Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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438276275770109419884, 38, 107441142, 8611151291211671431, 661222026237560371251206637967211336362323367212376422, 24, 59379136607120794878953579787868, 8778787840784054, 95954011478789528404054, 9578Cell MembraneDecreased relative SIDS expressionSPhK+Increased long-QT with SIDSPutative TRRapidly-activating K+ CurrentSerotoninTransporter2 Slowly-Activating K+ CurrentGi signalingK+Putative TRPutative TRsNHSph: SIDS Phenotype Animal ModelPutative TRHeartSIDS associated polymorphismsPutative TRsStabilizationHNPutative TRsSPhTRrCardiac myocyteSIDS Susceptibility PathwaysPutative TRSPhPutative TRHOIVS-191_190insAcircadianVagal Tone BrownAdiposeAssociated with Energy Metabolism and SIDSG2989TSerotonin SignalingBrainPutative TROtherNucleusBradycardiaPutative TRsFocal AdhesionsInfant (<1 year in age)Soma MembraneCaTRrIncreased relative SIDS expressionGq signalingIncreased brainstem hypoplasia with SIDSNucleusG5477AAssociated with Infection and SIDSNa+C825Trs28569664R/4RPutative TR2+Brainstem neuronSerotonin Synthesis and MetabolismG-proteinSleepp+Gs signalingMiscelaneous SIDS AssociatedPutative TRsPutative TRsdepressionSarcoplasmic ReticulumThermoregulationPutative TRsNerve TerminalTR: Transcriptional RegulationSPh11511956693248123972456CREB1FEVRESTIL6CAV3HADHASP1MIR13ARETHSPD1PPARGC1AMAOAIL6RPOU3F2SP1CTCFRESTMAZPKNOX1TP73TPH1TNFVIPR2TACR1SSTR1PLP1POU3F2HES5ACADMASCL1MIR16-15-HTALDOAKCNH2KCNQ1CC2D1ASLC6A4GNB3CHRNB4MIR210C4A5-HTPDDCPBX1FEVFOXM1HES1NEUROD1HTR2AGATA3NFYADDCTLX3CAV3Glial Cell DifferentiationCDCA7LNKX3-1L-TryptophanPHOX2BMAOAHIF1AVIPR1TCF3AVPKCNQ1HTR1AFluoxetineNGFSCN5ACREBBPSP1DEAF1HTR1AADCYAP1RORAEP300ADCYAP1R1ECE1RUNX3THRBNFKB1BHLHE40PHOX2ANR3C1SP3EN1LMX1BJUNEGR1CREB15-HTIL10RESTDLX2SSTR2PPARGC1BADCYAP1TPH2ESR2NKX2-25-HTNFKB1RESTCREB1SP15-HIAARYR2HES1CHRNA4RYR2GATA2TPH2TPH1NR3C1YBX1SP1IL8RESTKCNH2 NicotineC4BARMEF2CHIF1A108311051101710250304911236133746679068321215312496, 1044663984526511711810049335Putative TRsCTNNB1SOX2NANOGPOU5F15MAPK pathway95BDNFNTRK2Gi signalingGABAGABRA18358CHRM2GJA145SNTA1Na+H+14K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction55SLC9A3CASP3FMO361G6PC85GCK25GPD1LGRIN1HADHBHTR3A80SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia925-HTGlutamateCa2+106H2OH2OAQP4ApoptosisCPT1A101IL1AIL1B6IL1RN6IL136389TSPYL177VEGFASCN5A1518DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP98Gq signalingMAP241TAC1MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamate41SSTTAC141HTR3ATH7682CHAT35114SLC9A3BDNF95NTRK2AQP410670GRIN1SP199NFKB2JUN94HDAC9MYB73CEBPB57SNTA145GPD1LSP1JUNNR3C144REST19JUNCREB1POU2F247CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRr83GABRA1CREB181VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs12536