Sudden infant death syndrome (SIDS) susceptibility pathways (Homo sapiens)
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76
27
57
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109
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51
42, 86
88
71
26
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9
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122
4, 38, 107
20
16
21
29
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11
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22, 24, 59
37
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23
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60
120
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36
7
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113
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37
125
23
36
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12
120
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114
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35
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54, 95
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68, 87
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28
78
Brainstem neuron
Putative TRs
HN
G2989T
circadian
SPh
Gs signaling
Soma Membrane
Increased relative SIDS expression
SPh
TRr
Sph: SIDS Phenotype Animal Model
2
Slowly-Activating K+ Current
SIDS Susceptibility Pathways
2+
Associated with Energy Metabolism and SIDS
Miscelaneous SIDS Associated
Putative TRs
Putative TR
Decreased relative SIDS expression
4R/4R
Nucleus
Stabilization
Heart
Putative TRs
NH
Nucleus
Putative TRs
p+
K+
Putative TRs
Putative TR
depression
Rapidly-activating K+ Current
rs2856966
Putative TRs
Brain
Sarcoplasmic Reticulum
G5477A
Thermoregulation
TR: Transcriptional Regulation
Serotonin
Transporter
Serotonin Signaling
K+
Serotonin Synthesis and Metabolism
Infant (<1 year in age)
Putative TR
Cell Membrane
Gi signaling
Putative TR
HO
Increased long-QT with SIDS
Vagal Tone
SPh
Gq signaling
Sleep
Brown
Adipose
Putative TR
G-protein
Putative TR
IVS-191_190insA
Other
Nerve Terminal
Increased brainstem hypoplasia with SIDS
TRr
Ca
Putative TR
C825T
Putative TRs
Na+
Cardiac myocyte
SIDS associated polymorphisms
SPh
Associated with Infection and SIDS
Bradycardia
Focal Adhesions
24
119
69
8
3
24
115
123
56
56
97
MAOA
GATA2
VIPR2
PPARGC1B
5-HT
CHRNA4
REST
NFKB1
KCNQ1
TPH1
BHLHE40
HES5
MIR210
SSTR2
SLC6A4
ADCYAP1
PLP1
SCN5A
PHOX2B
REST
Nicotine
VIPR1
YBX1
HIF1A
TPH2
SP1
MAOA
KCNQ1
CAV3
TCF3
IL6R
CAV3
C4A
EN1
Fluoxetine
NFYA
HES1
5-HIAA
DLX2
EP300
LMX1B
FEV
C4B
TPH2
RET
HES1
SP1
RUNX3
EGR1
NGF
RORA
CC2D1A
REST
PHOX2A
AVP
FEV
CREB1
SP1
GATA3
NR3C1
SP3
ALDOA
L-Tryptophan
SP1
NR3C1
TP73
POU3F2
HTR2A
JUN
ADCYAP1R1
MAZ
KCNH2
Glial Cell Differentiation
IL10
IL8
ACADM
CREB1
MIR13A
NKX2-2
HTR1A
TACR1
GNB3
AR
5-HT
ESR2
ECE1
REST
HADHA
NKX3-1
PPARGC1A
KCNH2
CDCA7L
THRB
TLX3
RYR2
MIR16-1
RYR2
NFKB1
ASCL1
DDC
PKNOX1
DDC
IL6
TNF
MEF2C
ADCYAP1
NEUROD1
HTR1A
TPH1
HSPD1
CHRNB4
5-HT
SP1
CREB1
REST
5-HTP
FOXM1
HIF1A
SSTR1
POU3F2
CREBBP
PBX1
CTCF
DEAF1
50
33
68
17
102
124
52
46
49
4
30
117
13
100
66
37
32
112
105
121
36
49
31
96, 104
39
65
118
67
90
108
53
84
110
5
Putative TRs
CTNNB1
SOX2
NANOG
POU5F1
5
MAPK pathway
95
BDNF
NTRK2
Gi signaling
GABA
GABRA1
83
58
CHRM2
GJA1
45
SNTA1
Na+
H+
14
K+
KCNJ8
GJA1
PKC inhibitor 14-3-3
Protein Kinase A
PRKAR2B
YWHAE
YWHAZ
PRKAR1B
PRKAR2A
YWHAQ
YWHAG
PRKAR1A
YWHAH
YWHAB
PRKACB
PRKACA
Activation
GAP Junction
55
SLC9A3
CASP3
FMO3
61
G6PC
GCK
85
GPD1L
25
GRIN1
HADHB
HTR3A
80
SCN3B
SCN4B
SST
Na+
Cardiac Vagal
Excitation
Chronic
Hypoxia
92
5-HT
Glutamate
Ca2+
106
H2O
H2O
AQP4
Apoptosis
CPT1A
IL1A
101
IL1B
6
6
IL1RN
63
IL13
89
TSPYL1
77
VEGFA
SCN5A
15
18
Dopamine
Phenylalanine
CHAT
L-DOPA
PAH
Acetylcholine
Choline
TH
Tyrosine
DDC
NOS1AP
98
Gq signaling
MAP2
41
TAC1
Microtuble
Stabilization
SLC1A3
SLC25A4
Glutamate
SNAP25
Synaptic Vesicle Release
Glutamate
41
SST
41
TAC1
HTR3A
76
TH
82
CHAT
35
114
SLC9A3
BDNF
NTRK2
95
AQP4
106
GRIN1
70
SP1
NFKB2
99
JUN
HDAC9
94
MYB
73
CEBPB
57
SNTA1
45
GPD1L
SP1
JUN
NR3C1
44
REST
19
JUN
CREB1
POU2F2
47
CREM
REST
NFKB1
CHRNB2
CHRNA7
Serotonergic Neurons
HDAC1
MBD1
MECP2
NFKB1
CREBBP
TRr
TRr
83
GABRA1
CREB1
81
VAMP2
Extracellular Space
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
Putative TRs
TPPP
ATP1A3
GAPDH
HSP90B1
TF
SPTBN1
YWHAG
HIF1A
Putative TRs
125
36