Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)
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43
82
76
27
57
70
109
41
9
42, 86
4, 38, 107
44
11
21
111
51
71
1
88
16
29
4
31, 66
122
20
26
37
75
22, 24, 59
37
125
120
23
66
96
72
113
36
36
60
36
72
12
37
64
23
37
91
36
60
23
7
120
79
48
95
95
54, 95
79
78
78
78
78
78
78
40
78
40
114
54, 95
40
35
68, 87
78
95
28
40
40
78
78
Cell Membrane
Decreased relative SIDS expression
SPh
K+
Increased long-QT with SIDS
Putative TR
Rapidly-activating K+ Current
Serotonin
Transporter
2
Slowly-Activating K+ Current
Gi signaling
K+
Putative TR
Putative TRs
NH
Sph: SIDS Phenotype Animal Model
Putative TR
Heart
SIDS associated polymorphisms
Putative TRs
Stabilization
HN
Putative TRs
SPh
TRr
Cardiac myocyte
SIDS Susceptibility Pathways
Putative TR
SPh
Putative TR
HO
IVS-191_190insA
circadian
Vagal Tone
Brown
Adipose
Associated with Energy Metabolism and SIDS
G2989T
Serotonin Signaling
Brain
Putative TR
Other
Nucleus
Bradycardia
Putative TRs
Focal Adhesions
Infant (<1 year in age)
Soma Membrane
Ca
TRr
Increased relative SIDS expression
Gq signaling
Increased brainstem hypoplasia with SIDS
Nucleus
G5477A
Associated with Infection and SIDS
Na+
C825T
rs2856966
4R/4R
Putative TR
2+
Brainstem neuron
Serotonin Synthesis and Metabolism
G-protein
Sleep
p+
Gs signaling
Miscelaneous SIDS Associated
Putative TRs
Putative TRs
depression
Sarcoplasmic Reticulum
Thermoregulation
Putative TRs
Nerve Terminal
TR: Transcriptional Regulation
SPh
115
24
119
69
3
24
56
123
8
97
56
CREB1
FEV
EGR1
AVP
CAV3
ESR2
SP1
PBX1
PHOX2A
HSPD1
PPARGC1A
MAOA
IL6
POU3F2
TP73
5-HTP
NFKB1
REST
SP1
HIF1A
TPH1
DDC
VIPR2
SSTR2
Fluoxetine
THRB
POU3F2
HES5
HADHA
ASCL1
JUN
5-HT
Glial Cell Differentiation
GNB3
Nicotine
CC2D1A
SLC6A4
EP300
CHRNB4
NR3C1
C4A
REST
PKNOX1
FEV
FOXM1
CREBBP
HES1
5-HT
GATA3
NFYA
DDC
ECE1
ALDOA
CAV3
PLP1
CDCA7L
NKX3-1
L-Tryptophan
PHOX2B
MAOA
TACR1
VIPR1
BHLHE40
RORA
KCNQ1
HTR1A
MIR16-1
MIR13A
KCNH2
NGF
SP1
DEAF1
HTR1A
ADCYAP1
SCN5A
KCNQ1
ADCYAP1R1
RET
DLX2
HIF1A
NFKB1
REST
HTR2A
NR3C1
MEF2C
TLX3
LMX1B
IL8
SP1
RUNX3
5-HT
IL10
REST
TCF3
SSTR1
TNF
PPARGC1B
TPH2
EN1
NKX2-2
IL6R
MIR210
ADCYAP1
SP3
CREB1
5-HIAA
RYR2
HES1
CHRNA4
RYR2
GATA2
TPH2
TPH1
NEUROD1
YBX1
SP1
ACADM
REST
KCNH2
CTCF
C4B
AR
MAZ
CREB1
108
31
105
110
17
102
50
30
49
112
36
13
37
46
67
90
68
32
121
53
124
96, 104
4
66
39
84
52
65
117
118
100
49
33
5
Putative TRs
CTNNB1
SOX2
NANOG
POU5F1
5
MAPK pathway
95
BDNF
NTRK2
Gi signaling
GABA
83
GABRA1
58
CHRM2
GJA1
45
SNTA1
Na+
H+
14
K+
KCNJ8
GJA1
PKC inhibitor 14-3-3
Protein Kinase A
PRKAR2B
YWHAE
YWHAZ
PRKAR1B
PRKAR2A
YWHAQ
YWHAG
PRKAR1A
YWHAH
YWHAB
PRKACB
PRKACA
Activation
GAP Junction
55
SLC9A3
CASP3
FMO3
G6PC
61
85
GCK
25
GPD1L
GRIN1
HADHB
HTR3A
80
SCN3B
SCN4B
SST
Na+
Cardiac Vagal
Excitation
Chronic
Hypoxia
92
5-HT
Glutamate
Ca2+
106
H2O
H2O
AQP4
Apoptosis
CPT1A
101
IL1A
IL1B
6
IL1RN
6
63
IL13
89
TSPYL1
VEGFA
77
SCN5A
15
18
Dopamine
Phenylalanine
CHAT
L-DOPA
PAH
Acetylcholine
Choline
TH
Tyrosine
DDC
NOS1AP
98
Gq signaling
MAP2
TAC1
41
Microtuble
Stabilization
SLC1A3
SLC25A4
Glutamate
SNAP25
Synaptic Vesicle Release
Glutamate
SST
41
41
TAC1
HTR3A
TH
76
82
CHAT
35
114
SLC9A3
BDNF
NTRK2
95
106
AQP4
70
GRIN1
SP1
99
NFKB2
JUN
94
HDAC9
MYB
73
CEBPB
57
SNTA1
45
GPD1L
SP1
JUN
NR3C1
REST
44
JUN
19
CREB1
POU2F2
47
CREM
REST
NFKB1
CHRNB2
CHRNA7
Serotonergic Neurons
HDAC1
MBD1
MECP2
NFKB1
CREBBP
TRr
TRr
GABRA1
83
CREB1
81
VAMP2
Extracellular Space
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
TPPP
ATP1A3
GAPDH
HSP90B1
TF
SPTBN1
YWHAG
HIF1A
Putative TRs
125
36