TGF-beta Receptor Signaling (Homo sapiens)

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1, 23CofactorAccessory receptorCofactorsCo-SmadsRepressorsLigandsCo-smadsDNARsmadsR-SmadsSMAD5TGFBR1EP300CREBBPSKISMAD6SKILRUNX3TGIFLIFSMAD1MAPK3SMAD3BMP4TGFBR1HRASMAPK9JUNBAMBIFSTNFKB1SMAD1TFE3TGFBR2TNFLEF1STAT3BMP4ZNF423TGFBR2ITGB6TGFB1FOSNOGTGFB1SMAD4THBS1SMAD2IFNGJAK1SMAD7SMAD9FOXH1ENGRUNX2CTNNB1TNFZFYVE9SPP1SMAD2LTBP1ZFHX1BINHBAEGFSTAT1TGFBR3FKBP1AMIR302ASERPINE1WNT1LEFTY1LEFTY23


Description

The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.

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Ontology Terms

 

Bibliography

  1. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed
  2. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed
  3. Ivey KN, Srivastava D; ''MicroRNAs as regulators of differentiation and cell fate decisions.''; Cell Stem Cell, 2010 PubMed

History

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CompareRevisionActionTimeUserComment
94936view16:30, 15 October 2017Khanspersremoved unconnected anchor
94820view02:53, 6 October 2017Khanspersconnected interactions
90187view19:45, 21 October 2016Khanspersfixed unconnected
86085view20:48, 29 June 2016AlexanderPicoRemoved extraneous comment from legacy version
83868view00:52, 18 December 2015AlexanderPicoModified title
68944view17:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
59137view22:37, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
45086view20:56, 6 October 2011KhanspersOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
42992view18:28, 25 May 2011Samuel SklarLitref added
42596view21:38, 7 April 2011Samuel SklarSpecify description
42595view21:25, 7 April 2011Samuel SklarSpecify description
42594view21:08, 7 April 2011Samuel SklarPeriodical save, work in progress
41094view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
38767view23:29, 23 September 2010AlexanderPico
38766view23:28, 23 September 2010AlexanderPicoSpecify description
38765view23:24, 23 September 2010AlexanderPicobeautification
32150view14:01, 14 August 2009MaintBotFixed group labels
30273view20:30, 25 July 2009AlexanderPicofixed unsupported characters in bibliography
21858view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:TGF Beta Signaling Pathway]] moved to [[Pathway:WP560]]: Moved to stable identifier
14923view15:10, 24 May 2008MartijnVanIerselPeriodical save, work in progress
13022view11:07, 17 May 2008MaintBotSticky edges patch by Sjoerd
11728view20:24, 23 April 2008AlexanderPicoModified description
11726view20:23, 23 April 2008AlexanderPicoModified description
11720view15:33, 23 April 2008Thomastransfered references in GenMAPP comment to literature references
11718view15:29, 23 April 2008ThomasModified description
8440view13:46, 7 January 2008MaintBot[[Pathway:Human:TGF Beta Signaling Pathway]] moved to [[Pathway:Homo sapiens:TGF Beta Signaling Pathway]]: Renaming species
7836view16:21, 18 December 2007MaintBotfixed category names
7301view12:42, 4 November 2007MaintBotAdded categories to GPML
6398view22:18, 22 May 2007N.Galgpml file for [[Human:TGF_Beta_Signaling_Pathway]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BAMBIGeneProduct25805 (Entrez Gene)
BMP4GeneProduct652 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
ENGGeneProduct2022 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
FKBP1AGeneProduct2280 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOXH1GeneProduct8928 (Entrez Gene)
FSTGeneProduct10468 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
INHBAGeneProduct3624 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
LEFTY1GeneProduct10637 (Entrez Gene)
LEFTY2GeneProduct7044 (Entrez Gene)
LIFGeneProduct3976 (Entrez Gene)
LTBP1GeneProduct4052 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MIR302AGeneProductENSG00000207927 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene)
NOGGeneProduct9241 (Entrez Gene)
RUNX2GeneProduct860 (Entrez Gene)
RUNX3GeneProduct864 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SKIGeneProduct6497 (Entrez Gene)
SKILGeneProduct6498 (Entrez Gene)
SMAD1GeneProduct4086 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SMAD5GeneProduct4090 (Entrez Gene)
SMAD6GeneProduct4091 (Entrez Gene)
SMAD7GeneProduct4092 (Entrez Gene)
SMAD9GeneProduct4093 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TFE3GeneProduct7030 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFBR1GeneProduct7046 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TGFBR3GeneProduct7049 (Entrez Gene)
TGIFGeneProduct7050 (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene) there are 5 types of tsp
TNFGeneProduct7124 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
ZFHX1BGeneProduct9839 (Entrez Gene)
ZFYVE9GeneProduct9372 (Entrez Gene)
ZNF423GeneProduct23090 (Entrez Gene)

Annotated Interactions

No annotated interactions

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