Monoamine GPCRs (Mus musculus)

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AdrenergicReceptorsGq/G11 PathwayHistamineReceptorsGi/Go PathwayMuscarinicAcetylcholine ReceptorsGs PathwayDopamineReceptorsGs PathwaySerotoninReceptorsEpinephrineChrm1Htr2aChrm2Htr1fHtr7Hrh2Chrm5Adra2aHtr6Acetylcholine Adrb3Htr1aDrd2SerotoninDrd3DopamineChrm4Adra2cDrd1aHtr1bHtr5bHtr2cNorepinephrineAdra1aAdrb1Chrm3Adrb2Htr1dDrd4Htr5aAdra1bAdra1dHistamineDrd5Htr2bAdra2bHrh1Htr4Muscarine


G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia

Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters


This pathway was inferred from Homo sapiens pathway WP58(r20799) with a 86% conversion rate.

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Ontology Terms



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106904view13:37, 17 September 2019MaintBotHMDB identifier normalization
96091view19:09, 15 February 2018KhanspersModified description
72043view13:59, 24 October 2013Mkutmonfixed unconnected lines
69197view18:23, 8 July 2013MaintBotUpdated to 2013 gpml schema
67490view11:08, 26 June 2013DdiglesOntology Term : 'G protein mediated signaling pathway' added !
60231view20:15, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
55122view17:45, 12 December 2012SravanthisinhaReverted to version '05:32, 17 May 2012' by Sravanthisinha
55121view17:43, 12 December 2012ApplecoolModified description
55120view17:40, 12 December 2012ApplecoolModified description
48232view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41388view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34427view23:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32720view23:42, 2 September 2009MaintBotadded xrefs
32467view17:29, 15 August 2009MaintBotFixed text labels
32153view14:02, 14 August 2009MaintBotFixed group labels
31478view21:23, 13 August 2009MaintBotFixed text labels
30908view00:26, 30 July 2009MaintBotConverted from Homo sapiens
21880view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Monoamine GPCRs]] moved to [[Pathway:WP570]]: Moved to stable identifier
8268view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Monoamine GPCRs]] moved to [[Pathway:Mus musculus:Monoamine GPCRs]]: Renaming species
7754view16:15, 18 December 2007MaintBotfixed category names
7432view12:42, 4 November 2007MaintBotAdded categories to GPML
19516view22:19, 22 May 2007J.S.Fonggpml file for [[Mouse:Monoamine_GPCRs]]
6477view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Monoamine_GPCRs]]

External references


View all...
NameTypeDatabase referenceComment
Acetylcholine MetaboliteHMDB0000895 (HMDB)
Adra1aGeneProduct11549 (Entrez Gene)
Adra1bGeneProduct11548 (Entrez Gene)
Adra1dGeneProduct11550 (Entrez Gene)
Adra2aGeneProduct11551 (Entrez Gene)
Adra2bGeneProduct11552 (Entrez Gene)
Adra2cGeneProduct11553 (Entrez Gene)
Adrb1GeneProduct11554 (Entrez Gene)
Adrb2GeneProduct11555 (Entrez Gene)
Adrb3GeneProduct11556 (Entrez Gene)
Chrm1GeneProduct12669 (Entrez Gene)
Chrm2GeneProduct243764 (Entrez Gene)
Chrm3GeneProduct12671 (Entrez Gene)
Chrm4GeneProduct12672 (Entrez Gene)
Chrm5GeneProduct213788 (Entrez Gene)
DopamineMetaboliteHMDB0000073 (HMDB)
Drd1aGeneProduct13488 (Entrez Gene)
Drd2GeneProduct13489 (Entrez Gene)
Drd3GeneProduct13490 (Entrez Gene)
Drd4GeneProduct13491 (Entrez Gene)
Drd5GeneProduct13492 (Entrez Gene)
EpinephrineMetaboliteHMDB0000068 (HMDB)
HistamineMetaboliteHMDB0000870 (HMDB)
Hrh1GeneProduct15465 (Entrez Gene)
Hrh2GeneProduct15466 (Entrez Gene)
Htr1aGeneProduct15550 (Entrez Gene)
Htr1bGeneProduct15551 (Entrez Gene)
Htr1dGeneProduct15552 (Entrez Gene)
Htr1fGeneProduct15557 (Entrez Gene)
Htr2aGeneProduct15558 (Entrez Gene)
Htr2bGeneProduct15559 (Entrez Gene)
Htr2cGeneProduct15560 (Entrez Gene)
Htr4GeneProduct15562 (Entrez Gene)
Htr5aGeneProduct15563 (Entrez Gene)
Htr5bGeneProduct15564 (Entrez Gene)
Htr6GeneProduct15565 (Entrez Gene)
Htr7GeneProduct15566 (Entrez Gene)
MuscarineMetabolite9308 (PubChem-compound)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
SerotoninMetaboliteHMDB0000259 (HMDB)

Annotated Interactions

No annotated interactions
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