mRNA Processing (WP1023)

Bos taurus

This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated. 5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds. 3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion. Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule. Description adapted from Wikipedia: http://en.wikipedia.org/wiki/Post-transcriptional_modification Pathway adapted from http://www.reactome.org.

Authors

Kristina Hanspers , Daniela Digles , and Martina Summer-Kutmon

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

transcription pathway spliceosome pathway

Participants

Label Type Compact URI Comment
GMP Metabolite cas:85-32-5
ATP Metabolite cas:1927-31-7
PRPF4 GeneProduct ensembl:ENSBTAG00000004571 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9128
SNRPA1 GeneProduct ensembl:ENSBTAG00000013593 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6627
RBM17 GeneProduct ensembl:ENSBTAG00000021951 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:84991
SNRPD3 GeneProduct ensembl:ENSBTAG00000021262 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6634
NCBP2 GeneProduct ensembl:ENSBTAG00000008873 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:22916
RNGTT GeneProduct ensembl:ENSBTAG00000002725 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8732
SNRPD1 GeneProduct ensembl:ENSBTAG00000012376 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6632
SF3A2 GeneProduct ensembl:ENSBTAG00000025452 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8175
SNRPD2 GeneProduct ensembl:ENSBTAG00000012177 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6633
XRN2 GeneProduct ensembl:ENSBTAG00000011304 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:22803
DHX16 GeneProduct ensembl:ENSBTAG00000006960 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8449
HNRPM GeneProduct ensembl:ENSBTAG00000039263 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4670
HNRNPA1 GeneProduct ensembl:ENSBTAG00000001553 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3178
CELF2 GeneProduct ensembl:ENSBTAG00000008937 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10659
SPOP GeneProduct ensembl:ENSBTAG00000005824 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8405
HNRNPA2B1 GeneProduct ensembl:ENSBTAG00000005726 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3181
PHF5A GeneProduct ensembl:ENSBTAG00000006423 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:84844
SF3B5 GeneProduct ensembl:ENSBTAG00000009795 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:83443
HNRNPR GeneProduct ensembl:ENSBTAG00000016578 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10236
PRPF6 GeneProduct ensembl:ENSBTAG00000011656 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:24148
YBX1 GeneProduct ensembl:ENSBTAG00000017368 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4904
SFRS9 GeneProduct ensembl:ENSBTAG00000012792 PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing)
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8683
SUGP1 GeneProduct ensembl:ENSBTAG00000006116 inferred from: SURP 2, G patch protein, UniProt:O60378
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57794
SNU13 GeneProduct ensembl:ENSBTAG00000006104 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4809
SF3B3 GeneProduct ensembl:ENSBTAG00000010627 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23450
PRPF40A GeneProduct ensembl:ENSBTAG00000048151 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55660
PSKH1 GeneProduct ensembl:ENSBTAG00000018037 PMID: 12466556
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5681
SNRPB2 GeneProduct ensembl:ENSBTAG00000027506 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6629
HNRPH2 GeneProduct ensembl:ENSBTAG00000007499 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3188
SNRNP40 GeneProduct ensembl:ENSBTAG00000016817 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9410
HNRNPU GeneProduct ensembl:ENSBTAG00000007606 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3192
LSM7 GeneProduct ensembl:ENSBTAG00000004521 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51690
DDX1 GeneProduct ensembl:ENSBTAG00000009906 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1653
SRPK1 GeneProduct ensembl:ENSBTAG00000016838 PMID: 12773558
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6732
U2AF1 GeneProduct ensembl:ENSBTAG00000011645 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7307
TRA2B GeneProduct ensembl:ENSBTAG00000001697 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6434
SRPK2 GeneProduct ensembl:ENSBTAG00000002175 PMID: 12773558
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6733
SNU13 GeneProduct ensembl:ENSBTAG00000006104 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4809
SUPT5H GeneProduct ensembl:ENSBTAG00000010467 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6829
SRP54 GeneProduct ensembl:ENSBTAG00000019085 PMID: 14729963
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6729
PRPF4B GeneProduct ensembl:ENSBTAG00000002086 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8899
CELF1 GeneProduct ensembl:ENSBTAG00000002520 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10658
SRSF1 GeneProduct ensembl:ENSBTAG00000014766 Antagonist splicing factor
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6426
CLP1 GeneProduct ensembl:ENSBTAG00000006493 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10978
SNRPF GeneProduct ensembl:ENSBTAG00000016271 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6636
METTL3 GeneProduct ensembl:ENSBTAG00000015148 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:56339
SRSF6 GeneProduct ensembl:ENSBTAG00000008527 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6431
NXF1 GeneProduct ensembl:ENSBTAG00000009488 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10482
SF3B2 GeneProduct ensembl:ENSBTAG00000002778 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10992
SFPQ GeneProduct ensembl:ENSBTAG00000016328 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6421
RBM5 GeneProduct ensembl:ENSBTAG00000006330 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10181
PRPF3 GeneProduct ensembl:ENSBTAG00000013946 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9129
SNU13 GeneProduct ensembl:ENSBTAG00000006104 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4809
CSTF3 GeneProduct ensembl:ENSBTAG00000008617 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1479
PAPOLA GeneProduct ensembl:ENSBTAG00000004054 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10914
HNRPD GeneProduct ensembl:ENSBTAG00000013952 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3184
CPSF3 GeneProduct ensembl:ENSBTAG00000019735 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51692
HNRNPAB GeneProduct ensembl:ENSBTAG00000013627 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3182
CLASRP GeneProduct ensembl:ENSBTAG00000013697 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11129
DICER1 GeneProduct ensembl:ENSBTAG00000012852 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23405
PABPN1 GeneProduct ensembl:ENSBTAG00000006884 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8106
U2 GeneProduct ensembl:ENSBTAG00000046891 GenBank sequence: K00027
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6066
HRMT1L2 GeneProduct ensembl:ENSBTAG00000006646 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3276
CPSF4 GeneProduct ensembl:ENSBTAG00000002090 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10898
SFSWAP GeneProduct ensembl:ENSBTAG00000000439 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6433
SRSF3 GeneProduct ensembl:ENSBTAG00000040006 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6428
SF3A1 GeneProduct ensembl:ENSBTAG00000003390 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10291
CD2BP2 GeneProduct ensembl:ENSBTAG00000015486 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10421
LSM2 GeneProduct ensembl:ENSBTAG00000005634 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57819
TMED10 GeneProduct ensembl:ENSBTAG00000005694 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10972
CPSF2 GeneProduct ensembl:ENSBTAG00000010227 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:53981
CPSF1 GeneProduct ensembl:ENSBTAG00000008355 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:29894
SRSF2 GeneProduct ensembl:ENSBTAG00000018258 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6427
PPM1G GeneProduct ensembl:ENSBTAG00000019522 PMID: 12773558
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5496
NUDT21 GeneProduct ensembl:ENSBTAG00000010207 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11051
SF3B4 GeneProduct ensembl:ENSBTAG00000026365 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10262
CSTF2 GeneProduct ensembl:ENSBTAG00000003547 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1478
HNRPC GeneProduct ensembl:ENSBTAG00000011396 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3183
SFRS12 GeneProduct ensembl:ENSBTAG00000007321 PMID: 14559993. SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection.
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:140890
SRSF4 GeneProduct ensembl:ENSBTAG00000013309 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6429
CLK2 GeneProduct ensembl:ENSBTAG00000014393 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1196
PRPF8 GeneProduct ensembl:ENSBTAG00000011488 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10594
SF3A3 GeneProduct ensembl:ENSBTAG00000007299 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10946
SNRPN GeneProduct ensembl:ENSBTAG00000008251 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6638
CLK4 GeneProduct ensembl:ENSBTAG00000019414 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57396
SF3B1 GeneProduct ensembl:ENSBTAG00000008915 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23451
PRPF4 GeneProduct ensembl:ENSBTAG00000004571 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9128
PRMT2 GeneProduct ensembl:ENSBTAG00000005503 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3275
DDX20 GeneProduct ensembl:ENSBTAG00000018717 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11218
NONO GeneProduct ensembl:ENSBTAG00000012152 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4841
CELF4 GeneProduct ensembl:ENSBTAG00000004940 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:56853
SFRS5 GeneProduct ensembl:ENSBTAG00000011596 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6430
PRPF18 GeneProduct ensembl:ENSBTAG00000017244 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8559
CSTF2T GeneProduct ensembl:ENSBTAG00000018406 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23283
PTBP1 GeneProduct ensembl:ENSBTAG00000045828 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5725
SNRPN GeneProduct ensembl:ENSBTAG00000008251 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6638
CSTF1 GeneProduct ensembl:ENSBTAG00000006639 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1477
HNRNPL GeneProduct ensembl:ENSBTAG00000001055 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3191
U2AF2 GeneProduct ensembl:ENSBTAG00000002830 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11338
SRSF7 GeneProduct ensembl:ENSBTAG00000014891 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6432
DHX9 GeneProduct ensembl:ENSBTAG00000019821 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1660
SUGP2 GeneProduct ensembl:ENSBTAG00000013288 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10147
SRRM1 GeneProduct ensembl:ENSBTAG00000013772 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10250
RNMT GeneProduct ensembl:ENSBTAG00000009142 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8731
SNRPE GeneProduct ensembl:ENSBTAG00000039066 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6635
CDC40 GeneProduct ensembl:ENSBTAG00000000409 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51362
SNRPB GeneProduct ensembl:ENSBTAG00000001038 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6628
SMC1A GeneProduct ensembl:ENSBTAG00000017761 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8243
SNRNP70 GeneProduct ensembl:ENSBTAG00000001996 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6625
PRPF8 GeneProduct ensembl:ENSBTAG00000011488 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10594
TXNL4A GeneProduct ensembl:ENSBTAG00000013587 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10907
NCBP1 GeneProduct ensembl:ENSBTAG00000009732 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4686
CDC40 GeneProduct ensembl:ENSBTAG00000000409 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51362
DHX8 GeneProduct ensembl:ENSBTAG00000008339 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1659
CLK1 GeneProduct ensembl:ENSBTAG00000005408 PMID: 15010457: Inhibitor John C. Bell, PhD Professor, Depts. of Medicine and Biochemistry, Microbiology & Immunology University of Ottawa Career Scientist, Ottawa Regional Cancer Centre Associate Scientist, The Ottawa Hospital Research Institute Telephone: 613-737-7700 ext 6893 Fax: 613-247-3524 Email: [email protected] The control of pre-mRNA splicing by the Clk kinase family We are studying a family of kinases which we believe provide an interface between intracellular signaling networks and the post-transcriptional mechanism of mRNA splicing. We are performing a structure:function analysis of the three Clk family members to identify domains in the three proteins which are involved in regulating splicing. Using homologous recombination we are generating null strains of mice which are lacking one, two or all three Clk genes. The Clk kinases all possess dual specificity kinase activity and yeast expression systems are being used to produce large amounts of the kinase to perform a detailed analysis of the sites of serine, threonine and tyrosine autophosphorylation within the kinase.
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1195
CLK3 GeneProduct ensembl:ENSBTAG00000007304 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1198
PTBP2 GeneProduct ensembl:ENSBTAG00000008809 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:58155
EFTUD2 GeneProduct ensembl:ENSBTAG00000013526 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9343
LSM2 GeneProduct ensembl:ENSBTAG00000005634 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57819
RBM39 GeneProduct ensembl:ENSBTAG00000003949 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9584
SNRPA GeneProduct ensembl:ENSBTAG00000009077 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6626
HNRNPH1 GeneProduct ensembl:ENSBTAG00000009389 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3187
FUS GeneProduct ensembl:ENSBTAG00000005757 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2521
RNPS1 GeneProduct ensembl:ENSBTAG00000046336 PMID: 14729963
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10921
DHX15 GeneProduct ensembl:ENSBTAG00000008896 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1665

References

  1. mRNA nuclear export at a glance. Carmody SR, Wente SR. J Cell Sci. 2009 Jun 15;122(Pt 12):1933–7. PubMed Europe PMC Scholia