Regulation of Actin Cytoskeleton (Homo sapiens)

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1-7+pFocal complexassemblyRTKActin polymerizationActomyosinassembly contractionChemotatic factorPI3KRASstress fiberGPCRRTKGrowth Factor (GF)Gene ExpressionActin polymerizationFocal adhesionassemblyGFPI3KStabilizationof actinGPCRFilipodiaLamellipodia?Chemotactic factorRAS-pActin polymerizationstress fiberMAPK4PAK1TMSB4XCRKFGF14FGF22RRASCHRM2FGF11PIK3R2MYH10FGF17PIP3FGF7FGF9RAC2INS1PIP5K1CMAPK SignalingpathwayFGFR2C3orf10VCLPIK3R4MYL3RAC1P4ENAHCHRM1PIK3R5DIAP1PIP5K2APIP5K1APIP5KL1NCKAP1VCLBAIAP2FGF5RAF1MOSFGF10RAC3MYLKBDKRB1ITGA1AcetylcholineACTG1PIK3C3NRASMAPK6RDXMAPK3LIMK1GRLF1CHRM4ROCK1PIK3CGROCK2FGF12BradykininARHGEF6GNG12CHRM5INS2FGF13C11orf13Pik3c2bGSNGIT1PIP5K1BMAP2K1RAC1P2ARHGEF4PFN1MAP2K2GNA12SLC9A1ACTG1ARHGEF7ACTBEGFFGFR3FGF2MRASABI2ARPC5ARPC5CSKACTBCFL1FGF16IQGAP1F2VAV1RAC1FGF6PDGFAVIL2PDGFRAPIK3R3Apc2PPP1R12ASSH2FGFR4EGFRSSH1PIP5K2APIK3CDMYL1SOS2PAK4PIP2PIK3CBDIAP3PIK3C2APAK6Focal AdhesionpathwayFGFR1WASF1FGD1PXNCDC42BDKRB2PAK3RRAS2FGF18PIP2ACTN1FGF15/19PAK2PAK7Adherens junctionpathwayWASFGF20SOS1BRAFPDGFRBBCAR1PIP5K2BFGF23PTK2PFN1FGF4PDGFBDOCK1MAPK1PIP5K2CFocal AdhesionpathwayPIK3C2GCD14CFL2CHRM3LPSPIK3CAVIL1KRASFGF1SSH3APCARHGEF1F2RFN1PIK3R1RHOABAIAP2ARHGEF6FGF21FGF8CYFIP2WASF2ACTBGNA13ACTG1MSNFGF3


Description

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Ontology Terms

 

Bibliography

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  1. Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed Europe PMC
  2. Schmitz AA, Govek EE, Böttner B, Van Aelst L; ''Rho GTPases: signaling, migration, and invasion.''; Exp Cell Res, 2000 PubMed Europe PMC
  3. Takai Y, Sasaki T, Matozaki T; ''Small GTP-binding proteins.''; Physiol Rev, 2001 PubMed Europe PMC
  4. Pollard TD; ''The cytoskeleton, cellular motility and the reductionist agenda.''; Nature, 2003 PubMed Europe PMC
  5. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR; ''Cell migration: integrating signals from front to back.''; Science, 2003 PubMed Europe PMC
  6. Sastry SK, Burridge K; ''Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.''; Exp Cell Res, 2000 PubMed Europe PMC
  7. Fukata M, Nakagawa M, Kuroda S, Kaibuchi K; ''Cell adhesion and Rho small GTPases.''; J Cell Sci, 1999 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106499view21:45, 4 September 2019KhanspersModified description
105801view22:50, 15 August 2019KhanspersModified description
94816view02:38, 6 October 2017Khanspersadded literature from KEGG
94815view02:35, 6 October 2017Khanspersconnected interactions
79977view12:56, 29 April 2015Zarichanged LOC442775 to official name and annotated FGF15
79526view10:02, 24 March 2015Zariadded ID for DIAP1 gene
79445view06:57, 22 March 2015EgonwReplaced a gene name with its Entrez Gene identifier.
72124view07:38, 25 October 2013Mkutmonadded datasource for "Focal Adhesion pathway" and "MAPK Signaling pathway"
71376view18:38, 17 October 2013MaintBotAutomated update of data sources
71254view20:57, 16 October 2013MaintBotAutomated update of data sources
68950view17:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
67623view11:34, 26 June 2013DdiglesOntology Term : 'cell adhesion signaling pathway' added !
49262view23:46, 11 July 2012AlexanderPicoReverted to version '12:02, 7 October 2011' by AlexanderPico
49261view22:24, 11 July 2012Diana.gcoPeriodical save, work in progress
45278view19:02, 7 October 2011Khanspersremoved genmapp comments
45276view19:00, 7 October 2011KhanspersOntology Term : 'regulatory pathway' added !
41107view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
38855view18:06, 24 September 2010Khanspers
38768view23:31, 23 September 2010KhanspersAdded pathway links, chnaged interactions
34470view18:32, 10 December 2009MaintBotAutomatic update of empty xrefs
32449view17:21, 15 August 2009MaintBotFixed text labels
32129view13:54, 14 August 2009MaintBotFixed group labels
20783view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Regulation of Actin Cytoskeleton KEGG]] moved to [[Pathway:WP51]]: Moved to stable identifier
14231view03:25, 22 May 2008AlexanderPicoConnected!
14227view03:16, 22 May 2008AlexanderPicoPeriodical save, work in progress
14225view03:06, 22 May 2008AlexanderPicoPeriodical save, work in progress
14223view02:55, 22 May 2008AlexanderPicoPeriodical save, work in progress
14221view02:47, 22 May 2008AlexanderPicoAdditional work with aliases
14219view02:45, 22 May 2008AlexanderPicoPeriodical save, work in progress
14217view02:22, 22 May 2008AlexanderPicoFixed datanodes and aliases
14215view02:13, 22 May 2008AlexanderPicoPeriodical save, work in progress
14213view02:02, 22 May 2008AlexanderPicoFixed small molecules
14211view01:50, 22 May 2008AlexanderPicoFixed labels
14209view01:42, 22 May 2008AlexanderPicoPeriodical save, work in progress
14207view01:13, 22 May 2008AlexanderPicoGrouped complexes and paralogs
13114view11:16, 17 May 2008MaintBotautomated metabolite conversion
12940view10:42, 17 May 2008MaintBotSticky edges patch by Sjoerd
8354view13:46, 7 January 2008MaintBot[[Pathway:Human:Regulation of Actin Cytoskeleton KEGG]] moved to [[Pathway:Homo sapiens:Regulation of Actin Cytoskeleton KEGG]]: Renaming species
7795view16:18, 18 December 2007MaintBotfixed category names
7289view12:41, 4 November 2007MaintBotAdded categories to GPML
6366view22:18, 22 May 2007169.230.77.174gpml file for [[Human:Regulation_of_Actin_Cytoskeleton_KEGG]]

External references

DataNodes

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NameTypeDatabase referenceComment
ABI2GeneProduct10152 (Entrez Gene)
ACTBGeneProduct60 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
ACTN1GeneProduct87 (Entrez Gene)
APCGeneProduct324 (Entrez Gene)
ARHGEF1GeneProduct9138 (Entrez Gene)
ARHGEF4GeneProduct50649 (Entrez Gene)
ARHGEF6GeneProduct9459 (Entrez Gene)
ARHGEF7GeneProduct8874 (Entrez Gene)
ARPC5GeneProduct10092 (Entrez Gene)
AcetylcholineMetabolite51-84-3 (CAS)
Adherens junction pathwayPathway
Apc2GeneProduct10297 (Entrez Gene)
BAIAP2GeneProduct10458 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
BDKRB1GeneProduct623 (Entrez Gene)
BDKRB2GeneProduct624 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
BradykininMetabolite58-82-2 (CAS)
C11orf13GeneProduct8045 (Entrez Gene)
C3orf10GeneProduct55845 (Entrez Gene)
CD14GeneProduct929 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CFL1GeneProduct1072 (Entrez Gene)
CFL2GeneProduct1073 (Entrez Gene)
CHRM1GeneProduct1128 (Entrez Gene)
CHRM2GeneProduct1129 (Entrez Gene)
CHRM3GeneProduct1131 (Entrez Gene)
CHRM4GeneProduct1132 (Entrez Gene)
CHRM5GeneProduct1133 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CSKGeneProduct1445 (Entrez Gene)
CYFIP2GeneProduct26999 (Entrez Gene)
DIAP1GeneProduct1729 (Entrez Gene)
DIAP3GeneProduct81624 (Entrez Gene)
DOCK1GeneProduct1793 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ENAHGeneProduct55740 (Entrez Gene)
F2GeneProduct2147 (Entrez Gene)
F2RGeneProduct2149 (Entrez Gene)
FGD1GeneProduct2245 (Entrez Gene)
FGF10GeneProduct2255 (Entrez Gene)
FGF11GeneProduct2256 (Entrez Gene)
FGF12GeneProduct2257 (Entrez Gene)
FGF1GeneProduct2246 (Entrez Gene)
FGF13GeneProduct2258 (Entrez Gene)
FGF14GeneProduct2259 (Entrez Gene)
FGF15/19GeneProduct9965 (Entrez Gene)
FGF16GeneProduct8823 (Entrez Gene)
FGF17GeneProduct8822 (Entrez Gene)
FGF18GeneProduct8817 (Entrez Gene)
FGF20GeneProduct26281 (Entrez Gene)
FGF21GeneProduct26291 (Entrez Gene)
FGF2GeneProduct2247 (Entrez Gene)
FGF22GeneProduct27006 (Entrez Gene)
FGF23GeneProduct8074 (Entrez Gene)
FGF3GeneProduct2248 (Entrez Gene)
FGF4GeneProduct2249 (Entrez Gene)
FGF5GeneProduct2250 (Entrez Gene)
FGF6GeneProduct2251 (Entrez Gene)
FGF7GeneProduct2252 (Entrez Gene)
FGF8GeneProduct2253 (Entrez Gene)
FGF9GeneProduct2254 (Entrez Gene)
FGFR1GeneProduct2260 (Entrez Gene)
FGFR2GeneProduct2263 (Entrez Gene)
FGFR3GeneProduct2261 (Entrez Gene)
FGFR4GeneProduct2264 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
Focal Adhesion pathwayPathwayWP306 (WikiPathways)
GIT1GeneProduct28964 (Entrez Gene)
GNA12GeneProduct2768 (Entrez Gene)
GNA13GeneProduct10672 (Entrez Gene)
GNG12GeneProduct55970 (Entrez Gene)
GRLF1GeneProduct2909 (Entrez Gene)
GSNGeneProduct2934 (Entrez Gene)
INS1GeneProduct
INS2GeneProduct
IQGAP1GeneProduct8826 (Entrez Gene)
ITGA1GeneProduct3672 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LIMK1GeneProduct3984 (Entrez Gene)
LPSMetaboliteC00338 (KEGG Compound)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK Signaling pathwayPathwayWP382 (WikiPathways)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MOSGeneProduct4342 (Entrez Gene)
MRASGeneProduct22808 (Entrez Gene)
MSNGeneProduct4478 (Entrez Gene)
MYH10GeneProduct4628 (Entrez Gene)
MYL1GeneProduct4632 (Entrez Gene)
MYL3GeneProduct4634 (Entrez Gene)
MYLKGeneProduct4638 (Entrez Gene)
NCKAP1GeneProduct10787 (Entrez Gene)
NRASGeneProduct4893 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
PAK7GeneProduct57144 (Entrez Gene)
PDGFAGeneProduct5154 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRAGeneProduct5156 (Entrez Gene)
PDGFRBGeneProduct5159 (Entrez Gene)
PFN1GeneProduct5216 (Entrez Gene)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PIK3R5GeneProduct23533 (Entrez Gene)
PIP2MetaboliteC04637 (KEGG Compound)
PIP3MetaboliteC05981 (KEGG Compound)