Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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4382762757701094126142, 8612251201129164498831, 664, 38, 10721411171236012609112037722, 24, 59125120729636233766367537726436113362337789578407895287878403578951144048784054, 957854, 95407968, 87797878NHNucleusSIDS Susceptibility PathwaysThermoregulationOtherSoma MembranePutative TRsSph: SIDS Phenotype Animal ModelTR: Transcriptional RegulationG2989TG-proteinMiscelaneous SIDS AssociatedNa+IVS-191_190insABrainC825TAssociated with Infection and SIDS BrownAdiposeSPhIncreased relative SIDS expressionAssociated with Energy Metabolism and SIDSPutative TRsp+SPhPutative TRsCardiac myocyteNucleusRapidly-activating K+ CurrentBradycardiaInfant (<1 year in age)SleepSPhSerotoninTransporterDecreased relative SIDS expressionStabilizationPutative TR4R/4RFocal AdhesionsK+Putative TRsTRr Slowly-Activating K+ CurrentNerve TerminalCaTRrHNPutative TRPutative TRsPutative TRPutative TRSPhIncreased long-QT with SIDSHOPutative TRPutative TRsVagal ToneG5477APutative TRSerotonin SignalingGi signalingSarcoplasmic ReticulumcircadianSIDS associated polymorphismsrs2856966depressionHeartBrainstem neuronSerotonin Synthesis and MetabolismGq signalingK+Cell MembraneIncreased brainstem hypoplasia with SIDSGs signaling2+Putative TRPutative TRs211912356245669248971153GATA3TNFTCF35-HTCREB1IL8MAOACREBBPTLX3DDCSLC6A4VIPR1HTR2ARESTPBX1KCNQ1MEF2CSP3MIR13APKNOX15-HTADCYAP15-HTTP73TACR1ALDOANR3C1KCNH2 JUNCDCA7LC4ASSTR1HES1RORAGNB3SP1KCNQ1SCN5ANFKB1ADCYAP1RESTNicotinePPARGC1BNGFYBX1HTR1ANR3C1MIR210RETTPH25-HIAANKX3-1ESR2C4BNFYASP1HSPD1CAV3RESTTPH1SP1CC2D1ARUNX3IL6RMAOAGATA2SSTR2HES1AVPNEUROD1RESTHES5FEVRYR2IL6KCNH2LMX1BEN1HIF1AGlial Cell DifferentiationDLX2ECE1FEVSP1HADHAL-TryptophanFluoxetineBHLHE40THRBDEAF1CAV3CHRNA4CREB1HIF1AREST5-HTPDDCACADMCHRNB4PHOX2AMAZCTCFSP1EGR1IL10ASCL1RYR2ARADCYAP1R1TPH2PHOX2BFOXM1NFKB1NKX2-2POU3F2MIR16-1HTR1APPARGC1AEP300VIPR2TPH1CREB1PLP1POU3F232121124117651056649461737131123931338411896, 10467309010211049361001084526850535Putative TRsCTNNB1SOX2NANOGPOU5F15MAPK pathway95BDNFNTRK2Gi signalingGABAGABRA18358CHRM2GJA145SNTA1Na+H+14K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction55SLC9A3CASP3FMO361G6PC85GCKGPD1L25GRIN1HADHB80HTR3ASCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia925-HTGlutamateCa2+106H2OH2OAQP4ApoptosisCPT1A101IL1A6IL1BIL1RN663IL1389TSPYL1VEGFA7715SCN5A18DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP98Gq signalingMAP2TAC141MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamate41SSTTAC141HTR3ATH7682CHAT35114SLC9A3BDNFNTRK295AQP4106GRIN170SP199NFKB2JUN94HDAC9MYB73CEBPB57SNTA145GPD1LSP1JUNNR3C1REST4419JUNCREB1POU2F2CREM47RESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA183CREB181VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs12536