Osteoclast signaling (WP12)

Homo sapiens

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Signaling pathways involved in osteoclast activation. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Ed Hsiao , Alex Pico , Samuel Sklar , Kristina Hanspers , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Jesse Vercoulen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to development signaling pathway

Cell Type Ontology

osteoclast

Participants
Query Drugst.One

Label Type Compact URI Comment
Ca²⁺ Metabolite pubchem.compound:271
H⁺ Metabolite pubchem.compound:1038
Pi Metabolite chebi:35780
Na⁺ Metabolite hmdb:HMDB0000588
AIMP2 GeneProduct ensembl:ENSG00000106305
MAPK8 GeneProduct ensembl:ENSG00000107643
OPG Protein ncbigene:4982
PDGFB Protein ncbigene:5155
TRPV Protein ncbigene:56302
RANK ligand Protein ncbigene:8600
TRAP Protein ncbigene:54
Cathepsin K Protein ncbigene:1513
IFN-b Protein ncbigene:3456
Na+/H+ transporter Protein ncbigene:6548
H+ ATPase Protein ncbigene:9550
RANK Protein ncbigene:8792
Type 1 interferon receptor Protein ncbigene:3454
b3 integrin Protein ncbigene:3690
OGR1 Protein ncbigene:8111
Osteopontin Protein ncbigene:6696

References

  1. Osteoclast differentiation and activation. Boyle WJ, Simonet WS, Lacey DL. Nature. 2003 May 15;423(6937):337–42. PubMed Europe PMC Scholia