Sudden infant death syndrome (SIDS) susceptibility pathways (Homo sapiens)

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115189063671171710012, 52, 1097311251753452262, 1034842106804198, 1166152264, 86, 10513783554274969685854710435356271102710835271251165410454838320, 33838311111112083111119, 1201218344111120931119389838383119, 12083381202+Soma MembraneIncreased brainstem hypoplasia with SIDSSerotonin Synthesis and Metabolismrs2856966Putative TRsNucleusAssociated with Infection and SIDSC825T2OtherPutative TRsBradycardiaSarcoplasmic ReticulumHeartPutative TRsRapidly-activating K+ CurrentVagal ToneSerotonin SignalingGq signalingPutative TRCardiac myocyteCell MembraneIncreased long-QT with SIDS BrownAdiposePutative TRPutative TRTRrThermoregulationBrainstem neuronNucleusSPhMiscelaneous SIDS AssociatedSIDS associated polymorphismsGs signalingGi signalingTR: Transcriptional RegulationNHDecreased relative SIDS expressionSPhSPhPutative TRsNerve TerminalK+Putative TRIVS-191_190insAFocal AdhesionsSph: SIDS Phenotype Animal ModelG5477AIncreased relative SIDS expression Slowly-Activating K+ CurrentPutative TRsNa+4R/4RBrainSPhPutative TRCap+HNdepressionAssociated with Energy Metabolism and SIDScircadianPutative TRHOK+G2989TInfant (<1 year in age)Putative TRPutative TRsStabilizationTRrPutative TRsSleepSIDS Susceptibility PathwaysG-proteinSerotoninTransporter6455105113798464287077105DLX2PBX1NR3C1RETCHRNA4FOXM1JUNSP1TPH2DEAF1DDCPHOX2BTP73EGR1KCNQ1DDCHES1ECE1MIR13AMEF2CADCYAP1R1CREB1TCF3MIR16-1CAV3MAZESR2RUNX3ASCL1RYR2IL8KCNH2 VIPR2HES1CAV35-HTRESTCREBBPLMX1BKCNQ15-HTPCHRNB4CDCA7LHTR1AC4BRESTNFYAPLP1SP1SLC6A4RESTACADMFEVCREB1TACR1IL6C4AFEV5-HTARTPH1RYR2FluoxetineCTCFGlial Cell DifferentiationTNFSCN5AHADHAHTR1AL-TryptophanRESTNFKB1POU3F2MAOASP3SSTR1PPARGC1BTLX35-HTSP1ALDOAKCNH2BHLHE40GNB3EN1NKX3-1NR3C1PKNOX1HSPD1NKX2-2HIF1AYBX1NicotineCC2D1AVIPR15-HIAAHTR2ANFKB1NEUROD1RESTRORACREB1GATA2NGFSSTR2POU3F2TPH2MAOAEP300AVPHES5PPARGC1AMIR210SP1ADCYAP1IL6RTPH1THRBPHOX2AGATA3IL10ADCYAP1SP1HIF1A33115153588124587597986074123823930101215936, 4971524665114812788823141161Putative TRsCTNNB1SOX2NANOGPOU5F11MAPK pathway120BDNFNTRK2Gi signalingGABAGABRA116CHRM2118GJA172SNTA1Na+H+91K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivation69GAP JunctionSLC9A3CASP3FMO3G6PC5719GCKGPD1L29GRIN1HADHBHTR3A3SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia255-HTGlutamateCa2+43H2OH2OAQP4ApoptosisCPT1AIL1A95IL1B8787IL1RN24IL1356TSPYL1VEGFA99SCN5A3776DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDC9NOS1APGq signalingMAP2TAC1100MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamateSST100100TAC1HTR3ATH90CHAT184438SLC9A3BDNFNTRK2120AQP443GRIN1117SP132NFKB2JUN102HDAC9MYB2CEBPB6772SNTA1GPD1LSP1JUNNR3C1REST5310JUNCREB1POU2F2122CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRr16GABRA1CREB1107VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs11035