Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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43827627577010941942, 864, 38, 10744112111151711881629431, 661222026377522, 24, 593712512023669672113363660367212376423379136602371207948959554, 957978787878787840784011454, 95403568, 8778952840407878Cell MembraneDecreased relative SIDS expressionSPhK+Increased long-QT with SIDSPutative TRRapidly-activating K+ CurrentSerotoninTransporter2 Slowly-Activating K+ CurrentGi signalingK+Putative TRPutative TRsNHSph: SIDS Phenotype Animal ModelPutative TRHeartSIDS associated polymorphismsPutative TRsStabilizationHNPutative TRsSPhTRrCardiac myocyteSIDS Susceptibility PathwaysPutative TRSPhPutative TRHOIVS-191_190insAcircadianVagal Tone BrownAdiposeAssociated with Energy Metabolism and SIDSG2989TSerotonin SignalingBrainPutative TROtherNucleusBradycardiaPutative TRsFocal AdhesionsInfant (<1 year in age)Soma MembraneCaTRrIncreased relative SIDS expressionGq signalingIncreased brainstem hypoplasia with SIDSNucleusG5477AAssociated with Infection and SIDSNa+C825Trs28569664R/4RPutative TR2+Brainstem neuronSerotonin Synthesis and MetabolismG-proteinSleepp+Gs signalingMiscelaneous SIDS AssociatedPutative TRsPutative TRsdepressionSarcoplasmic ReticulumThermoregulationPutative TRsNerve TerminalTR: Transcriptional RegulationSPh11524119693245612389756CREB1FEVEGR1AVPCAV3ESR2SP1PBX1PHOX2AHSPD1PPARGC1AMAOAIL6POU3F2TP735-HTPNFKB1RESTSP1HIF1ATPH1DDCVIPR2SSTR2FluoxetineTHRBPOU3F2HES5HADHAASCL1JUN5-HTGlial Cell DifferentiationGNB3NicotineCC2D1ASLC6A4EP300CHRNB4NR3C1C4ARESTPKNOX1FEVFOXM1CREBBPHES15-HTGATA3NFYADDCECE1ALDOACAV3PLP1CDCA7LNKX3-1L-TryptophanPHOX2BMAOATACR1VIPR1BHLHE40RORAKCNQ1HTR1AMIR16-1MIR13AKCNH2NGFSP1DEAF1HTR1AADCYAP1SCN5AKCNQ1ADCYAP1R1RETDLX2HIF1ANFKB1RESTHTR2ANR3C1MEF2CTLX3LMX1BIL8SP1RUNX35-HTIL10RESTTCF3SSTR1TNFPPARGC1BTPH2EN1NKX2-2IL6RMIR210ADCYAP1SP3CREB15-HIAARYR2HES1CHRNA4RYR2GATA2TPH2TPH1NEUROD1YBX1SP1ACADMRESTKCNH2 CTCFC4BARMAZCREB1108311051101710250304911236133746679068321215312496, 1044663984526511711810049335Putative TRsCTNNB1SOX2NANOGPOU5F15MAPK pathway95BDNFNTRK2Gi signalingGABA83GABRA158CHRM2GJA145SNTA1Na+H+14K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction55SLC9A3CASP3FMO3G6PC6185GCK25GPD1LGRIN1HADHBHTR3A80SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia925-HTGlutamateCa2+106H2OH2OAQP4ApoptosisCPT1A101IL1AIL1B6IL1RN663IL1389TSPYL1VEGFA77SCN5A1518DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP98Gq signalingMAP2TAC141MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamateSST4141TAC1HTR3ATH7682CHAT35114SLC9A3BDNFNTRK295106AQP470GRIN1SP199NFKB2JUN94HDAC9MYB73CEBPB57SNTA145GPD1LSP1JUNNR3C1REST44JUN19CREB1POU2F247CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA183CREB181VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs12536