Estrogen signaling (WP1279)

Rattus norvegicus

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Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Authors

Kristina Hanspers

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

estrogen signaling pathway

Participants

Label Type Compact URI Comment
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Cyclic AMP Metabolite hmdb:HMDB0000058
Hdac2 GeneProduct ncbigene:84577 HDAC2; histone deacetylase 2
Mapk9 GeneProduct ncbigene:50658
ERCC2 GeneProduct ncbigene:308415
Taf7 GeneProduct ncbigene:307485
Taf13 GeneProduct ncbigene:310784
Sin3a GeneProduct ncbigene:363067
Mapk1 GeneProduct ensembl:ENSRNOG00000001849
Mnat1 GeneProduct ncbigene:266713
Ccnd1 GeneProduct ncbigene:58919
Gtf2b GeneProduct ncbigene:81673
Bcl2 GeneProduct ncbigene:24224
Polr2i GeneProduct ncbigene:292778
Hdac3 GeneProduct ncbigene:84578 HDAC3; histone deacetylase 3
Ercc3 GeneProduct ncbigene:291703
Esr1 GeneProduct ncbigene:24890
Creb1 GeneProduct ncbigene:81646
Esr1 GeneProduct ncbigene:24890
Ep300 GeneProduct ncbigene:170915
Ikbkb GeneProduct ensembl:ENSRNOG00000019073
Esr1 GeneProduct ncbigene:24890
POLR2H GeneProduct ncbigene:498109
Polr2b GeneProduct ncbigene:289561
Esr1 GeneProduct ncbigene:24890
Prkaca GeneProduct ncbigene:25636
Polr2c GeneProduct ncbigene:361365
TAF12 GeneProduct ncbigene:682902
Cdk7 GeneProduct ncbigene:171150
Jun GeneProduct ncbigene:24516
Hdac7 GeneProduct ncbigene:84582 HDAC7A; histone deacetylase 7
Brca1 GeneProduct ncbigene:497672
Akt1 GeneProduct ncbigene:24185
Gtf2e1 GeneProduct ncbigene:303918
Hdac6 GeneProduct ncbigene:84581 HDAC6; histone deacetylase 6
Taf9 GeneProduct ncbigene:373541
Polr2e GeneProduct ncbigene:690966
Gtf2h4 GeneProduct ncbigene:294236
Gtf2h1 GeneProduct ncbigene:361580
Gnb1 GeneProduct ncbigene:24400
Gtf2a2 GeneProduct ncbigene:83828
Gtf2e2 GeneProduct ncbigene:306516
Src GeneProduct ncbigene:83805
Bcl2 GeneProduct ncbigene:24224
LOC367858 GeneProduct ensembl:ENSRNOG00000016611
Gtf2f2 GeneProduct ncbigene:81674
Ikbkg GeneProduct ensembl:ENSRNOG00000037237
Creb1 GeneProduct ncbigene:81646
Esr1 GeneProduct ncbigene:24890
Esr1 GeneProduct ncbigene:24890
Polr2j GeneProduct ncbigene:288588
Sos1 GeneProduct ncbigene:313845
Braf GeneProduct ncbigene:114486
Map2k1 GeneProduct ensembl:ENSRNOG00000010176
Esr1 GeneProduct ncbigene:24890
Mapk14 GeneProduct ncbigene:81649
Nfkb1 GeneProduct ncbigene:81736
Elk1 GeneProduct ncbigene:314436
Nfkb1 GeneProduct ncbigene:81736
Shc2 GeneProduct ncbigene:314612
Hdac1 GeneProduct ncbigene:297893 HDAC1; histone deacetylase 1
Taf6 GeneProduct ncbigene:288533
Tbp GeneProduct ncbigene:117526
Gtf2a2 GeneProduct ncbigene:83828
POLR2K GeneProduct ncbigene:309224
Crebbp GeneProduct ncbigene:54244
Gper GeneProduct ncbigene:171104
Fos GeneProduct ncbigene:314322
Polr2f GeneProduct ncbigene:83503
Grb2 GeneProduct ncbigene:81504
Ilk GeneProduct ncbigene:170922
Gtf2h2 GeneProduct ncbigene:294693
Taf5 GeneProduct ncbigene:294018
Esr1 GeneProduct ncbigene:24890
Gngt1 GeneProduct ncbigene:680149
Polr2g GeneProduct ncbigene:117017
HDAC5 GeneProduct ncbigene:84580 HDAC5; histone deacetylase 5
Esr1 GeneProduct ncbigene:24890
Hdac8 GeneProduct ncbigene:363481 HDAC8; histone deacetylase
Tbp GeneProduct ncbigene:117526
Hdac4 GeneProduct ncbigene:363287 HDAC4; histone deacetylase 4
Gtf2h3 GeneProduct ncbigene:288651
Polr2a GeneProduct ncbigene:363633
Ccnh GeneProduct ncbigene:84389
Sp1 GeneProduct ncbigene:24790
NP_001101058.1 GeneProduct ensembl:ENSRNOG00000022485

References