Signal Transduction of S1P Receptor (Mus musculus)

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GPCRs similar to S1PSphk2Mapk3Edg5Akt3Racgap1Mapk12Mapk6Edg8Akt1Gnai2Pik3c2gPlcb3Gnai3Asah2Edg3Edg1Mapk1Akt2Sphk1Gnai1Mapk7Smpd2


This is a representation of figure 2 from T. Hla, et al. 2001, Science, 294, pg. 1877.

Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a bioactive lipid mediator. Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine.

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94903view21:03, 12 October 2017Khanspersconnected interaction
94819view02:51, 6 October 2017KhanspersModified description
94818view02:48, 6 October 2017Khanspersremoved old GenMAPP comments
94817view02:43, 6 October 2017Khanspersfixed interactions and updated layout
78439view10:26, 7 January 2015MaintBotadded missing graphIds
69159view18:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
67644view11:43, 26 June 2013DdiglesOntology Term : 'sphingosine 1-phosphate signaling pathway' added !
41348view00:26, 2 March 2011MaintBotRemoved redundant pathway information and comments
33389view14:44, 30 November 2009MaintBotRemoved group label
32718view23:34, 2 September 2009MaintBotAdded groups and connected
20797view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:S1P Signaling]] moved to [[Pathway:WP57]]: Moved to stable identifier
8374view13:46, 7 January 2008MaintBot[[Pathway:Mouse:S1P Signaling]] moved to [[Pathway:Mus musculus:S1P Signaling]]: Renaming species
7805view16:19, 18 December 2007MaintBotfixed category names
7293view12:41, 4 November 2007MaintBotAdded categories to GPML
6492view22:19, 22 May 2007S.Donigergpml file for [[Mouse:S1P_Signaling]]

External references


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NameTypeDatabase referenceComment
Akt1GeneProduct11651 (Entrez Gene)
Akt2GeneProduct11652 (Entrez Gene)
Akt3GeneProduct23797 (Entrez Gene)
Asah2GeneProduct54447 (Entrez Gene)
Edg1GeneProduct13609 (Entrez Gene)
Edg3GeneProduct13610 (Entrez Gene)
Edg5GeneProduct14739 (Entrez Gene)
Edg8GeneProduct94226 (Entrez Gene)
Gnai1GeneProduct14677 (Entrez Gene)
Gnai2GeneProduct14678 (Entrez Gene)
Gnai3GeneProduct14679 (Entrez Gene)
Mapk12GeneProduct29857 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk6GeneProduct50772 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Pik3c2gGeneProduct18705 (Entrez Gene)
Plcb3GeneProduct18797 (Entrez Gene)
Racgap1GeneProduct26934 (Entrez Gene)
Smpd2GeneProduct20598 (Entrez Gene)
Sphk1GeneProduct20698 (Entrez Gene)
Sphk2GeneProduct56632 (Entrez Gene)

Annotated Interactions

No annotated interactions

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