Biogenic Amine Synthesis (Homo sapiens)

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1Synthesis pathways for biogenic aminesfollow solid arrows through enzymatic steps,while degradation steps follow dashed arrows.GAD1GAD2PNMTMelatoninSerotoninCHATL-DOPANorepinephrineHistidineTryptophanAcetylserotoninPAHMAOAAANATTPH1ASMTPhenylalanineHistamineTHAcetylcholineMAOAHDCEpinephrineDopamineDDCCOMTDDCDBHDDCACHEGABA5-hydroxy-tryptophanCholineTyrosineGlutamate


Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Purves, Dale, Augustine, George J., Fitzpatrick, David, Katz, Lawrence C., LaMantia, Anthony-Samuel, McNamara, James O., Williams, S. Mark.; ''Neuroscience'';, 2001


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106312view17:48, 20 August 2019KhanspersModified description
106192view12:08, 16 August 2019MaintBotHMDB identifier normalization
105543view06:07, 9 August 2019KhanspersModified description
102524view19:31, 3 January 2019Khanspersremoved GenMAPP comments
90171view14:34, 20 October 2016Mkutmonfix unconnected lines
89535view11:06, 16 September 2016Mkutmonontology tag fix
89472view13:39, 15 September 2016Mkutmonremove space from ontology term id
85678view02:12, 5 June 2016AlexanderPicoReverted to version '08:01, 4 August 2015' by AlexanderPico
85571view15:47, 1 June 2016AAR&CoQuick edit to datanode annotation or property
81207view15:01, 4 August 2015Eveloadded degradation endpoints
81168view12:31, 30 July 2015EveloPeriodical save, work in progress
73391view17:06, 25 January 2014EgonwFixed the layout of the CAS identifier.
67088view10:04, 26 June 2013Christine ChichesterOntology Term : 'biogenic amine biosynthetic pathway' added !
63146view20:12, 8 May 2013MaintBotUpdating GPML version
44978view14:25, 6 October 2011MartijnVanIerselOntology Term : 'amine neurotransmitter metabolic pathway' added !
41049view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
38952view00:15, 25 September 2010KhanspersChanged line types and layout
38951view00:08, 25 September 2010Khanspers
35157view14:34, 11 February 2010Thomasadded reference
35156view14:28, 11 February 2010ThomasModified description
34443view18:19, 10 December 2009MaintBotAutomatic update of empty xrefs
32463view17:27, 15 August 2009MaintBotFixed text labels
32146view14:00, 14 August 2009MaintBotFixed group labels
21838view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Biogenic Amine Synthesis]] moved to [[Pathway:WP550]]: Moved to stable identifier
15389view22:23, 27 May 2008Khanspersconnectors
14397view19:47, 22 May 2008KhanspersConnectors, changed legend
14395view19:46, 22 May 2008KhanspersAdded connectors
14393view19:31, 22 May 2008KhanspersPeriodical save, work in progress
13040view11:11, 17 May 2008MaintBotautomated metabolite conversion
7920view13:46, 7 January 2008MaintBot[[Pathway:Human:Biogenic Amine Synthesis]] moved to [[Pathway:Homo sapiens:Biogenic Amine Synthesis]]: Renaming species
7585view16:02, 18 December 2007MaintBotfixed category names
7331view12:42, 4 November 2007MaintBotAdded categories to GPML
6297view22:17, 22 May 2007AlexanderPicogpml file for [[Human:Biogenic_Amine_Synthesis]]

External references


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NameTypeDatabase referenceComment
5-hydroxy-tryptophanMetabolite4350-09-8 (CAS)
AANATGeneProduct15 (Entrez Gene)
ACHEGeneProduct43 (Entrez Gene)
ASMTGeneProduct438 (Entrez Gene)
AcetylcholineMetabolite51-84-3 (CAS)
AcetylserotoninMetabolite1210-83-9 (CAS)
CHATGeneProduct1103 (Entrez Gene)
COMTGeneProduct1312 (Entrez Gene)
CholineMetabolite62-49-7 (CAS)
DBHGeneProduct1621 (Entrez Gene)
DDCGeneProduct1644 (Entrez Gene)
DopamineMetabolite62-31-7 (CAS)
EpinephrineMetaboliteHMDB0000068 (HMDB)
GABAMetaboliteHMDB0000112 (HMDB)
GAD1GeneProduct2571 (Entrez Gene)
GAD2GeneProduct2572 (Entrez Gene)
GlutamateMetabolite56-86-0 (CAS)
HDCGeneProduct3067 (Entrez Gene)
HistamineMetabolite51-45-6 (CAS)
HistidineMetabolite71-00-1 (CAS)
L-DOPAMetabolite59-92-7 (CAS)
MAOAGeneProduct4128 (Entrez Gene)
MelatoninMetaboliteHMDB0001389 (HMDB)
NorepinephrineMetabolite51-41-2 (CAS)
PAHGeneProduct5053 (Entrez Gene)
PNMTGeneProduct5409 (Entrez Gene)
PhenylalanineMetabolite63-91-2 (CAS)
SerotoninMetabolite50-67-9 (CAS)
THGeneProduct7054 (Entrez Gene)
TPH1GeneProduct7166 (Entrez Gene)
TryptophanMetabolite73-22-3 (CAS)
TyrosineMetabolite60-18-4 (CAS)

Annotated Interactions

No annotated interactions

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