DNA damage response (only ATM dependent) (Homo sapiens)

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This is one of two pathways that deal with DNA damage. It has two central gene products (ATM and TP53) which are connected with the other DNA damage response pathway.

In this pathway there is only one source of DNA damage induction, since most DNA damage induction sources and their involvement are mentioned in the first DNA damage response pathway. If it is not mentioned differently, the processes take place in the cell cytoplasm. The purpose of this pathway is to report more gene products and cell condition changes through the DNA damage response pathway and at the same time keep them clearly arranged.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



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  5. Chargari C, Toillon RA, Macdermed D, Castadot P, Magnأ¯آ؟آ½أ¯آ؟آ½أژآ© N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC Scholia
  6. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
  7. Lأ¯آ؟آ½أ¯آ؟آ½أژآ©brich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
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116542view12:11, 7 May 2021EweitzModified title
113791view08:53, 24 November 2020Finterlymake pathways clickable and small graphical update
109435view10:17, 17 March 2020L DupuisConverted interaction to graphical line in legend
106372view00:55, 23 August 2019KhanspersModified description
105500view05:53, 8 August 2019KhanspersModified description
105238view20:32, 23 July 2019Khansperslayout changes and updated legend
104836view14:14, 20 June 2019Fehrhartinteraction between CTNNB1 and TCF complex
104835view14:12, 20 June 2019Fehrhart
104833view13:59, 20 June 2019Fehrhart
104309view21:41, 15 May 2019Khanspersupdated legend, clarified phosphorylation of CTNNB1, unified fonts, cleanup
104308view21:00, 15 May 2019KhanspersModified description
104307view20:59, 15 May 2019KhanspersModified description
95580view03:04, 3 January 2018Asios OliaModified description
94761view15:50, 5 October 2017Ryanmillerconnected lines
79974view08:10, 29 April 2015ZariChanged uniprot Id to Entrez gene for RAS, PI3K and TCF-1/LEF genes
70109view19:06, 12 July 2013MaintBotupdating to 2013 schema
69906view19:31, 11 July 2013AlexanderPicoModified title
67156view10:14, 26 June 2013Christine ChichesterOntology Term : 'p53-dependent G1/S DNA damage checkpoint pathway' added !
59215view20:07, 22 February 2013MaintBotUpdated Ensembl data source
46091view03:26, 15 December 2011AlexanderPicoconverted more hugo to hgnc
46084view02:18, 15 December 2011AllanKuchinskySpecify description
46083view02:17, 15 December 2011AllanKuchinskyupdated HGNC IDs
46082view02:12, 15 December 2011AllanKuchinskySpecify description
46081view19:32, 14 December 2011AlexanderPicoconverted a couple HUGOs to HGNC
45197view10:06, 7 October 2011MartijnVanIerselOntology Term : 'p53 signaling pathway' added !
41219view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38810view08:13, 24 September 2010Jildaucompartments
38809view08:10, 24 September 2010Jildautransparent
38808view08:01, 24 September 2010JildauReverted to version '13:13, 23 September 2010' by Jildau
38807view08:01, 24 September 2010JildauReverted to version '07:53, 24 September 2010' by Jildau
38806view07:56, 24 September 2010JildauReverted to version '13:13, 23 September 2010' by Jildau
38805view07:53, 24 September 2010Jildaucompartments
38658view13:13, 23 September 2010Mkutmonadded pathway links for "apoptosis", "dna damage response", "cell cycle"
33421view14:52, 30 November 2009MaintBotRemoved group label
30260view04:51, 25 July 2009AlexanderPicoModified categories
29695view07:30, 28 May 2009I379077Modified description
29688view13:25, 27 May 2009I379077Modified description
29679view13:05, 26 May 2009I379077Specify description
29678view12:53, 26 May 2009I379077Specify description
29677view12:49, 26 May 2009I379077Specify description
29676view12:14, 26 May 2009I379077Modified description
29665view09:28, 25 May 2009I379077Modified description
29664view09:21, 25 May 2009I379077Specify description
29663view08:48, 25 May 2009I379077Specify description
29662view08:46, 25 May 2009I379077Specify description
29554view07:39, 15 May 2009I379077Specify description
29546view14:45, 14 May 2009I379077Specify description
29544view11:28, 14 May 2009I379077Specify description
29543view09:46, 14 May 2009I379077Specify description
29539view14:51, 13 May 2009I379077Specify description

External references


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NameTypeDatabase referenceComment
ABL1GeneProductENSG00000097007 (Ensembl)
AKT1GeneProductAKT1 (HGNC)
AKT2GeneProductAKT2 (HGNC)
AKT3GeneProductAKT3 (HGNC)
APCGeneProduct324 (Entrez Gene)
APCGeneProductENSG00000134982 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
Apoptosis PathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductBBC3 (HGNC)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BCL6GeneProductENSG00000113916 (Ensembl)
BIKGeneProductENSG00000100290 (Ensembl)
CATGeneProductENSG00000121691 (Ensembl)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNG2GeneProductENSG00000138764 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
Cell CyclePathwayWP179 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
ERBB2GeneProductENSG00000141736 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FOXO3GeneProductENSG00000118689 (Ensembl)
FRAT1GeneProduct10023 (Entrez Gene)
G6PCGeneProductENSG00000131482 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
HMGB1GeneProductENSG00000189403 (Ensembl)
HRASGeneProduct3265 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LDLRGeneProduct3949 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K4GeneProductENSG00000085511 (Ensembl)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK2GeneProduct5594 (Entrez Gene)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProduct5601 (Entrez Gene)
MAPK9GeneProductENSG00000050748 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MLKLGeneProductENSG00000168404 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NFKB1GeneProductNFKB1 (HGNC)
NFKB2GeneProductNFKB2 (HGNC)
NRASGeneProduct4893 (Entrez Gene)
PDK1GeneProductENSG00000152256 (Ensembl)
PEPCKGeneProduct5106 (Entrez Gene)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2BGeneProduct5287 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PIK3R5GeneProduct23533 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PPP2R5CGeneProduct5527 (Entrez Gene)
PPP2R5EGeneProduct5529 (Entrez Gene)
PTENGeneProductENSG00000171862 (Ensembl)
RAC1GeneProduct5879 (Entrez Gene)
RAC1GeneProductENSG00000136238 (Ensembl)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductRAC3 (HGNC)
RBL2GeneProductENSG00000103479 (Ensembl)
RHOAGeneProduct387 (Entrez Gene)
SCP2GeneProductENSG00000116171 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOD2GeneProductENSG00000112096 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCF-1GeneProduct6932 (Entrez Gene)
TCF-3GeneProduct83439 (Entrez Gene)
TCF-4GeneProduct6934 (Entrez Gene)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBGeneProduct7040 (Entrez Gene)
TP53GeneProductENSG00000141510 (Ensembl)
TP73GeneProductENSG00000078900 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
c-MycGeneProduct4609 (Entrez Gene)

Annotated Interactions

No annotated interactions

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