Delta-Notch Signaling Pathway (Gallus gallus)

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ICDMolecular associationAutophosphorylationExtracellularProteolytic CleavageDCY->NUControlNUPM->NUCY->NUDDMethylationGOICDDemethylation-- ICDMitochondrionERUbiquitinationGO->PMGene SymbolCY->NULigandPMMolecule in the pathwayCY->NUReactioin through unknown mechanisms/moleculesICDPM->NUDeacetylationDephosphorylationEnzyme complexEndoplasmic reticulumAccession Number: NetPath 3; cellmap:3DesumoylationGamma secretase complexPalmitoylationPlasma membraneProteins in a complex interactionGlycosylationICDCytoplasmDRecruitmentNucleusGolgi apparatusTranslocationDDeubiquitinationInhibitionSumoylationPM->NUNU->CYCYActivationNU->CYDICDPM->CYGO->PMICD(Protein-protein interaction)MTPM->NUEndosomeAcetylationNU->CYReceptorECCY->NUPhosphorylationENIntracellular DomainJAG2NFKBIAZFPM1DLL1MAML1PIK3R2ADAM10HDAC1MAPK3TCF3NOVAKT1JUNDTX1SNW1SKP2HES6HES5PSEN1NOTCH2LEF1EGFRPSEN2SMAD4NOTCH1MAML2TLE1CNTFNOTCH4RBPJGSK3BSIN3AJAG1LFNGDLL1JAG1NOTCH1CNTFRNOTCH1FHL1ADAM17JAG2NOTCH2MAML3NOTCH3NUMBLHEY2HEY1APH1ANOTCH3HIVEP3NOTCH2ITCHNCOR1LCKDTX1RELAPSENENAPPNOTCH4MAPK1ASCL1RCJMB04_1i20FBXW7MFNGFURINSKP1AJAK2NOTCH1RELASTAT3GSK3BNCSTNPOFUT1WDR12DLL4PIK3R1NOTCH1SAP30CNTN1CDK2EP300PCAFNCOR1EP300NOTCH1DLL4RING1SPENRBX1SKP1AHES1JAG1JAG2EGFRCJMB04_31l21NCOR2SMAD3CUL1HDAC2MAGEA1TP53DLL1NOTCH2NOTCH3APH1BSTAT3SMAD1MEF2CSKP2NUMBNCOR2


Description

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Comments

GenMAPP notes 
NetPath 3; cellmap:3 - Delta-Notch Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP61(r20805) with a 75% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
68868view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67152view10:13, 26 June 2013Christine ChichesterOntology Term : 'Notch signaling pathway' added !
41007view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35711view23:19, 12 February 2010AlexanderPico
33928view18:10, 9 December 2009MaintBotAutomatic update of empty xrefs
31544view21:50, 13 August 2009MaintBotFixed text labels
30396view21:08, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProduct374113 (Entrez Gene)
ADAM17GeneProduct421931 (Entrez Gene)
AKT1GeneProduct395928 (Entrez Gene)
APH1AGeneProduct769986 (Entrez Gene)
APH1BGeneProduct
APPGeneProduct374198 (Entrez Gene)
ASCL1GeneProduct386573 (Entrez Gene)
CDK2GeneProduct
CNTFGeneProduct396488 (Entrez Gene)
CNTFRGeneProduct395885 (Entrez Gene)
CNTN1GeneProduct417786 (Entrez Gene)
CUL1GeneProduct420783 (Entrez Gene)
DLL1GeneProduct395820 (Entrez Gene)
DLL4GeneProduct423208 (Entrez Gene)
DTX1GeneProduct
EGFGeneProduct408035 (Entrez Gene)
EGFRGeneProduct396494 (Entrez Gene)
EP300GeneProduct418000 (Entrez Gene)
FBXW7GeneProduct422481 (Entrez Gene)
FHL1GeneProduct
FURINGeneProduct395457 (Entrez Gene)
GSK3BGeneProduct418335 (Entrez Gene)
HDAC1GeneProduct373961 (Entrez Gene)
HDAC2GeneProduct395635 (Entrez Gene)
HES1GeneProduct395128 (Entrez Gene)
HES5GeneProduct419392 (Entrez Gene)
HES6GeneProduct424829 (Entrez Gene)
HEY1GeneProduct428365 (Entrez Gene)
HEY2GeneProduct421718 (Entrez Gene)
HIVEP3GeneProduct428208 (Entrez Gene)
ITCHGeneProduct419145 (Entrez Gene)
JAG1GeneProduct396043 (Entrez Gene)
JAG2GeneProduct776138 (Entrez Gene)
JAK2GeneProduct374199 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
LCKGeneProduct
LEF1GeneProduct395865 (Entrez Gene)
LFNGGeneProduct395790 (Entrez Gene)
MAGEA1GeneProduct
MAML1GeneProduct416286 (Entrez Gene)
MAML2GeneProduct428088 (Entrez Gene)
MAML3GeneProduct422445 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MAPK3GeneProduct
MEF2CGeneProduct769007 (Entrez Gene)
MFNGGeneProduct418042 (Entrez Gene)
NCOR1GeneProduct417598 (Entrez Gene)
NCOR2GeneProduct416815 (Entrez Gene)
NCSTNGeneProduct426905 (Entrez Gene)
NFKBIAGeneProduct396093 (Entrez Gene)
NOTCH1GeneProduct395655 (Entrez Gene)
NOTCH2GeneProduct374031 (Entrez Gene)
NOTCH3GeneProduct
NOTCH4GeneProduct
NOVGeneProduct396204 (Entrez Gene)
NUMBGeneProduct395639 (Entrez Gene)
NUMBLGeneProduct
PCAFGeneProduct428441 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PIK3R2GeneProduct771142 (Entrez Gene)
POFUT1GeneProduct395070 (Entrez Gene)
PSEN1GeneProduct373977 (Entrez Gene)
PSEN2GeneProduct374188 (Entrez Gene)
PSENENGeneProduct
RBPJGeneProduct422802 (Entrez Gene)
RBX1GeneProduct418001 (Entrez Gene)
RCJMB04_1i20GeneProduct423455 (Entrez Gene)
RCJMB04_31l21GeneProduct426529 (Entrez Gene)
RELAGeneProduct
RING1GeneProduct
SAP30GeneProduct422562 (Entrez Gene)
SIN3AGeneProduct415307 (Entrez Gene)
SKP1AGeneProduct
SKP2GeneProduct427437 (Entrez Gene)
SMAD1GeneProduct395680 (Entrez Gene)
SMAD3GeneProduct395132 (Entrez Gene)
SMAD4GeneProduct
SNW1GeneProduct423381 (Entrez Gene)
SPENGeneProduct419460 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)
TCF3GeneProduct395146 (Entrez Gene)
TLE1GeneProduct427450 (Entrez Gene)
TP53GeneProduct396200 (Entrez Gene)
WDR12GeneProduct424089 (Entrez Gene)
ZFPM1GeneProduct415835 (Entrez Gene)

Annotated Interactions

No annotated interactions
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