Estrogen signaling (WP1244)
Mus musculus
Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Kristina Hanspers , Christine Chichester , and Finterly HuActivity
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Cited In
- Proteomic profiling of salivary gland after nonviral gene transfer mediated by conventional plasmids and minicircles (2014).
- A provisional gene regulatory atlas for mouse heart development (2014).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
estrogen signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Estradiol | Metabolite | hmdb:HMDB0000151 | |
| Cyclic AMP | Metabolite | hmdb:HMDB0000058 | |
| Hdac2 | GeneProduct | ncbigene:15182 | HDAC2; histone deacetylase 2 |
| Mapk9 | GeneProduct | ncbigene:26420 | |
| Ercc2 | GeneProduct | ncbigene:13871 | |
| Taf7 | GeneProduct | ncbigene:24074 | |
| Taf13 | GeneProduct | ncbigene:99730 | |
| Sin3a | GeneProduct | ncbigene:20466 | |
| Mapk1 | GeneProduct | ensembl:ENSMUSG00000063358 | |
| Mnat1 | GeneProduct | ncbigene:17420 | |
| Ccnd1 | GeneProduct | ncbigene:12443 | |
| Gtf2b | GeneProduct | ncbigene:229906 | |
| Bcl2 | GeneProduct | ncbigene:12043 | |
| Polr2i | GeneProduct | ncbigene:69920 | |
| Hdac3 | GeneProduct | ncbigene:15183 | HDAC3; histone deacetylase 3 |
| Ercc3 | GeneProduct | ncbigene:13872 | |
| Esr1 | GeneProduct | ncbigene:13982 | |
| Creb1 | GeneProduct | ncbigene:12912 | |
| Pik3ca | GeneProduct | ncbigene:18706 | |
| Ep300 | GeneProduct | ncbigene:328572 | |
| Ikbkb | GeneProduct | ensembl:ENSMUSG00000031537 | |
| Ncor1 | GeneProduct | ncbigene:20185 | |
| Polr2h | GeneProduct | ncbigene:245841 | |
| Polr2b | GeneProduct | ncbigene:231329 | |
| Prkaca | GeneProduct | ncbigene:18747 | |
| Polr2c | GeneProduct | ncbigene:20021 | |
| Taf12 | GeneProduct | ncbigene:66464 | |
| Cdk7 | GeneProduct | ncbigene:12572 | |
| Jun | GeneProduct | ncbigene:16476 | |
| Gnas | GeneProduct | ncbigene:14683 | |
| Hdac7 | GeneProduct | ncbigene:56233 | HDAC7A; histone deacetylase 7 |
| Brca1 | GeneProduct | ncbigene:12189 | |
| Akt1 | GeneProduct | ncbigene:11651 | |
| Gtf2e1 | GeneProduct | ncbigene:74197 | |
| Hdac6 | GeneProduct | ncbigene:15185 | HDAC6; histone deacetylase 6 |
| Taf9 | GeneProduct | ncbigene:108143 | |
| Polr2e | GeneProduct | ncbigene:66420 | |
| Gtf2h4 | GeneProduct | ncbigene:14885 | |
| Gtf2h1 | GeneProduct | ncbigene:14884 | |
| Gnb1 | GeneProduct | ncbigene:14688 | |
| Gtf2a2 | GeneProduct | ncbigene:235459 | |
| Gtf2e2 | GeneProduct | ncbigene:68153 | |
| Src | GeneProduct | ncbigene:20779 | |
| Hras1 | GeneProduct | ensembl:ENSMUSG00000025499 | |
| Gtf2f2 | GeneProduct | ncbigene:68705 | |
| Ikbkg | GeneProduct | ensembl:ENSMUSG00000004221 | |
| Polr2j | GeneProduct | ncbigene:20022 | |
| Sos1 | GeneProduct | ncbigene:20662 | |
| Braf | GeneProduct | ncbigene:109880 | |
| Map2k1 | GeneProduct | ensembl:ENSMUSG00000004936 | |
| Mapk14 | GeneProduct | ncbigene:26416 | |
| Nfkb1 | GeneProduct | ncbigene:18033 | |
| Elk1 | GeneProduct | ncbigene:13712 | |
| Shc2 | GeneProduct | ncbigene:216148 | |
| Hdac1 | GeneProduct | ncbigene:433759 | HDAC1; histone deacetylase 1 |
| Taf6 | GeneProduct | ncbigene:21343 | |
| Tbp | GeneProduct | ncbigene:21374 | |
| Polr2k | GeneProduct | ncbigene:17749 | |
| Crebbp | GeneProduct | ncbigene:12914 | |
| Gper | GeneProduct | ncbigene:76854 | |
| Fos | GeneProduct | ncbigene:14281 | |
| Polr2f | GeneProduct | ncbigene:69833 | |
| Grb2 | GeneProduct | ncbigene:14784 | |
| Ilk | GeneProduct | ncbigene:16202 | |
| Gtf2h2 | GeneProduct | ncbigene:23894 | |
| Taf5 | GeneProduct | ncbigene:226182 | |
| Gngt1 | GeneProduct | ncbigene:14699 | |
| Polr2g | GeneProduct | ncbigene:67710 | |
| Hdac5 | GeneProduct | ncbigene:15184 | HDAC5; histone deacetylase 5 |
| Hdac8 | GeneProduct | ncbigene:70315 | HDAC8; histone deacetylase |
| Hdac4 | GeneProduct | ncbigene:208727 | HDAC4; histone deacetylase 4 |
| Gtf2h3 | GeneProduct | ncbigene:209357 | |
| Polr2a | GeneProduct | ncbigene:20020 | |
| Ccnh | GeneProduct | ncbigene:66671 | |
| Sp1 | GeneProduct | ncbigene:20683 | |
| Chuk | GeneProduct | ensembl:ENSMUSG00000025199 |