FAS pathway and Stress induction of HSP regulation (Mus musculus)

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1Necrosis3x-PActivateROSStress Induction of HSP regulationCell Survival3x-PExtracellularApoptosomeCytoplasmDNA presentationApoptosisSelf-activation3x-PNucleusNFK-B PathwayFAS PathwayProteasomeInhibitionCutMitochondria PathwayStressDffaMapkapk3Rb1JunHspb1Lmnb2Casp3PhosphateMap2k4Faf1LmnaPhosphateHspb1Apaf1CeramideArhgdibCasp3Casp7Il1aDaxxDffbGlutathioneDffbMapk8PhosphateHspb1PhosphateCasp8FaddPak2Hspb1Faf1FasFaslCasp6Hspb1PrkdcCasp9TnfParp1DaxxCasp8Hspb1Mapkapk2PhosphateHspb1Hspb1CASP10Pak1Apaf1PhosphateMap3k1actinPhosphateCflarGm10108Spna2PhosphateLmnb1FAP-1Ripk2Bcl2Map3k7


This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.


This pathway was inferred from Homo sapiens pathway WP314(r21341) with a 94% conversion rate.

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Ontology Terms



  1. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia


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109410view18:17, 16 March 2020L DupuisFixed interactions
109379view15:24, 16 March 2020L DupuisConverted interactions to graphical lines
106905view13:38, 17 September 2019MaintBotHMDB identifier normalization
71736view20:17, 17 October 2013MaintBotAutomated update of data sources
69119view18:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
67223view10:23, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
47743view19:15, 5 April 2012Thomasfixed wrongly annotated gene
41305view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
38241view21:19, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38240view21:18, 27 August 2010KhanspersReverted to version '15:06, 12 February 2010' by Khanspers
38190view00:29, 24 August 2010Khanspers
35565view15:06, 12 February 2010Thomasadded literature
35560view15:01, 12 February 2010ThomasModified description
34390view22:52, 9 December 2009MaintBotAutomatic update of empty xrefs
32872view22:02, 16 September 2009MaintBotNA
32468view17:29, 15 August 2009MaintBotFixed text labels
32154view14:02, 14 August 2009MaintBotFixed group labels
31479view21:23, 13 August 2009MaintBotFixed text labels
30859view00:10, 30 July 2009MaintBotConverted from Homo sapiens
21882view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:WP571]]: Moved to stable identifier
8018view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:Mus musculus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]]: Renaming species
7632view16:06, 18 December 2007MaintBotfixed category names
7220view12:41, 4 November 2007MaintBotAdded categories to GPML
6436view22:18, 22 May 2007169.230.77.174gpml file for [[Mouse:Fas_Pathway_and_Stress_Induction_of_HSP_Regulation_Biocarta]]

External references


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NameTypeDatabase referenceComment
Apaf1GeneProduct11783 (Entrez Gene)
ArhgdibGeneProduct11857 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
Bcl2GeneProduct12043 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp6GeneProduct12368 (Entrez Gene)
Casp7GeneProduct12369 (Entrez Gene)
Casp8GeneProduct12370 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
CflarGeneProduct12633 (Entrez Gene)
DaxxGeneProduct13163 (Entrez Gene)
DffaGeneProduct13347 (Entrez Gene)
DffbGeneProduct13368 (Entrez Gene)
FAP-1GeneProduct19249 (Entrez Gene)
FaddGeneProduct14082 (Entrez Gene)
Faf1GeneProduct14084 (Entrez Gene)
FasGeneProduct14102 (Entrez Gene)
FaslGeneProduct14103 (Entrez Gene)
GlutathioneMetaboliteHMDB0000125 (HMDB)
Gm10108GeneProduct670717 (Entrez Gene)
Hspb1GeneProduct15507 (Entrez Gene)
Il1aGeneProduct16175 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
LmnaGeneProduct16905 (Entrez Gene)
Lmnb1GeneProduct16906 (Entrez Gene)
Lmnb2GeneProduct16907 (Entrez Gene)
Map2k4GeneProduct26398 (Entrez Gene)
Map3k1GeneProduct26401 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mapkapk2GeneProduct17164 (Entrez Gene)
Mapkapk3GeneProduct102626 (Entrez Gene)
Pak1GeneProduct18479 (Entrez Gene)
Pak2GeneProduct224105 (Entrez Gene)
Parp1GeneProduct11545 (Entrez Gene)
PhosphateMetaboliteHMDB0001429 (HMDB)
PrkdcGeneProduct19090 (Entrez Gene)
Rb1GeneProduct19645 (Entrez Gene)
Ripk2GeneProduct192656 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
Spna2GeneProduct20740 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TnfGeneProduct21926 (Entrez Gene)

Annotated Interactions

No annotated interactions
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