct ncbigene:54245
Erbb2 GeneProduct ncbigene:24337
Erbb4 GeneProduct ncbigene:59323
Erbb3 GeneProduct ncbigene:29496
Prkca GeneProduct ncbigene:24680
Rps6kb1 GeneProduct ncbigene:83840
Cdkn1b GeneProduct ncbigene:83571
Camk2a GeneProduct ensembl:ENSRNOG00000018712
Mtor GeneProduct ncbigene:56718
Hras GeneProduct ncbigene:293621
Stat5a GeneProduct ncbigene:24918
Cblc GeneProduct ncbigene:292699
Pak4 GeneProduct ncbigene:292756
Nck1 GeneProduct ncbigene:300955
Map2k7 GeneProduct ncbigene:363855
Egfr GeneProduct ncbigene:24329
Mapk1 GeneProduct ncbigene:116590
Erbb3 GeneProduct ncbigene:29496
Ptk2 GeneProduct ncbigene:25614
Abl1 GeneProduct ncbigene:311860
Nrg2 GeneProduct ncbigene:432361
Elk1 GeneProduct ncbigene:314436