Wnt Signaling Pathway and Pluripotency (Mus musculus)

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4Tcf/Lef-1NucleusUbiquitin Taggedbeta-cateninStabilized beta-cateninWnt ReceptorsTcf/Lef-1TR: Transcriptional RegulationBIOTR+pbeta-cateninPhosphorylated beta-cateninTcf/Lef-1PP2ACytoskeletonTR+pDifferentiationTRApoptosisRecruitment to UnknownUbiquitin Conjugating EnzymePromotes PluripotencyTRIQ1+pPluripotency26S Proteasome DegradationProtein Kinase Cbeta-cateninPromotes DifferentiationFrizzled Ligands31Wnt7bPrkczPpp2r2aWnt6Wnt1Wnt3Tcf2Ccnd1PrkccCtbp1Sox2Mapk10Wnt11Wnt4Fzd4Fzd2Nkd2Cd44Foxd3NlkPrkcqTcf4Zbtb33Map3k7Fzd9Fzd3Ep300Fzd1ApcWnt2Ppm1jJunTcf3Fzd5Fzd6Ppp2cbWnt3aPpp2r4Ccnd2Wnt10bWnt2bPpp2r1bRacgap1PrkcaFrat1Trp53Ppp2r5cPpp2r1aWnt7aLrp6Ctnnb1PrkchCtnnd1LdlrDvl3PrkciWnt9bDvl2Ppp2r2dFzd7Fosl1Lrp5Ppp2r5eFbxw2Axin1Pou5f1Tcf1Wnt10aPpardPrkceWnt16Wnt5bWnt5aCtbp2RhoaPpp2r2bAxin2NfyaCsnk1eGrouchoPrkcdCcnd3MycFzd8PlauPpp2caPrkd1Mapk9Mmp7Wnt11CrebbpPafah1b1Nkd1PrkcbGsk3bNanogLef1Dvl1Ppp2r2c


This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining

Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.

Quality Tags

Ontology Terms



  1. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  2. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  3. Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC Scholia
  4. ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html,


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107722view12:30, 31 October 2019DeSlConverted unconnected lines to graphical lines if needed.
107676view23:58, 25 October 2019AlexanderPicoReverted to version '03:34, 1 September 2016' by AlexanderPico
107673view22:42, 25 October 2019Lli9Added ASH2L plus reference.
89312view10:34, 1 September 2016Mkutmonfix Frat1 identifier
80030view12:27, 1 May 2015EgonwFixed the data source: the identifier is from Entrez Gene, not Ensembl.
69165view18:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
67758view11:59, 26 June 2013DdiglesOntology Term : 'canonical Wnt signaling pathway' added !
59063view21:01, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41353view00:26, 2 March 2011MaintBotRemoved redundant pathway information and comments
34411view23:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33425view14:53, 30 November 2009MaintBotRemoved group label
31484view21:27, 13 August 2009MaintBotFixed text labels
30063view17:58, 30 June 2009NsalomonisNew pathway

External references


View all...
NameTypeDatabase referenceComment
ApcGeneProduct11789 (Entrez Gene)
Axin1GeneProduct12005 (Entrez Gene)
Axin2GeneProduct12006 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Ccnd3GeneProduct12445 (Entrez Gene)
Cd44GeneProduct12505 (Entrez Gene)
CrebbpGeneProduct12914 (Entrez Gene)
Csnk1eGeneProduct27373 (Entrez Gene)
Ctbp1GeneProduct13016 (Entrez Gene)
Ctbp2GeneProduct13017 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Ctnnd1GeneProduct12388 (Entrez Gene)
Dvl1GeneProduct13542 (Entrez Gene)
Dvl2GeneProduct13543 (Entrez Gene)
Dvl3GeneProduct13544 (Entrez Gene)
Ep300GeneProduct328572 (Entrez Gene)
Fbxw2GeneProduct30050 (Entrez Gene)
Fosl1GeneProduct14283 (Entrez Gene)
Foxd3GeneProduct15221 (Entrez Gene)
Frat1GeneProductENSMUSG00000067199 (Ensembl)
Fzd1GeneProduct14362 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
Fzd3GeneProduct14365 (Entrez Gene)
Fzd4GeneProduct14366 (Entrez Gene)
Fzd5GeneProduct14367 (Entrez Gene)
Fzd6GeneProduct14368 (Entrez Gene)
Fzd7GeneProduct14369 (Entrez Gene)
Fzd8GeneProduct14370 (Entrez Gene)
Fzd9GeneProduct14371 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
LdlrGeneProduct16835 (Entrez Gene)
Lef1GeneProduct16842 (Entrez Gene)
Lrp5GeneProduct16973 (Entrez Gene)
Lrp6GeneProduct16974 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Mapk10GeneProduct26414 (Entrez Gene)
Mapk9GeneProduct26420 (Entrez Gene)
Mmp7GeneProduct17393 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
NanogGeneProduct71950 (Entrez Gene)
NfyaGeneProduct18044 (Entrez Gene)
Nkd1GeneProduct93960 (Entrez Gene)
Nkd2GeneProduct72293 (Entrez Gene)
NlkGeneProduct18099 (Entrez Gene)
Pafah1b1GeneProduct18472 (Entrez Gene)
PlauGeneProduct18792 (Entrez Gene)
Pou5f1GeneProduct18999 (Entrez Gene)
PpardGeneProduct19015 (Entrez Gene)
Ppm1jGeneProduct71887 (Entrez Gene)
Ppp2caGeneProduct19052 (Entrez Gene)
Ppp2cbGeneProduct19053 (Entrez Gene)
Ppp2r1aGeneProduct51792 (Entrez Gene)
Ppp2r1bGeneProduct73699 (Entrez Gene)
Ppp2r2aGeneProduct71978 (Entrez Gene)
Ppp2r2bGeneProduct72930 (Entrez Gene)
Ppp2r2cGeneProduct269643 (Entrez Gene)
Ppp2r2dGeneProduct52432 (Entrez Gene)
Ppp2r4GeneProduct110854 (Entrez Gene)
Ppp2r5cGeneProduct26931 (Entrez Gene)
Ppp2r5eGeneProduct26932 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
PrkccGeneProduct18752 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
PrkceGeneProduct18754 (Entrez Gene)
PrkchGeneProduct18755 (Entrez Gene)
PrkciGeneProduct18759 (Entrez Gene)
PrkcqGeneProduct18761 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
Prkd1GeneProduct18760 (Entrez Gene)
Racgap1GeneProduct26934 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Sox2GeneProduct20674 (Entrez Gene)
Tcf1GeneProduct21405 (Entrez Gene)
Tcf2GeneProduct21410 (Entrez Gene)
Tcf3GeneProduct21415 (Entrez Gene)
Tcf4GeneProduct21413 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Wnt10aGeneProduct22409 (Entrez Gene)
Wnt10bGeneProduct22410 (Entrez Gene)
Wnt11GeneProduct22411 (Entrez Gene) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
Wnt1GeneProduct22408 (Entrez Gene)
Wnt16GeneProduct93735 (Entrez Gene)
Wnt2GeneProduct22413 (Entrez Gene)
Wnt2bGeneProduct22414 (Entrez Gene)
Wnt3GeneProduct22415 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
Wnt4GeneProduct22417 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
Wnt5bGeneProduct22419 (Entrez Gene)
Wnt6GeneProduct22420 (Entrez Gene)
Wnt7aGeneProduct22421 (Entrez Gene)
Wnt7bGeneProduct22422 (Entrez Gene)
Wnt9bGeneProduct22412 (Entrez Gene)
Zbtb33GeneProduct56805 (Entrez Gene)

Annotated Interactions

No annotated interactions

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