Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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4382762757701094111198847131, 66441212620114, 38, 1071642, 86511222937233766371203696602375726022, 24, 5923113643791721203636367121257840784078359554, 959540114787854, 9540787868, 87797878407995784828Putative TRSPhHeartSPhSIDS associated polymorphismsC825TIVS-191_190insArs28569662+TR: Transcriptional RegulationIncreased long-QT with SIDSOtherHNCell MembranePutative TRsPutative TRPutative TRGs signalingFocal AdhesionscircadianSleepSPhG2989TPutative TRsDecreased relative SIDS expression BrownAdiposePutative TRG-proteinNucleusPutative TRsNHGi signalingStabilizationTRrp+Putative TRsSIDS Susceptibility PathwaysPutative TRsSerotonin Synthesis and MetabolismK+SPh2HONucleusCaGq signalingG5477A Slowly-Activating K+ CurrentThermoregulationdepressionSerotoninTransporterSph: SIDS Phenotype Animal ModelAssociated with Infection and SIDSNerve TerminalNa+Associated with Energy Metabolism and SIDSBradycardiaPutative TRCardiac myocyteIncreased brainstem hypoplasia with SIDSPutative TRsPutative TRBrainstem neuronSoma MembraneBrainSerotonin SignalingTRrMiscelaneous SIDS AssociatedVagal ToneK+Increased relative SIDS expressionRapidly-activating K+ Current4R/4RPutative TRInfant (<1 year in age)Sarcoplasmic ReticulumPutative TRs12356869561199724241153HTR1APPARGC1BDLX2HTR2AFOXM1JUNHES1HES1EN1TNF5-HIAARYR2PHOX2AFEVMIR13AEP300SP3CREB1NGFPBX1ADCYAP1RESTMAOASP1HIF1AHSPD1CDCA7LMIR16-1PPARGC1AC4ASSTR2VIPR1AVPKCNH2LMX1BIL10RORANFKB1DEAF1MAZKCNQ1ADCYAP1CREBBPARTPH2MIR210NFKB1ECE1GATA2KCNQ1VIPR2HADHANKX3-1SLC6A45-HTFEVDDCPOU3F2CREB1PKNOX1ADCYAP1R1CREB15-HTCAV3PHOX2BTACR1NEUROD1IL6NR3C1BHLHE40ASCL1CHRNA4HES5IL6RSCN5APOU3F2ESR2THRBALDOARUNX3TLX3DDCSP1ACADMNR3C1SSTR1TCF3PLP1RYR2TPH1RESTYBX1HIF1ATP735-HTPCTCFC4BIL85-HTRETMEF2CNicotineEGR1RESTMAOAKCNH2 CC2D1ANKX2-2SP1CAV3TPH2GATA3RESTTPH1L-TryptophanFluoxetineRESTNFYAGNB3SP1CHRNB4SP1Glial Cell DifferentiationHTR1A5311067664912132395250316836371396, 104105118659011710284449100112333046171081245Putative TRsCTNNB1SOX2NANOGPOU5F15MAPK pathway95BDNFNTRK2Gi signalingGABAGABRA18358CHRM2GJA145SNTA1Na+H+14K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction55SLC9A3CASP3FMO361G6PC85GCK25GPD1LGRIN1HADHBHTR3A80SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia925-HTGlutamateCa2+106H2OH2OAQP4ApoptosisCPT1A101IL1A6IL1B6IL1RNIL136389TSPYL177VEGFASCN5A1518DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP98Gq signalingMAP241TAC1MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamateSST4141TAC1HTR3A76THCHAT8235114SLC9A3BDNFNTRK295AQP4106GRIN170SP1NFKB299JUN94HDAC973MYBCEBPB57SNTA145GPD1LSP1JUNNR3C1REST44JUN19CREB1POU2F247CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA183CREB181VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs12536