DNA Replication (Drosophila melanogaster)

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1, 2Orc complexwith the replication forkMcm 4,6,7 trimer forms and associatesCdt1ATPRFC140ADPMcm7Orc3Orc4Cdc6Mcm6Orc3Cdt1ATPCdc6Mcm2GemininRNA primer-DNA primer:origin duplex:PCNACdt1p584. Switching of origins to post-replicative stateDegraded by proteasome in cytosolCdc6ATPMcm7Cdt15. Leading/lagging strand synthesisRFC Heteropentamer:RNA primer-DNA primer3. DNA replication initiationADPCdc6RFC37UbiquitinPhosphorylated Orc1p180Orc4RNA PrimerOrc5ATPOrc2CTPOrc5Mcm5Orc ComplexPCNA homotrimerOrc2dATPMcm3RFC36Orc5Degraded by proteasome in cytosoldCTPdUTPOrc complexOrc2DNA polymerase alpha: primase: origin complexUbiquitinated Cdc6Orc complexRNA primer-DNA primerMcm4Orc3dGTPp49Orc1p70Mcm6aGTPUbiquitinated Orc1Orc3Mcm3RFC Heteropentamer:RNA primer-DNA primer:1. Assembly of the pre-replicative complexDNA PolymeraseCdt1Mcm4RNA primer-DNA primerDNA polymerase alpha: primase: origin complexOrc complexPhosphorylation of Mcm 2-7 complexRFC38RFC40Mcm5Mcm2UTPPre-replicative complexOriginPhosphorylated Cdc6PrimaseMcm10Pre-replicative complexUbiquitinProcessive complex2. Activation of the pre-replicative complexOrc2Orc4POLD3CG9273RfC3DNApol-alpha73Mcm10CG12018Ubi-p63EdpaRpL40Orc6CG5971DNApol-alpha50DNApol-deltaGnf1Orc1ASKGMNNCG8142Mcm6DNApol-epsilonOrc5RfC38RPA4Mcm5RfC40latRpA-70mus209l(1)G0148CDK2Mcm2DNAprimRPA3Orc2dupMcm7DNApol-alpha180POLD4Pole2CDC45LMcm3


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ASKGeneProduct
ATPMetabolite
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
CTPMetabolite
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
GTPMetabolite
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
UTPMetabolite
Ubi-p63EGeneProduct38456 (Entrez Gene)
UbiquitinMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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