G1 to S cell cycle control (WP1078)

Bos taurus

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Authors

Kristina Hanspers , Christine Chichester , and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

cell cycle checkpoint pathway G1/S DNA damage checkpoint pathway

Participants

Label Type Compact URI Comment
RB1 GeneProduct ensembl:ENSBTAG00000006640 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5925
E2F2 GeneProduct ensembl:ENSBTAG00000014400 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1870
E2F1 GeneProduct ensembl:ENSBTAG00000003971 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1869
POLE GeneProduct ensembl:ENSBTAG00000000590 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5426
CDKN1B GeneProduct ensembl:ENSBTAG00000018254 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1027
CDK6 GeneProduct ensembl:ENSBTAG00000044023 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1021
PCNA GeneProduct ensembl:ENSBTAG00000006065 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5111
CDK4 GeneProduct ensembl:ENSBTAG00000046091 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1019
CDKN1A GeneProduct ensembl:ENSBTAG00000008353 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1026
CDC45 GeneProduct ensembl:ENSBTAG00000004286 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8318
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1029
CDK1 GeneProduct ensembl:ENSBTAG00000010109 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:983
TP53 GeneProduct ensembl:ENSBTAG00000001069 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7157
PRIM2 GeneProduct ensembl:ENSBTAG00000007937 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5558
CDKN1C GeneProduct ensembl:ENSBTAG00000031184 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1028
CCND2 GeneProduct ensembl:ENSBTAG00000016649 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:894
E2F5 GeneProduct ensembl:ENSBTAG00000009378 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1875
CCNE1 GeneProduct ensembl:ENSBTAG00000004735 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:898
CREB3L4 GeneProduct ensembl:ENSBTAG00000014692 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:148327
CDKN2B GeneProduct ensembl:ENSBTAG00000016412 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1030
MDM2 GeneProduct ensembl:ENSBTAG00000010422 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4193
CDK7 GeneProduct ensembl:ENSBTAG00000011046 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1022
CCNG2 GeneProduct ensembl:ENSBTAG00000021768 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:901
RPA2 GeneProduct ensembl:ENSBTAG00000006225 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6118
CDK2 GeneProduct ensembl:ENSBTAG00000004021 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1017
E2F4 GeneProduct ensembl:ENSBTAG00000012063 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1874
CDKN2D GeneProduct ensembl:ENSBTAG00000010731 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1032
CREB3 GeneProduct ensembl:ENSBTAG00000011429 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10488
CREB3L3 GeneProduct ensembl:ENSBTAG00000010215 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:84699
MYT1 GeneProduct ensembl:ENSBTAG00000006352 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4661
TFDP2 GeneProduct ensembl:ENSBTAG00000006222 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7029
CCNB1 GeneProduct ensembl:ENSBTAG00000014239 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:891
CCND3 GeneProduct ensembl:ENSBTAG00000010106 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:896
CCND1 GeneProduct ensembl:ENSBTAG00000017514 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:595
CCNH GeneProduct ensembl:ENSBTAG00000011650 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:902
MYC GeneProduct ensembl:ENSBTAG00000008409 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4609
RPA3 GeneProduct ensembl:ENSBTAG00000013168 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6119
MCM4 GeneProduct ensembl:ENSBTAG00000046325 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4173
MCM3 GeneProduct ensembl:ENSBTAG00000010721 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4172
ATF6B GeneProduct ensembl:ENSBTAG00000008794 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1388
ORC1 GeneProduct ensembl:ENSBTAG00000002719 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4998
MCM6 GeneProduct ensembl:ENSBTAG00000015172 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4175
MCM7 GeneProduct ensembl:ENSBTAG00000030965 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4176
MCM2 GeneProduct ensembl:ENSBTAG00000014380 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4171
ORC3 GeneProduct ensembl:ENSBTAG00000016969 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23595
CDKN2C GeneProduct ensembl:ENSBTAG00000011059 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1031
POLE2 GeneProduct ensembl:ENSBTAG00000004931 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5427
MNAT1 GeneProduct ensembl:ENSBTAG00000030801 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4331
ORC6 GeneProduct ensembl:ENSBTAG00000001872 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23594
MCM5 GeneProduct ensembl:ENSBTAG00000015595 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4174
E2F6 GeneProduct ensembl:ENSBTAG00000048286 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1876
ORC2 GeneProduct ensembl:ENSBTAG00000031473 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4999
E2F3 GeneProduct ensembl:ENSBTAG00000021045 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1871
TFDP1 GeneProduct ensembl:ENSBTAG00000019645 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7027
RPA1 GeneProduct ensembl:ENSBTAG00000009711 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6117
CREB1 GeneProduct ensembl:ENSBTAG00000005474 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1385
RBL1 GeneProduct ensembl:ENSBTAG00000011541 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5933
WEE1 GeneProduct ensembl:ENSBTAG00000005278 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7465
ATM GeneProduct ensembl:ENSBTAG00000003111 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:472
CREB3L1 GeneProduct ensembl:ENSBTAG00000006143 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:90993
GADD45A GeneProduct ensembl:ENSBTAG00000013860 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1647
POLA2 GeneProduct ensembl:ENSBTAG00000011455 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23649
ORC4 GeneProduct ensembl:ENSBTAG00000015291 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5000
PRIM1 GeneProduct ensembl:ENSBTAG00000044000 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5557
CDC25A GeneProduct ensembl:ENSBTAG00000009586 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:993
CCNA1 GeneProduct ensembl:ENSBTAG00000007284 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8900
ORC5 GeneProduct ensembl:ENSBTAG00000040058 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5001
CCNE2 GeneProduct ensembl:ENSBTAG00000004906 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9134

References

  1. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia