Sudden infant death syndrome (SIDS) susceptibility pathways (Homo sapiens)

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438276275770109415142, 8688712631, 66911224, 38, 107201621294441111122, 24, 5937372323606012036367919611372753712523367237641212066361147895787878797840954878354095784054, 957868, 8779407854, 95402878Brainstem neuronPutative TRsHNG2989TcircadianSPhGs signalingSoma MembraneIncreased relative SIDS expressionSPhTRrSph: SIDS Phenotype Animal Model2 Slowly-Activating K+ CurrentSIDS Susceptibility Pathways2+Associated with Energy Metabolism and SIDSMiscelaneous SIDS AssociatedPutative TRsPutative TRDecreased relative SIDS expression4R/4RNucleusStabilizationHeartPutative TRsNHNucleusPutative TRsp+K+Putative TRsPutative TRdepressionRapidly-activating K+ Currentrs2856966Putative TRsBrainSarcoplasmic ReticulumG5477AThermoregulationTR: Transcriptional RegulationSerotoninTransporterSerotonin SignalingK+Serotonin Synthesis and MetabolismInfant (<1 year in age)Putative TRCell MembraneGi signalingPutative TRHOIncreased long-QT with SIDSVagal ToneSPhGq signalingSleep BrownAdiposePutative TRG-proteinPutative TRIVS-191_190insAOtherNerve TerminalIncreased brainstem hypoplasia with SIDSTRrCaPutative TRC825TPutative TRsNa+Cardiac myocyteSIDS associated polymorphismsSPhAssociated with Infection and SIDSBradycardiaFocal Adhesions24119698324115123565697MAOAGATA2VIPR2PPARGC1B5-HTCHRNA4RESTNFKB1KCNQ1TPH1BHLHE40HES5MIR210SSTR2SLC6A4ADCYAP1PLP1SCN5APHOX2BRESTNicotineVIPR1YBX1HIF1ATPH2SP1MAOAKCNQ1CAV3TCF3IL6RCAV3C4AEN1FluoxetineNFYAHES15-HIAADLX2EP300LMX1BFEVC4BTPH2RETHES1SP1RUNX3EGR1NGFRORACC2D1ARESTPHOX2AAVPFEVCREB1SP1GATA3NR3C1SP3ALDOAL-TryptophanSP1NR3C1TP73POU3F2HTR2AJUNADCYAP1R1MAZKCNH2 Glial Cell DifferentiationIL10IL8ACADMCREB1MIR13ANKX2-2HTR1ATACR1GNB3AR5-HTESR2ECE1RESTHADHANKX3-1PPARGC1AKCNH2CDCA7LTHRBTLX3RYR2MIR16-1RYR2NFKB1ASCL1DDCPKNOX1DDCIL6TNFMEF2CADCYAP1NEUROD1HTR1ATPH1HSPD1CHRNB45-HTSP1CREB1REST5-HTPFOXM1HIF1ASSTR1POU3F2CREBBPPBX1CTCFDEAF1503368171021245246494301171310066373211210512136493196, 1043965118679010853841105Putative TRsCTNNB1SOX2NANOGPOU5F15MAPK pathway95BDNFNTRK2Gi signalingGABAGABRA18358CHRM2GJA145SNTA1Na+H+14K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction55SLC9A3CASP3FMO361G6PCGCK85GPD1L25GRIN1HADHBHTR3A80SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia925-HTGlutamateCa2+106H2OH2OAQP4ApoptosisCPT1AIL1A101IL1B66IL1RN63IL1389TSPYL177VEGFASCN5A1518DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP98Gq signalingMAP241TAC1MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamate41SST41TAC1HTR3A76TH82CHAT35114SLC9A3BDNFNTRK295AQP4106GRIN170SP1NFKB299JUNHDAC994MYB73CEBPB57SNTA145GPD1LSP1JUNNR3C144REST19JUNCREB1POU2F247CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRr83GABRA1CREB181VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs12536