Integrin-mediated cell adhesion (WP1185)

Canis familiaris

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]


Thomas Kelder and Daniela Digles


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Canis familiaris



Pathway Ontology

integrin mediated signaling pathway


Label Type Compact URI Comment
CDC42 GeneProduct ncbigene:607535 CDC42; cell division cycle 42 (GTP binding protein 25kD)
SHC1 GeneProduct ncbigene:490439 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
LOC476352 GeneProduct ncbigene:476352 SHC3; neuronal Sh
ARAF GeneProduct ncbigene:491857 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
BRAF GeneProduct ncbigene:475526 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
RAF1 GeneProduct ncbigene:484648 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
MAPK4 GeneProduct ncbigene:491690 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK7 GeneProduct ncbigene:489532 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
CAPNS1 GeneProduct ncbigene:611746 CAPNS1; calpain small subunit 1 [EC:]
MYLK2 GeneProduct ncbigene:477187 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
ARHGEF7 GeneProduct ncbigene:485552 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
RAC1 GeneProduct ncbigene:403955 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2 GeneProduct ncbigene:481271 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
PDPK1 GeneProduct ncbigene:479875 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
VAV2 GeneProduct ncbigene:608060 VAV2; vav 2 oncogene
VAV3 GeneProduct ncbigene:479921 VAV3; vav 3 oncogene
ROCK2 GeneProduct ncbigene:482970 ROCK2; Rho-associated coiled-coil containing protein kinase
ROCK1 GeneProduct ncbigene:480181 ROCK1; Rho-associated coiled-coil containing protein kinase
SOS1 GeneProduct ncbigene:483042 SOS1; son of sevenless homolog 1 (Drosophila)
GIT2 GeneProduct ncbigene:477520 GIT2; G protein-coupled receptor kinase-interactor 2
PIK3R2 GeneProduct ncbigene:609956 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
ZYX GeneProduct ncbigene:482736 ZYX; zyxin
CAV1 GeneProduct ncbigene:403980 CAV1; caveolin 1 caveolae protein 22kD
CAV2 GeneProduct ncbigene:475294 CAV2; caveolin 2
CAV3 GeneProduct ncbigene:484671 CAV3; caveolin 3
FYN GeneProduct ncbigene:475032 FYN; FYN oncogene related to SRC FGR YES [EC:]
GRB2 GeneProduct ncbigene:483312 GRB2; growth factor receptor-bound protein 2
SEPP1 GeneProduct ncbigene:479346 SEPP1; selenoprotein P plasma
PTK2 GeneProduct ncbigene:475108 PTK2; PTK2 protein tyrosine kinase 2 [EC:
PTK2 GeneProduct ncbigene:475108 PTK2; PTK2 protein tyrosine kinase 2 [EC:
RHO GeneProduct ncbigene:493763 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
CSK GeneProduct ncbigene:487649 CSK; c-src tyrosine kinase [EC:]
BCAR1 GeneProduct ncbigene:479648 BCAR1; breast cancer anti-estrogen resistance 1
SRC GeneProduct ncbigene:485864 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
AKT1 GeneProduct ncbigene:490878 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2 GeneProduct ncbigene:449021 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
CAPN2 GeneProduct ncbigene:480118 CAPN2; calpain 2 (m/II) large subunit [EC:]
CAPN3 GeneProduct ncbigene:487518 CAPN3; calpain 3 (p94) [EC:]
CAPN5 GeneProduct ncbigene:485175 CAPN5; calpain
CAPN7 GeneProduct ncbigene:477062 CAPN7; calpain 7 [EC:
CAPN9 GeneProduct ncbigene:608044 CAPN9; calpain 9 (nCL-4) [EC:
CAPN10 GeneProduct ncbigene:607311 CAPN10; calpain 10 [EC:
CAPN11 GeneProduct ncbigene:609624 CAPN11; calpain 11 [EC:]
CAPN6 GeneProduct ncbigene:492068 CAPN6; calpain 6 [EC:]
PAK2 GeneProduct ncbigene:612814 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3 GeneProduct ncbigene:492067 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4 GeneProduct ncbigene:484513 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6 GeneProduct ncbigene:487490 PAK6; p21(CDKN1A)-activated kinase
TLN1 GeneProduct ncbigene:474759 TLN1; talin 1
MAP2K3 GeneProduct ncbigene:489547 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K6 GeneProduct ncbigene:480454 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK12 GeneProduct ncbigene:607023 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
AKT3 GeneProduct ncbigene:442964 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
DOCK1 GeneProduct ncbigene:486934 DOCK1; dedicator of cyto-kinesis
RAPGEF1 GeneProduct ncbigene:491286 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RAP1A GeneProduct ncbigene:483225 RAP1A; RAP1A member of RAS oncogene family
RAP1B GeneProduct ncbigene:608981 RAP1B; RAP1B member of RAS oncogene family
MAPK1 GeneProduct ncbigene:477575 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK6 GeneProduct ncbigene:478311 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAP2K1 GeneProduct ncbigene:478347 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2 GeneProduct ncbigene:611939 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
CAPN1 GeneProduct ncbigene:483745 CAPN1; calpain 1 (mu/I) large subunit [EC:]
ITGA2 GeneProduct ncbigene:489208
ITGA4 GeneProduct ncbigene:488429
ITGA5 GeneProduct ncbigene:486493
ITGA6 GeneProduct ncbigene:478800
ITGA8 GeneProduct ncbigene:487119
ITGA9 GeneProduct ncbigene:477021
ITGA10 GeneProduct ncbigene:608287
ITGA11 GeneProduct ncbigene:478353
ITGA2B GeneProduct ncbigene:403789
ITGAE GeneProduct ncbigene:480659
ITGAD GeneProduct ncbigene:607096
ITGAL GeneProduct ncbigene:489905
ITGAM GeneProduct ncbigene:489928
ITGAV GeneProduct ncbigene:488437
ITGAX GeneProduct ncbigene:489929
ITGB1 GeneProduct ncbigene:477956
ITGB2 GeneProduct ncbigene:403770
ITGB3 GeneProduct ncbigene:403788
ITGB4 GeneProduct ncbigene:483318
ITGB5 GeneProduct ncbigene:608977
ITGB6 GeneProduct ncbigene:488368
ITGB7 GeneProduct ncbigene:477598
ITGB8 GeneProduct ncbigene:475253
SRC GeneProduct ncbigene:485864 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
TNS1 GeneProduct ncbigene:488519 TNS; tensi
MAPK10 GeneProduct ncbigene:478464
PXN GeneProduct ncbigene:486299 PXN; paxillin
ILK GeneProduct ncbigene:476836 ILK; integrin-linked kinase [EC:2.7.1.-]
PAK1 GeneProduct ncbigene:607885 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
VASP GeneProduct ncbigene:403936 VASP; vasodilator-stimulated phosphoprotein
ITGA7 GeneProduct ncbigene:481097
ITGA1 GeneProduct ncbigene:489210


  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia