Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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11488512280464265628112773, 9531187011133, 1171310632, 62, 932812510755975236316852631193197366, 25, 54316097338682411199982825823119108421031045910316103162416594242, 7716103161645, 74168410342, 7716421616Sph: SIDS Phenotype Animal ModelGq signalingNucleusOtherIncreased long-QT with SIDS Slowly-Activating K+ Current4R/4RSerotonin Synthesis and MetabolismG2989T2SPhSerotoninTransporterFocal AdhesionsSarcoplasmic ReticulumPutative TRSleepMiscelaneous SIDS AssociatedPutative TRSoma Membranep+Gi signalingPutative TRsDecreased relative SIDS expressionGs signalingBrainstem neuronPutative TRPutative TRPutative TRsPutative TRsG-proteinSPhrs2856966Putative TRs BrownAdiposeIncreased brainstem hypoplasia with SIDSHOPutative TRCell MembraneG5477ANerve TerminalHNNa+HeartThermoregulationSPhSIDS associated polymorphismsTRrBradycardiaSerotonin SignalingCardiac myocyteK+K+Putative TRs2+SPhIncreased relative SIDS expressionInfant (<1 year in age)SIDS Susceptibility PathwaysAssociated with Energy Metabolism and SIDSPutative TRPutative TRsVagal ToneNHIVS-191_190insAC825TRapidly-activating K+ CurrentPutative TRsPutative TRStabilizationCacircadiandepressionTRrBrainTR: Transcriptional RegulationAssociated with Infection and SIDSNucleus6122846614617929623KCNQ1ASCL1AVPDDCTLX3L-TryptophanKCNH2 HTR1APBX1RETCAV3THRBRESTEP300NR3C1IL6C4ATACR1NKX2-2CC2D1AEGR1FEV5-HIAASCN5ASP3RESTMIR16-1RYR2CHRNB4ADCYAP1C4BESR2POU3F2NR3C1CDCA7LMIR210IL10ECE1NEUROD1Nicotine5-HTPGATA3RORAPLP1RUNX3ADCYAP1IL6RSSTR1PKNOX1Glial Cell DifferentiationKCNQ1MAOAPPARGC1BHES1CREB1CHRNA4HTR1AMAZSP1ALDOAPOU3F2KCNH2TPH1ADCYAP1R15-HTSP1TPH25-HTNFKB1RESTFluoxetineTNFPHOX2BVIPR2MIR13ADEAF1HES1DDCNKX3-1SP1CTCFHIF1ATPH2FOXM1CAV3SSTR2PHOX2A5-HTJUNIL8NGFFEVTP73GATA2ACADMYBX1PPARGC1ARYR2HES5ARSLC6A4GNB3LMX1BCREB1HIF1AMAOAVIPR1NFYAHADHABHLHE40HTR2ADLX2CREBBPNFKB1RESTTCF3RESTTPH1CREB1SP1HSPD1SP1MEF2CEN1456210010533987882373912419, 1161151510439616929110981091178940145347113311217671Putative TRsCTNNB1SOX2NANOGPOU5F171MAPK pathway42BDNFNTRK2Gi signalingGABA112GABRA1CHRM2123GJA118SNTA1Na+H+49K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction11SLC9A3CASP3FMO3G6PC35GCK44GPD1L66GRIN1HADHB102HTR3ASCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia275-HTGlutamateCa2+34H2OH2OAQP4ApoptosisCPT1A94IL1A120IL1B120IL1RN67IL1358TSPYL157VEGFASCN5A4830DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDC75NOS1APGq signalingMAP2TAC12MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamate2SST2TAC1HTR3ATH5188CHAT10484SLC9A3BDNF42NTRK2AQP4344GRIN1SP1NFKB2101JUN20HDAC9MYB79CEBPB80SNTA118GPD1LSP1JUNNR3C1REST118JUN26CREB1POU2F250CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA1112CREB156VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs9931