TGF-beta receptor signaling (Homo sapiens)

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The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia).

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC Scholia
  2. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  3. Ivey KN, Srivastava D; ''MicroRNAs as regulators of differentiation and cell fate decisions.''; Cell Stem Cell, 2010 PubMed Europe PMC Scholia


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117838view15:12, 22 May 2021EweitzModified title
106477view19:42, 3 September 2019KhanspersModified description
105453view05:03, 8 August 2019KhanspersModified description
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105451view05:01, 8 August 2019KhanspersModified description
104852view14:52, 20 June 2019IreneHemelRemoved unconnected line behind a node
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90187view19:45, 21 October 2016Khanspersfixed unconnected
86085view20:48, 29 June 2016AlexanderPicoRemoved extraneous comment from legacy version
83868view00:52, 18 December 2015AlexanderPicoModified title
68944view17:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
59137view22:37, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
45086view20:56, 6 October 2011KhanspersOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
42992view18:28, 25 May 2011Samuel SklarLitref added
42596view21:38, 7 April 2011Samuel SklarSpecify description
42595view21:25, 7 April 2011Samuel SklarSpecify description
42594view21:08, 7 April 2011Samuel SklarPeriodical save, work in progress
41094view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
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38765view23:24, 23 September 2010AlexanderPicobeautification
32150view14:01, 14 August 2009MaintBotFixed group labels
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21858view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:TGF Beta Signaling Pathway]] moved to [[Pathway:WP560]]: Moved to stable identifier
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11718view15:29, 23 April 2008ThomasModified description
8440view13:46, 7 January 2008MaintBot[[Pathway:Human:TGF Beta Signaling Pathway]] moved to [[Pathway:Homo sapiens:TGF Beta Signaling Pathway]]: Renaming species
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External references


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NameTypeDatabase referenceComment
BAMBIGeneProduct25805 (Entrez Gene)
BMP4GeneProduct652 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
ENGGeneProduct2022 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
FKBP1AGeneProduct2280 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOXH1GeneProduct8928 (Entrez Gene)
FSTGeneProduct10468 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
INHBAGeneProduct3624 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
LEFTY1GeneProduct10637 (Entrez Gene)
LEFTY2GeneProduct7044 (Entrez Gene)
LIFGeneProduct3976 (Entrez Gene)
LTBP1GeneProduct4052 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MIR302AGeneProductENSG00000207927 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene)
NOGGeneProduct9241 (Entrez Gene)
RUNX2GeneProduct860 (Entrez Gene)
RUNX3GeneProduct864 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SKIGeneProduct6497 (Entrez Gene)
SKILGeneProduct6498 (Entrez Gene)
SMAD1GeneProduct4086 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SMAD5GeneProduct4090 (Entrez Gene)
SMAD6GeneProduct4091 (Entrez Gene)
SMAD7GeneProduct4092 (Entrez Gene)
SMAD9GeneProduct4093 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TFE3GeneProduct7030 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFBR1GeneProduct7046 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TGFBR3GeneProduct7049 (Entrez Gene)
TGIFGeneProduct7050 (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene) there are 5 types of tsp
TNFGeneProduct7124 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
ZFHX1BGeneProduct9839 (Entrez Gene)
ZFYVE9GeneProduct9372 (Entrez Gene)
ZNF423GeneProduct23090 (Entrez Gene)

Annotated Interactions

No annotated interactions

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