Estrogen metabolism (WP1264)

Mus musculus

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads

Authors

Kristina Hanspers , Martina Summer-Kutmon , and Susan Coort

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

steroid metabolic pathway

Participants

Label Type Compact URI Comment
2-Hydroxyestrone Metabolite hmdb:HMDB0000343
Estrone Metabolite hmdb:HMDB0000145
2-Hydroxyestradiol Metabolite hmdb:HMDB0000338
Estrone sulfate Metabolite hmdb:HMDB0001425
Oxygen Metabolite hmdb:HMDB0001377
Oxygen Metabolite hmdb:HMDB0001377
Estradiol Metabolite hmdb:HMDB0000151
Oxygen Metabolite hmdb:HMDB0001377
Oxygen Metabolite hmdb:HMDB0001377
Estrone-2,3-quinone Metabolite pubchem.compound:148381
16a-Hydroxyestrone Metabolite hmdb:HMDB0000335
2-Methoxyestrone 3-glucuronide Metabolite hmdb:HMDB0004482
Estradiol-3-glucuronide Metabolite hmdb:HMDB0006224
Superoxide Metabolite hmdb:HMDB0002168
Superoxide Metabolite hmdb:HMDB0002168
2-Methoxyestradiol Metabolite hmdb:HMDB0000405
Superoxide Metabolite hmdb:HMDB0002168
Estrone-17-glucuronide Metabolite hmdb:HMDB0004483
4-Methoxyestradiol Metabolite hmdb:HMDB0000405
Estrone-3-glucuronide Metabolite hmdb:HMDB0004483
Superoxide Metabolite hmdb:HMDB0002168
2-Methoxyestrone Metabolite hmdb:HMDB0000010
Estrone-3,4-quinone Metabolite pubchem.compound:114862
Comt1 GeneProduct ensembl:ENSMUSG00000000326
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Cyp1a2 GeneProduct ensembl:ENSMUSG00000032310
Ugt1a1 GeneProduct ncbigene:394436
Ugt1a1 GeneProduct ncbigene:394436
Sult1e1 GeneProduct ensembl:ENSMUSG00000029272
Comt1 GeneProduct ensembl:ENSMUSG00000000326
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Sult1a1 GeneProduct ensembl:ENSMUSG00000030711
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Nqo1 GeneProduct ensembl:ENSMUSG00000003849
Ugt1a1 GeneProduct ncbigene:394436
Cyp1a1 GeneProduct ensembl:ENSMUSG00000032315
Sult1a1 GeneProduct ensembl:ENSMUSG00000030711
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Comt1 GeneProduct ensembl:ENSMUSG00000000326
Ugt1a9 GeneProduct ncbigene:394434
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Ugt1a1 GeneProduct ncbigene:394436
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Comt1 GeneProduct ensembl:ENSMUSG00000000326
Ugt1a9 GeneProduct ncbigene:394434
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Cyp1a2 GeneProduct ensembl:ENSMUSG00000032310
Gsta1 GeneProduct ncbigene:14857
Ugt1a1 GeneProduct ncbigene:394436
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Ugt1a2 GeneProduct ncbigene:22236
Gstm1 GeneProduct ncbigene:14862
Cyp1a1 GeneProduct ensembl:ENSMUSG00000032315
Nqo1 GeneProduct ensembl:ENSMUSG00000003849
Ugt1a10 GeneProduct ensembl:ENSMUSG00000054545
Ugt1a1 GeneProduct ncbigene:394436
Sult1a1 GeneProduct ensembl:ENSMUSG00000030711
Cyp1b1 GeneProduct ensembl:ENSMUSG00000024087

References

  1. Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10937–42. PubMed Europe PMC Scholia
  2. Estrogen metabolism by conjugation. Raftogianis R, Creveling C, Weinshilboum R, Weisz J. J Natl Cancer Inst Monogr. 2000;(27):113–24. PubMed Europe PMC Scholia
  3. 2-Methoxyestradiol, a promising anticancer agent. Lakhani NJ, Sarkar MA, Venitz J, Figg WD. Pharmacotherapy. 2003 Feb;23(2):165–72. PubMed Europe PMC Scholia
  4. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM. Mol Endocrinol. 2003 Jul;17(7):1344–55. PubMed Europe PMC Scholia
  5. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, et al. Carcinogenesis. 2003 Apr;24(4):697–702. PubMed Europe PMC Scholia
  6. Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Guillemette C, Bélanger A, Lépine J. Breast Cancer Res. 2004;6(6):246–54. PubMed Europe PMC Scholia
  7. Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. Abel EL, Lyon RP, Bammler TK, Verlinde CLMJ, Lau SS, Monks TJ, et al. Chem Biol Interact. 2004 Dec 30;151(1):21–32. PubMed Europe PMC Scholia
  8. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL. Breast Cancer Res. 2005;7(6):R909-21. PubMed Europe PMC Scholia