Glycolysis and Gluconeogenesis (Homo sapiens)

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1GlycolysisGluconeogenesisCytosolMitochondrionENO1GOT1SLC2A2ALDOCENO2LDHAPDHBG6PCMDH2PKLRPDHXPCK1PFKPGlucoseDihydroxyacetone-PPGAM1TPI1SLC2A4PFKLENO3DLD3P-GlycerateTriglyceride synthesisHK1LDHAL6BMPC1FBP1AspartateHK2Fructose 6PFructose-1,6BP1,3BP-GlycerateOxaloacetateSLC2A5ALDOAAspartatePyruvateGCKSLC2A3LDHBPKM2HK3PGAM2GAPDHMalate2P-GlycerateDLATPFKMSLC2A1PCMDH1Acetyl-CoALactatePDHA1LDHCFBP2Pentose Phosphate PathwayMPC2PKM2PyruvateGlucose-6PPDHA2GAPDHSGlycogen metabolismTCA CycleOxaloacetateGOT2GlucoseMalateP-enolpyruvateGlyceraldehyde 3PPGK1PGK2ALDOBGlucose-6P (open)PGIFructose 6P (open)GPI


Description

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the ATP and NADH.

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids.

Description adapted from Wikipedia.

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Ontology Terms

 

Bibliography

  1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed

History

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CompareRevisionActionTimeUserComment
98729view23:28, 2 October 2018Khanspersupdated complexes
98722view18:52, 1 October 2018KhanspersReverted to version '23:57, 11 March 2018' by Khanspers
97388view04:42, 14 May 2018Khansperscleanup
97264view03:45, 7 May 2018Ambar21pathway upload
96385view23:57, 11 March 2018MarkAHershbergerModified title
94762view15:51, 5 October 2017EgonwTagged interactions with mim-types.
93722view14:48, 14 August 2017DeSlAdded nodes for open/closed forms of glucoses; changed IDs to (2-) forms where needed.
90450view21:05, 16 November 2016KhanspersReverted to version '06:22, 10 September 2016' by Khanspers
90290view22:57, 2 November 2016MirkoBaranziniSpecify description
90289view22:55, 2 November 2016MirkoBaranziniPeriodical save, work in progress
90268view06:39, 28 October 2016MirkoBaranziniSpecify description
90267view06:37, 28 October 2016MirkoBaranziniSpecify description
90256view08:48, 27 October 2016MirkoBaranziniPeriodical save, work in progress
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90230view10:56, 26 October 2016MirkoBaranziniGlicolisi 1
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90214view09:04, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90213view09:03, 26 October 2016MirkoBaranziniglico 1
90212view08:54, 26 October 2016MirkoBaranziniPeriodical save, work in progress
90211view08:44, 26 October 2016MirkoBaranziniPeriodical save, work in progress
89372view06:22, 10 September 2016EgonwConverted to interactions to graphical lines in the legend.
78585view14:50, 7 January 2015MaintBotadded missing graphIds
74524view21:59, 28 April 2014KhanspersModified description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,3BP-GlycerateMetaboliteHMDB01270 (HMDB)
2P-GlycerateMetaboliteHMDB00362 (HMDB)
3P-GlycerateMetaboliteHMDB00807 (HMDB)
ALDOAGeneProduct226 (Entrez Gene)
ALDOBGeneProduct229 (Entrez Gene)
ALDOCGeneProduct230 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
AspartateMetaboliteHMDB00191 (HMDB)
DLATGeneProduct1737 (Entrez Gene)
DLDGeneProduct1738 (Entrez Gene)
Dihydroxyacetone-PMetaboliteHMDB01473 (HMDB)
ENO1GeneProduct2023 (Entrez Gene)
ENO2GeneProduct2026 (Entrez Gene)
ENO3GeneProduct2027 (Entrez Gene)
FBP1GeneProduct2203 (Entrez Gene)
FBP2GeneProduct8789 (Entrez Gene)
Fructose 6P (open)MetaboliteCHEBI:57579 (ChEBI) fructose-6-phosphate (2-) open form
Fructose 6PMetabolite61527 (ChEBI)
Fructose-1,6BPMetaboliteHMDB01058 (HMDB)
G6PCGeneProduct2538 (Entrez Gene) Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway
GAPDHGeneProductENSG00000111640 (Ensembl)
GAPDHSGeneProduct26330 (Entrez Gene)
GCKGeneProduct2645 (Entrez Gene) Gck is mainly active in liver
GOT1GeneProduct2805 (Entrez Gene)
GOT2GeneProduct2806 (Entrez Gene)
GPIGeneProduct2821 (Entrez Gene) glucose-6-phosphate isomerase
Glucose-6P (open)MetaboliteCHEBI:57584 (ChEBI) D-Glucose-6-Phosphate (2-) open form
Glucose-6PMetaboliteCHEBI:75052 (ChEBI) Glucose-6-Phosphate (2-)
GlucoseMetaboliteHMDB00122 (HMDB)
Glyceraldehyde 3PMetaboliteHMDB01112 (HMDB)
Glycogen metabolismPathwayWP500 (WikiPathways)
HK1GeneProduct3098 (Entrez Gene)
HK2GeneProduct3099 (Entrez Gene)
HK3GeneProduct3101 (Entrez Gene)
LDHAGeneProduct3939 (Entrez Gene)
LDHAL6BGeneProduct92483 (Entrez Gene)
LDHBGeneProduct3945 (Entrez Gene)
LDHCGeneProduct3948 (Entrez Gene)
LactateMetaboliteHMDB00190 (HMDB)
MDH1GeneProduct4190 (Entrez Gene)
MDH2GeneProduct4191 (Entrez Gene)
MPC1GeneProduct51660 (Entrez Gene)
MPC2GeneProduct25874 (Entrez Gene)
MalateMetaboliteHMDB00744 (HMDB)
OxaloacetateMetaboliteHMDB00223 (HMDB)
P-enolpyruvateMetaboliteHMDB00263 (HMDB)
PCGeneProduct5091 (Entrez Gene)
PCK1GeneProduct5105 (Entrez Gene)
PDHA1GeneProduct5160 (Entrez Gene)
PDHA2GeneProduct5161 (Entrez Gene)
PDHBGeneProduct5162 (Entrez Gene)
PDHXGeneProduct8050 (Entrez Gene)
PFKLGeneProduct5211 (Entrez Gene)
PFKMGeneProduct5213 (Entrez Gene)
PFKPGeneProduct5214 (Entrez Gene)
PGAM1GeneProduct5223 (Entrez Gene)
PGAM2GeneProduct5224 (Entrez Gene)
PGIGeneProduct5.3.1.9 (Enzyme Nomenclature) phosphoglucose isomerase (PGI)
PGK1GeneProduct5230 (Entrez Gene)
PGK2GeneProduct5232 (Entrez Gene)
PKLRGeneProduct5313 (Entrez Gene)
PKM2GeneProduct5315 (Entrez Gene)
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
PyruvateMetaboliteHMDB00243 (HMDB)
SLC2A1GeneProduct6513 (Entrez Gene)
SLC2A2GeneProduct6514 (Entrez Gene)
SLC2A3GeneProduct6515 (Entrez Gene)
SLC2A4GeneProduct6517 (Entrez Gene)
SLC2A5GeneProduct6518 (Entrez Gene)
TCA CyclePathwayWP78 (WikiPathways)
TPI1GeneProduct7167 (Entrez Gene)
Triglyceride synthesisPathwayWP325 (WikiPathways)

Annotated Interactions

No annotated interactions

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