Type II interferon signaling (IFNG) (WP1017)

Bos taurus

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Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Authors

Martina Summer-Kutmon

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

type II interferon signaling pathway Jak-Stat signaling pathway

Participants

Label Type Compact URI Comment
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IFNGR1 GeneProduct ensembl:ENSBTAG00000012544 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3459
IFNGR2 GeneProduct ensembl:ENSBTAG00000012899 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3460
JAK1 GeneProduct ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK2 GeneProduct ensembl:ENSBTAG00000012047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
JAK2 GeneProduct ensembl:ENSBTAG00000012047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
IFNGR2 GeneProduct ensembl:ENSBTAG00000012899 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3460
IFNGR1 GeneProduct ensembl:ENSBTAG00000012544 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3459
JAK1 GeneProduct ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
JAK2 GeneProduct ensembl:ENSBTAG00000012047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
IFNGR2 GeneProduct ensembl:ENSBTAG00000012899 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3460
IFNGR1 GeneProduct ensembl:ENSBTAG00000012544 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3459
JAK1 GeneProduct ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
IFNGR2 GeneProduct ensembl:ENSBTAG00000012899 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3460
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
JAK1 GeneProduct ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK2 GeneProduct ensembl:ENSBTAG00000012047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
IFNGR1 GeneProduct ensembl:ENSBTAG00000012544 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3459
SOCS3 GeneProduct ensembl:ENSBTAG00000008441 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9021
SOCS1 GeneProduct ensembl:ENSBTAG00000004386 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651
PTPN11 GeneProduct ensembl:ENSBTAG00000002048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT2 GeneProduct ensembl:ENSBTAG00000004380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773
STAT2 GeneProduct ensembl:ENSBTAG00000004380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT2 GeneProduct ensembl:ENSBTAG00000004380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
PRKCD GeneProduct ensembl:ENSBTAG00000008719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
IRF4 GeneProduct ensembl:ENSBTAG00000002929 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3662
SPI1 GeneProduct ensembl:ENSBTAG00000021709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6688
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT2 GeneProduct ensembl:ENSBTAG00000004380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
INFAF GeneProduct ensembl:ENSBTAG00000046824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3440
IL6 GeneProduct ensembl:ENSBTAG00000046456 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456
HLA-B GeneProduct ensembl:ENSBTAG00000038619 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3106
INOS GeneProduct ensembl:ENSBTAG00000006894 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4843
GBP1 GeneProduct ensembl:ENSBTAG00000001143 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2633
PSMB9 GeneProduct ensembl:ENSBTAG00000008954 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5698
TAP1 GeneProduct ensembl:ENSBTAG00000008953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6890
OAS1Y GeneProduct ensembl:ENSBTAG00000039861 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4938
CXCL10 GeneProduct ensembl:ENSBTAG00000001725 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3627
CIITA GeneProduct ensembl:ENSBTAG00000020649 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4261
CYBB GeneProduct ensembl:ENSBTAG00000019953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1536
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IFIT2 GeneProduct ensembl:ENSBTAG00000034918 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3433
EIF2AK2 GeneProduct ensembl:ENSBTAG00000008703 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5610
IFI6 GeneProduct ensembl:ENSBTAG00000007554 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2537
IRF1 GeneProduct ensembl:ENSBTAG00000031231 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3659
ICAM1 GeneProduct ensembl:ENSBTAG00000010303 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3383
CXCL9 GeneProduct ensembl:ENSBTAG00000038639 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4283
ISG15 GeneProduct ensembl:ENSBTAG00000014707 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9636
IRF8 GeneProduct ensembl:ENSBTAG00000017824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3394
IRF8 GeneProduct ensembl:ENSBTAG00000017824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3394
IRF2 GeneProduct ensembl:ENSBTAG00000010002 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3660

References

  1. A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia