ErbB signaling pathway (WP1261)

Mus musculus

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors. The ErbB protein family consists of 4 members * ErbB-1, also named epidermal growth factor receptor (EGFR) * ErbB-2, also named HER2 in humans and neu in rodents * ErbB-3, also named HER3 and * ErbB-4, also named HER4 The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


Christine Chichester , Friederike Ehrhart , and Marvin Martens


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Mus musculus



Pathway Ontology

epidermal growth factor/neuregulin signaling pathway

Disease Ontology

cancer multiple sclerosis Alzheimer's disease


Label Type Compact URI Comment
Shc2 GeneProduct ncbigene:216148
Gsk3b GeneProduct ncbigene:56637
Nrg4 GeneProduct ncbigene:83961
Pik3r5 GeneProduct ncbigene:320207
Erbb4 GeneProduct ncbigene:13869
Akt3 GeneProduct ncbigene:23797
Plcg1 GeneProduct ncbigene:18803
Btc GeneProduct ncbigene:12223
Mapk8 GeneProduct ncbigene:26419
Erbb3 GeneProduct ncbigene:13867
Nrg1 GeneProduct ncbigene:211323
Egfr GeneProduct ncbigene:13649
Erbb2 GeneProduct ncbigene:13866
Araf GeneProduct ncbigene:11836
Bad GeneProduct ncbigene:12015
Areg GeneProduct ncbigene:11839
Gab1 GeneProduct ncbigene:14388
Elk1 GeneProduct ncbigene:13712
Tgfa GeneProduct ncbigene:21802
Sos1 GeneProduct ncbigene:20662
Erbb2 GeneProduct ncbigene:13866
Src GeneProduct ncbigene:20779
Grb2 GeneProduct ncbigene:14784
Nrg3 GeneProduct ncbigene:18183
Ereg GeneProduct ncbigene:13874
Erbb2 GeneProduct ncbigene:13866
Grb2 GeneProduct ncbigene:14784
Myc GeneProduct ncbigene:17869
Stat5a GeneProduct ncbigene:20850
Cdkn1a GeneProduct ncbigene:12575
Map2k1 GeneProduct ncbigene:26395
Jun GeneProduct ncbigene:16476
Erbb4 GeneProduct ncbigene:13869
Hbegf GeneProduct ncbigene:15200
Egf GeneProduct ncbigene:13645
Eif4ebp1 GeneProduct ncbigene:13685
Erbb2 GeneProduct ncbigene:13866
Egfr GeneProduct ncbigene:13649
Crk GeneProduct ncbigene:12928
Erbb2 GeneProduct ncbigene:13866
Erbb4 GeneProduct ncbigene:13869
Erbb3 GeneProduct ncbigene:13867
Prkca GeneProduct ncbigene:18750
Cdkn1b GeneProduct ncbigene:12576
Camk2a GeneProduct ncbigene:12322
Mtor GeneProduct ncbigene:56717
Hras1 GeneProduct ncbigene:15461
Stat5a GeneProduct ncbigene:20850
Cblc GeneProduct ncbigene:80794
Pak4 GeneProduct ncbigene:70584
Nck1 GeneProduct ncbigene:17973
Map2k7 GeneProduct ncbigene:26400
Egfr GeneProduct ncbigene:13649
Mapk1 GeneProduct ncbigene:26413
Erbb3 GeneProduct ncbigene:13867
Ptk2 GeneProduct ncbigene:14083
Abl1 GeneProduct ncbigene:11350
LOC100042150 GeneProduct ncbigene:100042150
Elk1 GeneProduct ncbigene:13712