Monoamine GPCRs (WP1193)

Canis familiaris

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [ Monoamine neurotransmitters]


Egon Willighagen , Elisa Cirillo , and Kristina Hanspers


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Canis familiaris



Pathway Ontology

signaling pathway G protein mediated signaling pathway


Label Type Compact URI Comment
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Acetylcholine Metabolite hmdb:HMDB0000895
Muscarine Metabolite pubchem.compound:9308
HRH1 GeneProduct ncbigene:403813
ADRA2C GeneProduct ncbigene:488793
HTR4 GeneProduct ncbigene:489198
DRD3 GeneProduct ncbigene:487984
HRH2 GeneProduct ncbigene:403812
CHRM3 GeneProduct ncbigene:403827
ADRA1A GeneProduct ncbigene:403866
DRD5 GeneProduct ncbigene:488824
DRD4 GeneProduct ncbigene:448805
ADRB3 GeneProduct ncbigene:442979
ADRA1B GeneProduct ncbigene:403962
CHRM2 GeneProduct ncbigene:403858
HTR6 GeneProduct ncbigene:487402
HTR1D GeneProduct ncbigene:403963
CHRM1 GeneProduct ncbigene:483776
HTR1E GeneProduct ncbigene:481907
HTR7 GeneProduct ncbigene:477762
CHRM4 GeneProduct ncbigene:611314
DRD2 GeneProduct ncbigene:403701
CHRM5 GeneProduct ncbigene:487472
ADRA2A GeneProduct ncbigene:486888
HTR2A GeneProduct ncbigene:403882
DRD1 GeneProduct ncbigene:489110
HTR5A GeneProduct ncbigene:482814
ADRB1 GeneProduct ncbigene:493972
ADRA2B GeneProduct ncbigene:611658
HTR2C GeneProduct ncbigene:450240
HTR2B GeneProduct ncbigene:403881
HTR1A GeneProduct ncbigene:487230
ADRA1D GeneProduct ncbigene:552897
HTR1B GeneProduct ncbigene:403741
ADRB2 GeneProduct ncbigene:403910