Biogenic Amine Synthesis (Homo sapiens)

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1Synthesis pathways for biogenic aminesfollow solid arrows through enzymatic steps,while degradation steps follow dashed arrows.GAD1GAD2PNMTMelatoninSerotoninCHATL-DOPANorepinephrineHistidineTryptophanAcetylserotoninPAHMAOAAANATTPH1ASMTPhenylalanineHistamineTHAcetylcholineMAOAHDCEpinephrineDopamineDDCCOMTDDCDBHDDCACHEGABA5-hydroxy-tryptophanCholineTyrosineGlutamate


Description

Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine.

Source: http://www.whatislife.com/reader2/Metabolism/pathway/Neurotransmitter.html

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Purves, Dale, Augustine, George J., Fitzpatrick, David, Katz, Lawrence C., LaMantia, Anthony-Samuel, McNamara, James O., Williams, S. Mark.; ''Neuroscience''; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=neurosci&part=A405, 2001

History

View all...
CompareRevisionActionTimeUserComment
106312view17:48, 20 August 2019KhanspersModified description
106192view12:08, 16 August 2019MaintBotHMDB identifier normalization
105543view06:07, 9 August 2019KhanspersModified description
102524view19:31, 3 January 2019Khanspersremoved GenMAPP comments
90171view14:34, 20 October 2016Mkutmonfix unconnected lines
89535view11:06, 16 September 2016Mkutmonontology tag fix
89472view13:39, 15 September 2016Mkutmonremove space from ontology term id
85678view02:12, 5 June 2016AlexanderPicoReverted to version '08:01, 4 August 2015' by AlexanderPico
85571view15:47, 1 June 2016AAR&CoQuick edit to datanode annotation or property
81207view15:01, 4 August 2015Eveloadded degradation endpoints
81168view12:31, 30 July 2015EveloPeriodical save, work in progress
73391view17:06, 25 January 2014EgonwFixed the layout of the CAS identifier.
67088view10:04, 26 June 2013Christine ChichesterOntology Term : 'biogenic amine biosynthetic pathway' added !
63146view20:12, 8 May 2013MaintBotUpdating GPML version
44978view14:25, 6 October 2011MartijnVanIerselOntology Term : 'amine neurotransmitter metabolic pathway' added !
41049view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
38952view00:15, 25 September 2010KhanspersChanged line types and layout
38951view00:08, 25 September 2010Khanspers
35157view14:34, 11 February 2010Thomasadded reference
35156view14:28, 11 February 2010ThomasModified description
34443view18:19, 10 December 2009MaintBotAutomatic update of empty xrefs
32463view17:27, 15 August 2009MaintBotFixed text labels
32146view14:00, 14 August 2009MaintBotFixed group labels
21838view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Biogenic Amine Synthesis]] moved to [[Pathway:WP550]]: Moved to stable identifier
15389view22:23, 27 May 2008Khanspersconnectors
14397view19:47, 22 May 2008KhanspersConnectors, changed legend
14395view19:46, 22 May 2008KhanspersAdded connectors
14393view19:31, 22 May 2008KhanspersPeriodical save, work in progress
13040view11:11, 17 May 2008MaintBotautomated metabolite conversion
7920view13:46, 7 January 2008MaintBot[[Pathway:Human:Biogenic Amine Synthesis]] moved to [[Pathway:Homo sapiens:Biogenic Amine Synthesis]]: Renaming species
7585view16:02, 18 December 2007MaintBotfixed category names
7331view12:42, 4 November 2007MaintBotAdded categories to GPML
6297view22:17, 22 May 2007AlexanderPicogpml file for [[Human:Biogenic_Amine_Synthesis]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5-hydroxy-tryptophanMetabolite4350-09-8 (CAS)
AANATGeneProduct15 (Entrez Gene)
ACHEGeneProduct43 (Entrez Gene)
ASMTGeneProduct438 (Entrez Gene)
AcetylcholineMetabolite51-84-3 (CAS)
AcetylserotoninMetabolite1210-83-9 (CAS)
CHATGeneProduct1103 (Entrez Gene)
COMTGeneProduct1312 (Entrez Gene)
CholineMetabolite62-49-7 (CAS)
DBHGeneProduct1621 (Entrez Gene)
DDCGeneProduct1644 (Entrez Gene)
DopamineMetabolite62-31-7 (CAS)
EpinephrineMetaboliteHMDB0000068 (HMDB)
GABAMetaboliteHMDB0000112 (HMDB)
GAD1GeneProduct2571 (Entrez Gene)
GAD2GeneProduct2572 (Entrez Gene)
GlutamateMetabolite56-86-0 (CAS)
HDCGeneProduct3067 (Entrez Gene)
HistamineMetabolite51-45-6 (CAS)
HistidineMetabolite71-00-1 (CAS)
L-DOPAMetabolite59-92-7 (CAS)
MAOAGeneProduct4128 (Entrez Gene)
MelatoninMetaboliteHMDB0001389 (HMDB)
NorepinephrineMetabolite51-41-2 (CAS)
PAHGeneProduct5053 (Entrez Gene)
PNMTGeneProduct5409 (Entrez Gene)
PhenylalanineMetabolite63-91-2 (CAS)
SerotoninMetabolite50-67-9 (CAS)
THGeneProduct7054 (Entrez Gene)
TPH1GeneProduct7166 (Entrez Gene)
TryptophanMetabolite73-22-3 (CAS)
TyrosineMetabolite60-18-4 (CAS)

Annotated Interactions

No annotated interactions

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