Biogenic Amine Synthesis (Mus musculus)

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1Synthesis pathways for biogenic aminesfollow solid arrows through enzymatic steps,while degradation steps follow dashed arrows.DbhComt1MelatoninDopamineGad1PahTph1SerotoninAanatAchePhenylalanineL-DopaChatCholine5-Hydroxy-tryptophanTyrosineDdcGlutamateDdcMaoaPnmtGABANorepinephrineAcetylserotoninAcetylcholineThMaoaHistidineASMTHdcDdcHistamineGad2EpinephrineTryptophan


Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine. Source:


This pathway was inferred from Homo sapiens pathway WP550(r21838) with a 53% conversion rate.

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Ontology Terms



  1. Purves, Dale, Augustine, George J., Fitzpatrick, David, Katz, Lawrence C., LaMantia, Anthony-Samuel, McNamara, James O., Williams, S. Mark.; ''Neuroscience'';, 2001


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106900view13:37, 17 September 2019MaintBotHMDB identifier normalization
89981view18:55, 6 October 2016Mkutmonfixed unconnected lines
89533view11:05, 16 September 2016Mkutmonontology tag fix
89478view13:39, 15 September 2016Mkutmonremove space from ontology term id
69135view18:15, 8 July 2013MaintBotUpdated to 2013 gpml schema
67087view10:04, 26 June 2013Christine ChichesterOntology Term : 'biogenic amine biosynthetic pathway' added !
41322view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
35167view14:45, 11 February 2010ThomasModified description
35166view14:44, 11 February 2010Thomasadded literature
34397view22:56, 9 December 2009MaintBotAutomatic update of empty xrefs
32839view19:51, 14 September 2009MaintBotadded xrefs
32838view19:47, 14 September 2009MaintBotPeriodical save, work in progress
32454view17:23, 15 August 2009MaintBotFixed text labels
32136view13:56, 14 August 2009MaintBotFixed group labels
31472view21:20, 13 August 2009MaintBotFixed text labels
30842view00:04, 30 July 2009MaintBotConverted from Homo sapiens
21776view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Biogenic Amine Synthesis]] moved to [[Pathway:WP522]]: Moved to stable identifier
7922view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Biogenic Amine Synthesis]] moved to [[Pathway:Mus musculus:Biogenic Amine Synthesis]]: Renaming species
7586view16:02, 18 December 2007MaintBotfixed category names
7332view12:42, 4 November 2007MaintBotAdded categories to GPML
6417view22:18, 22 May 2007AlexanderPicogpml file for [[Mouse:Biogenic_Amine_Synthesis]]

External references


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NameTypeDatabase referenceComment
5-Hydroxy-tryptophanMetaboliteHMDB0000472 (HMDB)
ASMTGeneProduct107626 (Entrez Gene)
AanatGeneProduct11298 (Entrez Gene)
AcetylcholineMetaboliteHMDB0000895 (HMDB)
AcetylserotoninMetaboliteHMDB0001238 (HMDB)
AcheGeneProduct11423 (Entrez Gene)
ChatGeneProduct12647 (Entrez Gene)
CholineMetaboliteHMDB0000097 (HMDB)
Comt1GeneProduct12846 (Entrez Gene)
DbhGeneProduct13166 (Entrez Gene)
DdcGeneProduct13195 (Entrez Gene)
DopamineMetaboliteHMDB0000073 (HMDB)
EpinephrineMetaboliteHMDB0000068 (HMDB)
GABAMetaboliteHMDB0000112 (HMDB)
Gad1GeneProduct14415 (Entrez Gene)
Gad2GeneProduct14417 (Entrez Gene)
GlutamateMetaboliteHMDB0003339 (HMDB)
HdcGeneProduct15186 (Entrez Gene)
HistamineMetaboliteHMDB0000870 (HMDB)
HistidineMetaboliteHMDB0000177 (HMDB)
L-DopaMetaboliteHMDB0000181 (HMDB)
MaoaGeneProduct17161 (Entrez Gene)
MelatoninMetaboliteHMDB0001389 (HMDB)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
PahGeneProduct18478 (Entrez Gene)
PhenylalanineMetaboliteHMDB0000159 (HMDB)
PnmtGeneProduct18948 (Entrez Gene)
SerotoninMetaboliteHMDB0000259 (HMDB)
ThGeneProduct21823 (Entrez Gene)
Tph1GeneProduct21990 (Entrez Gene)
TryptophanMetaboliteHMDB0000929 (HMDB)
TyrosineMetaboliteHMDB0000158 (HMDB)

Annotated Interactions

No annotated interactions
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