Synthesis and Degradation of Ketone Bodies (Mus musculus)

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1Pyruvate metabolismFatty acid metabolismGlycolysisSterol biosynthesis(HMG-CoA cycle)Fatty acid beta-oxidation* pathway-regulated enzymes: HMG-CoA synthase, mtHmgcs23-Hydroxy-3-methylglutaryl-CoAAcetoacetate3-Hydroxy-butyrateBdh1Acat1Acetoacetyl-CoAOxct1Acetyl-CoAAcetyl-CoAHmgcl


Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP311(r21335) with a 55% conversion rate.

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Ontology Terms



  1. Fukao T, Lopaschuk GD, Mitchell GA; ''Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.''; Prostaglandins Leukot Essent Fatty Acids, 2004 PubMed Europe PMC Scholia


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91902view20:58, 3 April 2017Khanspersremoved GenMAPP comments
70481view10:18, 7 August 2013EgonwGive the other Acetyl-CoA the same CAS id as the first.
70040view02:13, 12 July 2013AlexanderPicoAdded metabolite xrefs
70039view02:11, 12 July 2013AlexanderPicoFixed interactions
69191view18:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
67678view11:48, 26 June 2013DdiglesOntology Term : 'ketone bodies metabolic pathway' added !
48252view21:38, 17 May 2012KhanspersUpdating PubChem xrefs
48226view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
42734view22:42, 24 April 2011MaintBotfixed null db refs
41382view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
35390view09:35, 12 February 2010Thomasfixed connections
35358view09:08, 12 February 2010ThomasModified description
35356view09:08, 12 February 2010Thomasadded literature
34422view23:18, 9 December 2009MaintBotAutomatic update of empty xrefs
30856view00:09, 30 July 2009MaintBotConverted from Homo sapiens
21822view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:WP543]]: Moved to stable identifier
8422view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:Mus musculus:Synthesis and Degradation of Ketone Bodies KEGG]]: Renaming species
7828view16:20, 18 December 2007MaintBotfixed category names
7402view12:42, 4 November 2007MaintBotAdded categories to GPML
6499view22:19, 22 May 2007N.Reyesgpml file for [[Mouse:Synthesis_and_Degradation_of_Ketone_Bodies_KEGG]]

External references


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NameTypeDatabase referenceComment
3-Hydroxy-3-methylglutaryl-CoAMetabolite1553-55-5 (CAS)
3-Hydroxy-butyrateMetabolite441 (PubChem-compound)
Acat1GeneProduct110446 (Entrez Gene)
AcetoacetateMetabolite6971017 (PubChem-compound)
Acetoacetyl-CoAMetabolite1420-36-6 (CAS)
Acetyl-CoAMetabolite72-89-9 (CAS)
Bdh1GeneProduct71911 (Entrez Gene)
HmgclGeneProduct15356 (Entrez Gene)
Hmgcs2GeneProduct15360 (Entrez Gene)
Oxct1GeneProduct67041 (Entrez Gene)

Annotated Interactions

No annotated interactions
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