DNA Damage Response (only ATM dependent) (Homo sapiens)

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555555555555TCF-1/LEFDNA damage sourcePOsxidative StressresistanceProliferationBCRCytokine receptorFrizzled LigandsUV radiation --> DNA damageMetaboliteActivationmitoch-ondriumPhosphorylatedOrigin DNA damageresponseCellMetabolismCaption:NucleusPI3KMembraneDifferent PathwayInhibitionRASChange in the Cell conditionTCRExtra cellularspcaceCellExtra cellularspaceGene productPIK3C2AHMGB1BAK1WNT5AAPCPIK3R2AKT2WNT7APMAIP1MYCATMApoptosis CATMAP3K7PIK3C2GMAPK2PIK3C2BRAC1RAC1BCL2L11TP53WNT2BDVL3CCND2LDLRSCP2TGFBWNT10APIK3R1MAP3K1RHOALEF1WNT3FOXO3FOSL1NFKB2WNT7BDVL2Apoptosis TGFB1PDK1BCL2BAXFASLGPIK3CBRAC2PEPCKTCF-1PIK3CACTNNB1INSRPLAUCDKN1BMAPK9DNA damage responseERBB2SOS2AKT1DVL1c-MycWNT16SMAD4GRB2ABL1PIK3C3PTENG6PCMLKLTCF-3BCL2L11CDKN1AWNT1PPP2R5CAKT2Cell CycleWNT11MDM2CCND3WNT3AIRS1Apoptosis SHC1BBC3HRASAKT3SOD2PIK3R3JUNPIK3R4CDC42Apoptosis SOS1WNT2RAC3WNT16CCND1MAPK8KRASNRASAKT1WNT10BPPP2R5ERBL2BADTP73AKT3BCL6GSK3BPIK3R5FRAT1WNT5BMAPK9BBC3CDKN2AMAP3K4PIK3CDCell CycleWNT6AXIN1MAPK10APCNFKB1BIKCCNG2SMAD3PIK3CGTCF-4WNT4


This is one of two pathways that deal with DNA damage. It has two central gene products (ATM and TP53) which are connected with the other DNA damage response pathway.

In this pathway there is only one source of DNA damage induction, since most DNA damage induction sources and their involvement are mentioned in the first DNA damage response pathway. If it is not mentioned differently, the processes take place in the cell cytoplasm.

The purpose of this second pathway is to report more gene products and cell condition changes through the DNA damage response pathway and at the same time keep them clearly arranged.

Quality Tags

Ontology Terms



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  1. Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed
  2. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed
  3. Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed
  4. Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed
  5. Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed
  6. Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed
  7. Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed
  8. Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed
  9. Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed
  10. Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed
  11. Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed
  12. Lأ¯آ؟آ½أ¯آ؟آ½أژآ©brich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed
  13. Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed
  14. Chargari C, Toillon RA, Macdermed D, Castadot P, Magnأ¯آ؟آ½أ¯آ؟آ½أژآ© N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed
  15. Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed
  16. Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed
  17. Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed


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95580view03:04, 3 January 2018Asios OliaModified description
94761view15:50, 5 October 2017Ryanmillerconnected lines
79974view08:10, 29 April 2015ZariChanged uniprot Id to Entrez gene for RAS, PI3K and TCF-1/LEF genes
70109view19:06, 12 July 2013MaintBotupdating to 2013 schema
69906view19:31, 11 July 2013AlexanderPicoModified title
67156view10:14, 26 June 2013Christine ChichesterOntology Term : 'p53-dependent G1/S DNA damage checkpoint pathway' added !
59215view20:07, 22 February 2013MaintBotUpdated Ensembl data source
46091view03:26, 15 December 2011AlexanderPicoconverted more hugo to hgnc
46084view02:18, 15 December 2011AllanKuchinskySpecify description
46083view02:17, 15 December 2011AllanKuchinskyupdated HGNC IDs
46082view02:12, 15 December 2011AllanKuchinskySpecify description
46081view19:32, 14 December 2011AlexanderPicoconverted a couple HUGOs to HGNC
45197view10:06, 7 October 2011MartijnVanIerselOntology Term : 'p53 signaling pathway' added !
41219view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38810view08:13, 24 September 2010Jildaucompartments
38809view08:10, 24 September 2010Jildautransparent
38808view08:01, 24 September 2010JildauReverted to version '13:13, 23 September 2010' by Jildau
38807view08:01, 24 September 2010JildauReverted to version '07:53, 24 September 2010' by Jildau
38806view07:56, 24 September 2010JildauReverted to version '13:13, 23 September 2010' by Jildau
38805view07:53, 24 September 2010Jildaucompartments
38658view13:13, 23 September 2010Mkutmonadded pathway links for "apoptosis", "dna damage response", "cell cycle"
33421view14:52, 30 November 2009MaintBotRemoved group label
30260view04:51, 25 July 2009AlexanderPicoModified categories
29695view07:30, 28 May 2009I379077Modified description
29688view13:25, 27 May 2009I379077Modified description
29679view13:05, 26 May 2009I379077Specify description
29678view12:53, 26 May 2009I379077Specify description
29677view12:49, 26 May 2009I379077Specify description
29676view12:14, 26 May 2009I379077Modified description
29665view09:28, 25 May 2009I379077Modified description
29664view09:21, 25 May 2009I379077Specify description
29663view08:48, 25 May 2009I379077Specify description
29662view08:46, 25 May 2009I379077Specify description
29554view07:39, 15 May 2009I379077Specify description
29546view14:45, 14 May 2009I379077Specify description
29544view11:28, 14 May 2009I379077Specify description
29543view09:46, 14 May 2009I379077Specify description
29539view14:51, 13 May 2009I379077Specify description
29532view10:57, 12 May 2009I379077Specify description
29530view09:17, 12 May 2009I379077Specify description
29529view08:40, 12 May 2009I379077Specify description
29528view08:07, 12 May 2009I379077Specify description
29514view15:02, 11 May 2009I379077Specify description
29513view15:00, 11 May 2009I379077New pathway

External references


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NameTypeDatabase referenceComment
ABL1GeneProductENSG00000097007 (Ensembl)
AKT1GeneProductAKT1 (HGNC)
AKT2GeneProductAKT2 (HGNC)
AKT3GeneProductAKT3 (HGNC)
APCGeneProduct324 (Entrez Gene)
APCGeneProductENSG00000134982 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
Apoptosis PathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductBBC3 (HGNC)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BCL6GeneProductENSG00000113916 (Ensembl)
BIKGeneProductENSG00000100290 (Ensembl)
CATGeneProductENSG00000121691 (Ensembl)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNG2GeneProductENSG00000138764 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
Cell CyclePathwayWP179 (WikiPathways)
DNA damage responsePathwayWP1530 (WikiPathways)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
ERBB2GeneProductENSG00000141736 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FOXO3GeneProductENSG00000118689 (Ensembl)
FRAT1GeneProduct10023 (Entrez Gene)
G6PCGeneProductENSG00000131482 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
HMGB1GeneProductENSG00000189403 (Ensembl)
HRASGeneProduct3265 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LDLRGeneProduct3949 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K4GeneProductENSG00000085511 (Ensembl)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK2GeneProduct5594 (Entrez Gene)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProduct5601 (Entrez Gene)
MAPK9GeneProductENSG00000050748 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MLKLGeneProductENSG00000168404 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NFKB1GeneProductNFKB1 (HGNC)
NFKB2GeneProductNFKB2 (HGNC)
NRASGeneProduct4893 (Entrez Gene)
PDK1GeneProductENSG00000152256 (Ensembl)
PEPCKGeneProduct5106 (Entrez Gene)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2BGeneProduct5287 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PIK3R5GeneProduct23533 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PPP2R5CGeneProduct5527 (Entrez Gene)
PPP2R5EGeneProduct5529 (Entrez Gene)
PTENGeneProductENSG00000171862 (Ensembl)
RAC1GeneProduct5879 (Entrez Gene)
RAC1GeneProductENSG00000136238 (Ensembl)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductRAC3 (HGNC)
RBL2GeneProductENSG00000103479 (Ensembl)
RHOAGeneProduct387 (Entrez Gene)
SCP2GeneProductENSG00000116171 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOD2GeneProductENSG00000112096 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCF-1GeneProduct6932 (Entrez Gene)
TCF-3GeneProduct83439 (Entrez Gene)
TCF-4GeneProduct6934 (Entrez Gene)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBGeneProduct7040 (Entrez Gene)
TP53GeneProductENSG00000141510 (Ensembl)
TP73GeneProductENSG00000078900 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
c-MycGeneProduct4609 (Entrez Gene)

Annotated Interactions

No annotated interactions

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