Heme biosynthesis (WP1086)

Canis familiaris

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The enzymatic process that produces heme is porphyrin synthesis. The process is highly conserved across biology. In humans, this pathway serves almost exclusively to form heme. Heme biosynthesis starts with the synthesis of D-Aminolevulinic acid (dALA or δALA) from the amino acid glycine and succinyl-CoA, which is produced in the TCA cycle (Krebs cycle). This reaction is catalyzed by ALA synthase, which is a rate-limiting enzyme that is regulated by intracellular glucose and heme levels. The major organs for heme synthesis are the liver and the bone marrow. Source: Adapted from Wikipedia.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Caroline Miller , Jonathan Mélius , Martina Summer-Kutmon , Eric Weitz , Egon Willighagen , and Kristina Hanspers

Activity

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Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

heme biosynthetic pathway

Participants

Label Type Compact URI Comment
O₂ Metabolite hmdb:HMDB0001377
NH3 Metabolite hmdb:HMDB0000051
H₂O₂ Metabolite hmdb:HMDB0003125
CoA Metabolite hmdb:HMDB0001423
CO₂ Metabolite hmdb:HMDB0001967
H₂O Metabolite hmdb:HMDB0002111
Porphobilinogen Metabolite hmdb:HMDB0000245
ALAS2 GeneProduct ncbigene:491498
FECH GeneProduct ncbigene:610360
PPOX GeneProduct ncbigene:478980
HMBS GeneProduct ncbigene:489373
ALAS1 GeneProduct ncbigene:476600
ALAD GeneProduct ncbigene:474808
UROS GeneProduct ncbigene:492116
UROD GeneProduct ncbigene:475378

References