DNA Damage Response (only ATM dependent) (Homo sapiens)

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555555555555Osxidative StressresistanceCytokine receptorUV radiation --> DNA damageFrizzled LigandsPMetabolitemitoch-ondriumDifferent PathwayCellRASPI3KBCRPhosphorylatedActivationExtra cellularspcaceCaption:Origin DNA damageresponseProliferationGene productChange in the Cell conditionMembraneInhibitionDNA damage sourceNucleusCellTCRTCF-1/LEFMetabolismExtra cellularspaceCCND3PIK3C2BApoptosis WNT3RAC2NFKB2PIK3CBJUNApoptosis CCNG2PPP2R5EABL1NRASFOSL1WNT11TGFBMYCWNT6WNT2BFOXO3WNT10AG6PCSCP2ERBB2DNA damage responsePLAUDVL3MAPK10CDKN1BAKT3WNT1AKT2TCF-3Apoptosis AKT1PPP2R5CWNT4INSRDVL1BCL2Apoptosis AKT1NFKB1SOS2PIK3R5BAXWNT10BPIK3R3WNT16CTNNB1BBC3APCWNT16BIKRBL2PIK3CGKRASFASLGBCL2L11CDKN1AWNT2Cell CycleWNT5AHRASMAPK9BAK1BBC3BADRAC1LEF1AKT2WNT3ACDC42DVL2SHC1WNT7ASOD2PIK3R1APCCCND1CATLDLRMAP3K1SMAD4TP73c-MycPIK3C3GSK3BPIK3C2ABCL2L11RAC3ATMMAPK8HMGB1SOS1RAC1CDKN2APIK3CDPTENTCF-1MAPK9SMAD3MLKLPDK1TGFB1RHOAMAPK2CCND2AXIN1PIK3C2GTP53PEPCKPMAIP1MAP3K4MAP3K7WNT5BPIK3R4Cell CycleTCF-4FRAT1BCL6GRB2AKT3PIK3CAWNT7BIRS1MDM2PIK3R2


Description

This is one of two pathways that deal with DNA damage. It has two central gene products (ATM and TP53) which are connected with the other DNA damage response pathway.

In this pathway there is only one source of DNA damage induction, since most DNA damage induction sources and their involvement are mentioned in the first DNA damage response pathway. If it is not mentioned differently, the processes take place in the cell cytoplasm.

The purpose of this second pathway is to report more gene products and cell condition changes through the DNA damage response pathway and at the same time keep them clearly arranged.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed Europe PMC
  2. Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed Europe PMC
  3. Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed Europe PMC
  4. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC
  5. Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed Europe PMC
  6. Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed Europe PMC
  7. Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed Europe PMC
  8. Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC
  9. Lأ¯آ؟آ½أ¯آ؟آ½أژآ©brich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC
  10. Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed Europe PMC
  11. Fan HY, O'Connor A, Shitanaka M, Shimada M, Liu Z, Richards JS; ''Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization.''; Mol Endocrinol, 2010 PubMed Europe PMC
  12. Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC
  13. Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed Europe PMC
  14. Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed Europe PMC
  15. Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed Europe PMC
  16. Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed Europe PMC
  17. Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed Europe PMC
  18. Chargari C, Toillon RA, Macdermed D, Castadot P, Magnأ¯آ؟آ½أ¯آ؟آ½أژآ© N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106372view00:55, 23 August 2019KhanspersModified description
105500view05:53, 8 August 2019KhanspersModified description
105238view20:32, 23 July 2019Khansperslayout changes and updated legend
104836view14:14, 20 June 2019Fehrhartinteraction between CTNNB1 and TCF complex
104835view14:12, 20 June 2019Fehrhart
104833view13:59, 20 June 2019Fehrhart
104309view21:41, 15 May 2019Khanspersupdated legend, clarified phosphorylation of CTNNB1, unified fonts, cleanup
104308view21:00, 15 May 2019KhanspersModified description
104307view20:59, 15 May 2019KhanspersModified description
95580view03:04, 3 January 2018Asios OliaModified description
94761view15:50, 5 October 2017Ryanmillerconnected lines
79974view08:10, 29 April 2015ZariChanged uniprot Id to Entrez gene for RAS, PI3K and TCF-1/LEF genes
70109view19:06, 12 July 2013MaintBotupdating to 2013 schema
69906view19:31, 11 July 2013AlexanderPicoModified title
67156view10:14, 26 June 2013Christine ChichesterOntology Term : 'p53-dependent G1/S DNA damage checkpoint pathway' added !
59215view20:07, 22 February 2013MaintBotUpdated Ensembl data source
46091view03:26, 15 December 2011AlexanderPicoconverted more hugo to hgnc
46084view02:18, 15 December 2011AllanKuchinskySpecify description
46083view02:17, 15 December 2011AllanKuchinskyupdated HGNC IDs
46082view02:12, 15 December 2011AllanKuchinskySpecify description
46081view19:32, 14 December 2011AlexanderPicoconverted a couple HUGOs to HGNC
45197view10:06, 7 October 2011MartijnVanIerselOntology Term : 'p53 signaling pathway' added !
41219view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38810view08:13, 24 September 2010Jildaucompartments
38809view08:10, 24 September 2010Jildautransparent
38808view08:01, 24 September 2010JildauReverted to version '13:13, 23 September 2010' by Jildau
38807view08:01, 24 September 2010JildauReverted to version '07:53, 24 September 2010' by Jildau
38806view07:56, 24 September 2010JildauReverted to version '13:13, 23 September 2010' by Jildau
38805view07:53, 24 September 2010Jildaucompartments
38658view13:13, 23 September 2010Mkutmonadded pathway links for "apoptosis", "dna damage response", "cell cycle"
33421view14:52, 30 November 2009MaintBotRemoved group label
30260view04:51, 25 July 2009AlexanderPicoModified categories
29695view07:30, 28 May 2009I379077Modified description
29688view13:25, 27 May 2009I379077Modified description
29679view13:05, 26 May 2009I379077Specify description
29678view12:53, 26 May 2009I379077Specify description
29677view12:49, 26 May 2009I379077Specify description
29676view12:14, 26 May 2009I379077Modified description
29665view09:28, 25 May 2009I379077Modified description
29664view09:21, 25 May 2009I379077Specify description
29663view08:48, 25 May 2009I379077Specify description
29662view08:46, 25 May 2009I379077Specify description
29554view07:39, 15 May 2009I379077Specify description
29546view14:45, 14 May 2009I379077Specify description
29544view11:28, 14 May 2009I379077Specify description
29543view09:46, 14 May 2009I379077Specify description
29539view14:51, 13 May 2009I379077Specify description
29532view10:57, 12 May 2009I379077Specify description
29530view09:17, 12 May 2009I379077Specify description
29529view08:40, 12 May 2009I379077Specify description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProductENSG00000097007 (Ensembl)
AKT1GeneProductAKT1 (HGNC)
AKT2GeneProductAKT2 (HGNC)
AKT3GeneProductAKT3 (HGNC)
APCGeneProduct324 (Entrez Gene)
APCGeneProductENSG00000134982 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
Apoptosis PathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductBBC3 (HGNC)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BCL6GeneProductENSG00000113916 (Ensembl)
BIKGeneProductENSG00000100290 (Ensembl)
CATGeneProductENSG00000121691 (Ensembl)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNG2GeneProductENSG00000138764 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CDKN2AGeneProductCDKN2A (HGNC)
CTNNB1GeneProduct1499 (Entrez Gene)
Cell CyclePathwayWP179 (WikiPathways)
DNA damage responsePathwayWP1530 (WikiPathways)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
ERBB2GeneProductENSG00000141736 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FOXO3GeneProductENSG00000118689 (Ensembl)
FRAT1GeneProduct10023 (Entrez Gene)
G6PCGeneProductENSG00000131482 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
HMGB1GeneProductENSG00000189403 (Ensembl)
HRASGeneProduct3265 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LDLRGeneProduct3949 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K4GeneProductENSG00000085511 (Ensembl)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK2GeneProduct5594 (Entrez Gene)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProduct5601 (Entrez Gene)
MAPK9GeneProductENSG00000050748 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MLKLGeneProductENSG00000168404 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NFKB1GeneProductNFKB1 (HGNC)
NFKB2GeneProductNFKB2 (HGNC)
NRASGeneProduct4893 (Entrez Gene)
PDK1GeneProductENSG00000152256 (Ensembl)
PEPCKGeneProduct5106 (Entrez Gene)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2BGeneProduct5287 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PIK3R5GeneProduct23533 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PPP2R5CGeneProduct5527 (Entrez Gene)
PPP2R5EGeneProduct5529 (Entrez Gene)
PTENGeneProductENSG00000171862 (Ensembl)
RAC1GeneProduct5879 (Entrez Gene)
RAC1GeneProductENSG00000136238 (Ensembl)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductRAC3 (HGNC)
RBL2GeneProductENSG00000103479 (Ensembl)
RHOAGeneProduct387 (Entrez Gene)
SCP2GeneProductENSG00000116171 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOD2GeneProductENSG00000112096 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCF-1GeneProduct6932 (Entrez Gene)
TCF-3GeneProduct83439 (Entrez Gene)
TCF-4GeneProduct6934 (Entrez Gene)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBGeneProduct7040 (Entrez Gene)
TP53GeneProductENSG00000141510 (Ensembl)
TP73GeneProductENSG00000078900 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
c-MycGeneProduct4609 (Entrez Gene)

Annotated Interactions

No annotated interactions

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