Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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1148851228046428112312511811132, 62, 9376510662557073, 95107281333, 117198636525826897311193663826, 25, 54828233119316041973152999731161081642161034242, 775910342, 7745, 741616103241045916103841031616161642Putative TRsHeartSIDS associated polymorphismsNerve TerminalG2989TSPhIncreased relative SIDS expressionSerotoninTransporterCell MembraneOtherTR: Transcriptional RegulationVagal TonePutative TRsPutative TRPutative TRBradycardiaGs signalingPutative TRsrs2856966Serotonin SignalingPutative TRsGq signalingHOBrainstem neuronSerotonin Synthesis and MetabolismCa2Cardiac myocytePutative TRsRapidly-activating K+ CurrentStabilizationPutative TR4R/4RGi signalingC825TcircadianIncreased brainstem hypoplasia with SIDSSPhPutative TRsK+HNG5477ATRr BrownAdiposeSoma MembraneSPhPutative TRIncreased long-QT with SIDSMiscelaneous SIDS AssociatedNucleusIVS-191_190insAPutative TRNHPutative TRFocal AdhesionsSPhSarcoplasmic ReticulumK+TRrPutative TRsBrainNucleusNa+Sph: SIDS Phenotype Animal ModelSIDS Susceptibility PathwaysThermoregulationAssociated with Energy Metabolism and SIDSG-proteinDecreased relative SIDS expressionp+2+SleepAssociated with Infection and SIDSInfant (<1 year in age)depression Slowly-Activating K+ CurrentPutative TR4669284611226179623DDCRESTNGFTPH1CREB1DDCHES1C4BSP1EN1GNB3MAOARUNX3ACADMDLX2ADCYAP1PBX1FEVSSTR2GATA2TPH1SP1CDCA7L5-HTGATA3CC2D1AYBX15-HTPPHOX2BRESTEGR1RYR2TNFAVP5-HTVIPR1ALDOACTCFSP1HSPD1MAZCREBBPIL10IL8RESTDEAF1RYR2PPARGC1BHTR1ATLX3HADHANR3C1ADCYAP1HTR1AHIF1ACHRNA4NFKB1HTR2ATPH2FluoxetineFEVPKNOX1RESTKCNQ1MIR13ANFYAIL6RMAOAC4A5-HIAAHES5EP300CREB1BHLHE40TACR1NKX2-2HES1SSTR1L-TryptophanRESTPLP1SCN5A5-HTPOU3F2NicotineHIF1AIL6SLC6A4MEF2CSP1JUNTCF3Glial Cell DifferentiationPHOX2AESR2ASCL1ECE1NFKB1KCNH2KCNH2 TPH2CREB1KCNQ1NR3C1NKX3-1FOXM1ARMIR16-1MIR210TP73CAV3ADCYAP1R1SP1LMX1BVIPR2THRBNEUROD1PPARGC1APOU3F2SP3RETRORACHRNB4CAV33311719, 116911529781510545476153983182103712110039109124113437611089146269984071Putative TRsCTNNB1SOX2NANOGPOU5F171MAPK pathway42BDNFNTRK2Gi signalingGABAGABRA1112CHRM2123GJA118SNTA1Na+H+49K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivation11GAP JunctionSLC9A3CASP3FMO3G6PC3544GCKGPD1L66GRIN1HADHBHTR3A102SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia275-HTGlutamateCa2+34H2OH2OAQP4ApoptosisCPT1AIL1A94IL1B120120IL1RN67IL1358TSPYL1VEGFA57SCN5A4830DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDC75NOS1APGq signalingMAP2TAC12MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamateSST22TAC1HTR3ATH51CHAT8810484SLC9A3BDNFNTRK242AQP434GRIN14SP1101NFKB2JUN20HDAC9MYB79CEBPB8018SNTA1GPD1LSP1JUNNR3C1REST11826JUNCREB1POU2F250CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRr112GABRA1CREB156VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs9931