Leptin and adiponectin (Mus musculus)

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1beta-oxidationMitochondrionLeptinPrkaa1Cpt1Adipor1Adipor2Prkab1Malonyl-CoAAdiponectinFatty acidLeprPrkag1Acetyl-CoAAcc1Fatty acid


Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in Dyck et al..

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Ontology Terms



  1. Dyck DJ, Heigenhauser GJ, Bruce CR; ''The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.''; Acta Physiol (Oxf), 2006 PubMed Europe PMC Scholia


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107213view14:30, 17 September 2019MaintBotChEBI identifier normalization
71946view22:18, 23 October 2013EgonwReplaced a random box with a mitochondrion drawing.
71945view22:11, 23 October 2013EgonwAdded a ChEBI id for 'fatty acid'.
69111view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
45174view08:52, 7 October 2011ThomasOntology Term : 'glucose metabolism disease' added !
45173view08:50, 7 October 2011ThomasOntology Term : 'leptin system pathway' added !
45172view08:50, 7 October 2011ThomasOntology Term : 'adiponectin signaling pathway' added !
41298view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
33406view14:48, 30 November 2009MaintBotRemoved group label
29045view12:49, 27 March 2009ThomasNew pathway

External references


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NameTypeDatabase referenceComment
Acc1GeneProduct107476 (Entrez Gene)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
AdiponectinGeneProduct11450 (Entrez Gene)
Adipor1GeneProduct72674 (Entrez Gene)
Adipor2GeneProduct68465 (Entrez Gene)
Cpt1GeneProduct12894 (Entrez Gene)
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
LeprGeneProduct16847 (Entrez Gene)
LeptinGeneProduct16846 (Entrez Gene)
Malonyl-CoAMetaboliteCHEBI:15531 (ChEBI)
Prkaa1GeneProduct105787 (Entrez Gene)
Prkab1GeneProduct19079 (Entrez Gene)
Prkag1GeneProduct19082 (Entrez Gene)

Annotated Interactions

No annotated interactions

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